3D-reconstruction of Neurospora crassa mitochondria [Perkins et al., J. Struc. Biol. 119, 260-272 (1997)]
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Welcome to the Langer Lab!
Institute for Genetics
University of Cologne

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Mitochondrial Proteases in Cellular Regulation and Disease

Mitochondria are dynamic cell organelles with essential catabolic and anabolic functions and critical roles in cell death pathways. Mitochondrial dysfunction contributes to ageing and acts causally in the pathogenesis of many neurodegenerative disorders. The group analyses the conserved proteolytic system of these organelles which ensures the quality control of mitochondrial proteins and regulates key steps during mitochondrial biogenesis. Processes associated with mitochondrial membranes are in focus of research. Using Saccharomyces cerevisiae and transgenic and conditional knockout mice as model systems, we analyse the function of conserved mitochondrial proteases on the molecular level as well as their physiological roles and their pathogenic relevance in mammals.

Main areas of research are: