Curriculum Vitae

General Information


Research Career

Awards and Honors

Member of organizing committees:

Referee for Grant Offices

German Research Foundation (DFG) – Germany

The French National Research Agency – France

Medical Research Council – UK

Research into Ageing – UK

Austrian Academy of Science – Austria

National Research Council (NCN)– Poland

National Research Council (CNCS)– Romania

Dutch National Science Foundation(NOW) – The Netherlands

Referee for Scientific Journals

Research Support

Invited Speaker (2008-2013)








1. Peer-reviewedarticles

1. Li L, Trifunovic A,Köhler M, Wang Y, Berglund JP, Illies C, Juntti-Berggren L, Larsson NG, Berggren PO. Defects in ß-Cell Ca2+ Dynamics in Age-Induced Diabetes. Diabetes. 2014 Jul 1. pii: DB_131855. [Epub ahead of print]

2. Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P,Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Kunz WS, Trifunovic A.Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity.PLoS Genet. 2014 Jun 19;10(6):e1004385.

3. Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A,Eming SA, Wiesner RJ, Hacker UT, Kashkar H.Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med. 2014 May 1;6(5):624-39.

4. Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, Trifunovic A.Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart. Cell Metab. 2014 Mar 4;19(3):458-69.

5. Pujol C, Bratic-Hench I, Sumakovic M, Hench J, Mourier A, Baumann L, Pavlenko V, Trifunovic A.Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant.PLoS One. 2013;8(3):e59493. doi: 10.1371/journal.pone.0059493. Epub 2013 Mar 28.

6. Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A,Suomalainen A. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.Cell Metab. 2012 Jan 4;15(1):100-9. doi: 10.1016/j.cmet.2011.11.012.

7. Hench J, Bratic Hench I, Pujol C, Ipsen S, Brodesser S, Mourier A, Tolnay M, Frank S, Trifunovic A.A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans. PLoS One. 2011;6(12):e28417.

8. Kukat A, Edgar D, Bratic I, Maiti P andTrifunovic A. Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts. (2011) BiochemBiophys Res Commun. 2011 Jun 10;409(3):394-9.

9. Ross JM, Öberg J, Brene S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ, Olson L. High brain Lactate is a hallmerkofagingandcausedby a shift in thelactatedehydrogenase A/B ratio. (2010) ProcAcadNatlSci USA Nov 16;107(46):20087-92. Epub 2010 Nov 1.

10. Bratic I, Hench J, Trifunovic A:C. elegans as a modelsystemfor mtDNA replicationdefects. (2010) MethodsAug;51(4):437-43. Epub 2010 Mar 15.

11. Edgar D, Larsson NG, Trifunovic A. Point mutationsarecausingprogeroidphenotypes in mtDNA mutator mice. (2010) CellMetab. Jan 6;11(1):93.

12. Edgar D, Shabalina I, Camara Y, Wredenberg A, Calvaruso MA, Nijtmans L, Nedergaard J, Cannon B, Larsson NG, Trifunovic A. (2009) Random pointmutationswithmajoreffects on proteincoding genes driveprematureageing in mtDNA mutator mice. CellMetab. Aug; (10):131-138.

13. Bratic I, Hench J, Henriksson J, Antebi A, Burglin T, Trifunovic A. (2009) Mitochondrial DNA levels, but not mitochondrial DNA polymerase, are essential for C. elegans development. Nucleic Acids Res. Apr;37(6):1817-28. Epub 2009 Jan 30.

14. Stewart JB, Freyer C, Elson JL, Wredenberg A, Cansu Z, Trifunovic A,Larsson NG (2008) Purifyingselection in transmissionofmammalianmitochondrial DNA.PLoSBiol Jan;6(1):e10.

15. Niu X, Trifunovic A, Larsson NG, Canlon B. (2007) Somatic mtDNA mutationscause progressive hearingloss in themouse. ExpCell Research Nov 1;313 (18):3924-34. Epub 2007 Jun 29

16. EkstrandMI, TerziogluM, GalterD, Zhu S, HofstetterC, Lindqvist E, Trifunovic A, Hoffer B, Mohammed AH, Olson L, Larsson NG. (2007) Respiratorychaindysfunction in dopamineneuronscauseskeyParkinson´sdiseasepathology in mice.ProcNatlAcadSci U S A. 23;104(4):1325-30. Epub 2007 Jan 16.

17. Duvezin-Caubet S, Jagasia R, WagenerJ, Hofmann S, Trifunovic A, Hansson A, Chomyn A, Bauer MF, Attardi G, Larsson NG, Neupert W, Reichert AS. (2006) Roleof OPA1 in distinguishingdysfunctionalfromfunctionalmitochondria.J BiolChemDec 8;281(49):37972-9. Epub 2006 Sep 26.

18. Trifunovic, A., Hansson, A., Wredenberg, A., Rovio, A., Dufour, E., Khvorostov, I., Spelbrink, J., Wibom, R., Jacobs, H., Larsson, N. (2005) Somatic mtDNA mutationscauseageingphenotypeswithoutaffectingreactiveoxygenspeciesproduction.ProcNatlAcadSci USA, 102, 17993-17998

19. Hance N, Ekstrand M, Trifunovic A. (2005) Mitochondrial DNA polymerasegammais essential formammalianembryogenesis. Hum Mol Genet. 14 (13); 1775-1783.

20. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson NG. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. May 27;429 (6990):417-23.

21. Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM. (2002) Mitochondrialtranscriptionfactors B1 and B2 activatetranscriptionof human mtDNA.Nat Genet. Jul; 31 (3):289-94.

22. Trifunovic A, Zaric J, Lusic M, Mijatovic M, Glisin V, Popovic Z. (2001) Induced synthesis of albumin-like protein in damaged rat reticulocytes. Br J Haematol. 115(1):205-15

23. Djurkovic, A,Zaric, J., Lusic, M, Glisin, V. and Popovic, Z. Differences in rat RBC cytosol induced after in vivo phenylhydrazine treatment.Cell Biol. Int. 23 (10): 677-683 (1999).

24. Lusic, M., Zaric, J., Djurkovic, A., Glisin, V. and Popovic, Z. The Lack of Protein 4,1a in Red Blood Cells of the Hereditarily Anemic Belgrade Laboratory (b/b) rat. J. Cell. Biochem.,75: 56-63 (1999)

25. Zaric, J., Lusic, M., Djurkovic, A., Glisin, V., Popovic, Z., Hsp70 protein is membrane bound in red blood cells of human hereditary haemolytic anemias.Comp. Hematol. Int., 8: 205-209, (1999).

2. Review articles, bookchapters etc.

1. Trifunovic A, Ventura N. Mitochondria and metabolic control of the aging process. ExpGerontol. 2014 Aug;56:1-2.

2. Dogan AS & Trifunovic A.Modeling themitochondrialdysfunction in mice.Physiol Res. 2011;60 Suppl 1:S61-70.

3. Brüning J, Langer T, Trifunovic A. Highlight: The biologyofaging: mechanismsandinterventions. (2010) Biol Chem. Oct;391(10):1113.

4. Bratic I, Trifunovic A:Mitochondrialenergymetabolismandageing.(2010) BBA –BioenergeticsMay-June Jan 11. [Epubaheadofprint]

5. Bratic I, Hench J, Trifunovic A. C. elegans as a modelsystemfor mtDNA replicationdefects. Methods (2010)

6. Kukat A, Pujol C, Bratic I, Trifunovic A.Accumulationofmitochondrial DNA mutationsduringmammalianageing. (2010) In:“BioenergeticsandBiomembranes” Volume: “Longevity, Mitochondriaand Oxygen Free Radicals”. (Eds.) Barja G, Pamplona R. Research Signpost

7. Kukat A, Trifunovic A.Somatic mtDNA mutationsandaging - Facts andfancies (2009). ExpGerontol. Jan-Feb;44(1-2):101-5.

8. Trifunovic A, Larsson NG. Mitochondrialdysfunction in mammalianageing. (2008) J IntMedFeb;263(2):167-78.

9. Edgar D, Trifunovic A. Mitochondria: The Dark Side. (2007) In: RoleofPhysicalExercise in PreventingDiseaseandImprovingthe Quality of Life. (Eds.) VStocchi, P De Feo, DA. Hood. Springer ISBN: 978-88-470-0375-0

10. Trifunovic A. Mitochondrial DNA andAgeing.BBA –Bioenergetics1757 (5-6): 611-617 May-June (2006)

11. Wredenberg A and Trifunovic A.Modelling the mitochondrial role in ageing.(2005) Drug Discovery Today: Disease Models2 (4): 257-263

12. Trifunovic A, Larsson NG. Tissue-specific knockout model for study of mitochondrial DNA mutation disorders. (2002) Methods Enzymol 353: 409-21

3. Peer-reviewedconferencecontributions.

1. Edgar D, Bratic I and Trifunovic A. Mechanism of aging in mtDNA mutator mice.Fourth European Bioenergetic Conference, July 23-27, 2006 BBA -Bioenergetics1757: Suppl. 1 (2006)

2. Trifunovic A, Larsson NG, Wredenberg A. Creationof mtDNA mutator mice 6th European Meeting on MitochondrialPathology, July 01-04, 2004 BBA -Bioenergetics1657: 21-21, Suppl. 1 (2004)

4. Patents.

Patent: mtDNA mutator mice (2004-2006)

Inventors: Aleksandra Trifunovic, Maria Falkenberg-Gustafsson and Nils-Göran Larsson

5. Popular-scientificarticles/presentations.

1. Trifunovic A. Le mythe des radicauxlibres. La Recherche (2007)406: 35-39