List of Publications
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1. Somatic mtDNA mutations cause progressive hearing loss in the mouse.
Niu X, Trifunovic A, Larsson NG, Canlon B.
Exp Cell Res. 2007 Nov 1;313(18):3924-34. Epub 2007 Jun 29.
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2. Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity.
Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Kunz WS, Trifunovic A.
PLoS Genet. 2014 Jun 19;10(6):e1004385. doi: 10.1371/journal.pgen.1004385. eCollection 2014 Jun.
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3. Mitochondria and metabolic control of the aging process.
Trifunovic A, Ventura N.
Exp Gerontol. 2014 Aug;56:1-2. doi: 10.1016/j.exger.2014.05.009. No abstract available.
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4. Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.
Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H.
EMBO Mol Med. 2014 May 1;6(5):624-39. doi: 10.1002/emmm.201303016
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5. Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart.
Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, Trifunovic A.
Cell Metab. 2014 Mar 4;19(3):458-69. doi: 10.1016/j.cmet.2014.02.004.
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6. Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant.
Pujol C, Bratic-Hench I, Sumakovic M, Hench J, Mourier A, Baumann L, Pavlenko V, Trifunovic A.
PLoS One. 2013;8(3):e59493. doi: 10.1371/journal.pone.0059493. Epub 2013 Mar 28.
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7. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.
Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A.
Cell Metab. 2012 Jan 4;15(1):100-9. doi: 10.1016/j.cmet.2011.11.012.
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8. A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans.
Hench J, Bratic Hench I, Pujol C, Ipsen S, Brodesser S, Mourier A, Tolnay M, Frank S, Trifunovic A.
PLoS One. 2011;6(12):e28417. doi: 10.1371/journal.pone.0028417. Epub 2011 Dec 5.
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9. Random mtDNA mutations modulate proliferation capacity in mouse embryonic fibroblasts.
Kukat A, Edgar D, Bratic I, Maiti P, Trifunovic A.
Biochem Biophys Res Commun. 2011 Jun 10;409(3):394-9. doi: 10.1016/j.bbrc.2011.04.145. Epub 2011 May 7.
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10. High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.
Ross JM, Öberg J, Brené S, Coppotelli G, Terzioglu M, Pernold K, Goiny M, Sitnikov R, Kehr J, Trifunovic A, Larsson NG, Hoffer BJ, Olson L.
Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20087-92. doi: 10.1073/pnas.1008189107. Epub 2010 Nov 1.
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11. Highlight: The biology of aging: mechanisms and intervention.
Brüning J, Langer T, Trifunovic A.
Biol Chem. 2010 Oct;391(10):1113. doi: 10.1515/BC.2010.127. No abstract available.
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12. Caenorhabditis elegans as a model system for mtDNA replication defects.
Bratic I, Hench J, Trifunovic A.
Methods. 2010 Aug;51(4):437-43. doi: 10.1016/j.ymeth.2010.03.003. Epub 2010 Mar 15.
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13. The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging.
Edgar D, Trifunovic A.
Aging (Albany NY). 2009 Dec 11;1(12):1028-32.
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14. Response: Point Mutations Are Causing Progeroid Phenotypes in the mtDNA Mutator Mouse.
Edgar D, Larsson NG, Trifunovic A.
Cell Metab. 2010 Jan 6;11(1):93. No abstract available.
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15. Mitochondrial energy metabolism and ageing.
Bratic I, Trifunovic A.
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):961-7. doi: 10.1016/j.bbabio.2010.01.004. Epub 2010 Jan 11. Review
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16. Point mutations are causing progeroid phenotypes in the mtDNA mutator mouse.
Edgar D, Larsson NG, Trifunovic A.
Cell Metab. 2010 Jan;11(1):1. doi: 10.1016/j.cmet.2009.12.001. No abstract available.
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17. Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
Edgar D, Shabalina I, Camara Y, Wredenberg A, Calvaruso MA, Nijtmans L, Nedergaard J, Cannon B, Larsson NG, Trifunovic A.
Cell Metab. 2009 Aug;10(2):131-8. doi: 10.1016/j.cmet.2009.06.010.
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18. Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development.
Bratic I, Hench J, Henriksson J, Antebi A, Bürglin TR, Trifunovic A.
Nucleic Acids Res. 2009 Apr;37(6):1817-28. doi: 10.1093/nar/gkp018. Epub 2009 Jan 30.
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19. Somatic mtDNA mutations and aging--facts and fancies.
Kukat A, Trifunovic A.
Exp Gerontol. 2009 Jan-Feb;44(1-2):101-5. doi: 10.1016/j.exger.2008.05.006. Epub 2008 May 21. Review.
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20. Strong purifying selection in transmission of mammalian mitochondrial DNA.
Stewart JB, Freyer C, Elson JL, Wredenberg A, Cansu Z, Trifunovic A, Larsson NG.
PLoS Biol. 2008 Jan;6(1):e10. doi: 10.1371/journal.pbio.0060010.
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21. Somatic mtDNA mutations cause progressive hearing loss in the mouse.
Niu X, Trifunovic A, Larsson NG, Canlon B.
Exp Cell Res. 2007 Nov 1;313(18):3924-34. Epub 2007 Jun 29.
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22. Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons.
Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS, Trifunovic A, Hoffer B, Cullheim S, Mohammed AH, Olson L, Larsson NG.
Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30. Epub 2007 Jan 16.
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23. Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.
Duvezin-Caubet S, Jagasia R, Wagener J, Hofmann S, Trifunovic A, Hansson A, Chomyn A, Bauer MF, Attardi G, Larsson NG, Neupert W, Reichert AS.
J Biol Chem. 2006 Dec 8;281(49):37972-9. Epub 2006 Sep 26.
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24. Mitochondrial DNA and ageing.
Trifunovic A.
Biochim Biophys Acta. 2006 May-Jun;1757(5-6):611-7. Epub 2006 Mar 31. Review.
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25. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.
Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, Spelbrink JN, Wibom R, Jacobs HT, Larsson NG.
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17993-8. Epub 2005 Dec 6.
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26. Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis.
Hance N, Ekstrand MI, Trifunovic A.
Hum Mol Genet. 2005 Jul 1;14(13):1775-83. Epub 2005 May 11.
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27. Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG.
Nature. 2004 May 27;429(6990):417-23.
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28. Tissue-specific knockout model for study of mitochondrial DNA mutation disorders.
Trifunovic A, Larsson NG.
Methods Enzymol. 2002;353:409-21. No abstract available.
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29. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.
Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM.
Nat Genet. 2002 Jul;31(3):289-94. Epub 2002 Jun 17.
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30. Lack of protein 4.1a in red blood cells of the hereditarily anemic belgrade laboratory (b/b) rat.
Lusic M, Zaric J, Durkovic A, Glisin V, Popovic Z.
J Cell Biochem. 1999 Oct 1;75(1):56-63.
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31. Differences in rat rbc cytosol induced after in vivo phenylhydrazine treatment.
Djurkovic A, Zaric J, Lusic M, Glisin V, Popovic Z.
Cell Biol Int. 1999;23(10):677-83.