Activation of Receptor Tyrosine Kinases: How is the enzyme activated by dimerization? Does dimerization affect binding of substrates (ATP and peptide)?
Special field: Construction, expression and purification of kinases.
"Dimerization-induced activation of soluble insulin/IGF-1 receptor kinases: An alternative mechanism of activation."
Baer, K., Al-Hasani, H., Parvaresch, S., Corona, T., Rufer, A., Noelle, V., Bergschneider, E., and Klein, H.W. (2001) Biochemistry40, 14268-14278 Medline