Special interests:

• Purification of human placenta insulin receptor, baculovirus expressed insulin receptor kinase and GST-tagged kinases
• Cloning, expression and purification of recombinant proteins

• Mechanism of kinase activation
• Studies of dual kinase activity

• Dimerization-induced activation of soluble insulin/IGF-1 receptor kinases: An alternative mechanism of activation.
  Baer, K., Al-Hasani, H., Parvaresch, S., Corona, T., Rufer, A., Noelle, V., Bergschneider, E., and Klein, H.W. (2001)
  Biochemistry 40, 14268-14278 Medline
• Identification of Ser ¹²⁷⁵ and Ser ¹³⁰⁹ as Autophosphorylation Sites of the Human Insulin Receptor in Intact Cells.
  Tennagels, N., Telting D, Parvaresch, S. Maassen, J.A., and Klein, H.W.
  Biochemical and Biophysical Research Communications 282, 387-393 (2001)
• Recombinant peptide substrates of the insulin receptor.
  Noelle, V., Klein, E., Leven, O., Müller, J., Parvaresch, S., and Klein, H.W. (1996)
  Biol. Chem. Hoppe-Seyler 377, S154
• The dual kinase activity of the insulin receptor in respect to auto- and substrate phosphorylation.
  Tennagels, N., Magg, C., Noelle, V., Parvaresch, S., Müller-Wieland, D., and Klein, H.W. (1997)
  Diabetes 46, suppl. 1, 384