Institute of Genetics - University of Cologne
Section of Molecular Genetics

Transcription factors:

Protein-DNA and Protein-Protein Interactions

Section Head: Benno Müller-Hill


Research and three recent publications

Before my retirement in February 1998 we had analysed the function of seven transcription factors: LacR, GalR, TrpR, AraC and Lambda R of E.coli and GCN4 of yeast. After my retirement we concentrated on LacR and Lambda R. These proteins have like many other proteins modular structure. Thus, their DNA binding domains are well separated from their aggregation domains. Dimers react with DNA targets of dyadic symmetry. It was our goal to understand as well as possible the functions and interactions of these six proteins with their modular partners.   >From our publications of this time period I choose the following three as the most interesting ones:

Collaborations with other institutes

Jeffrey Miller, University of California, Los Angeles, CA, USA
Bernard Révet, Institut Gustave Rousse, Villesuif, France
Wolfram Neiss, Anatomy, University of Cologne, Germany

Financial Support

We gratefully acknowledge financial support by the following agencies or sponsors: Deutsche Forschungsgemeinschaft through SFB 274 ; through Normalverfahren Mu 575/10-12. The general support of Fonds der Chemie and the ground support of the Land Nordrhein-Westfalen are gratefully acknowledged.