14. - E. N.
Grigoryan*, H. J. Anton**, and V. 1.
effects on neural retina regeneration
in the newt
of Developmental Biology Russian
Moscow, Russia; ** Zoologisches Institut, Universität zu
D-50996 Germany )
From experiments on limb and eye lens regeneration in urodeles under
conditions (SFC) it is evident that SFC rather stimulates regeneration
than inhibits it. To investigate comprehensively neural regeneration
SFC, an original model experiment is proposed. The initial results
here concern neural retina regeneration in newts (Pleurodeles waltl)
to microgravity simulated in a radial clinostat. After clinorotation
seven days (until post-operation-day 16), a positive effect on
restoration of detached neural retina was confirmed by different
In detail, an increased number of Müllerian glial cells, an
relative volume of the plexiform layers, reduced cell death, advanced
of retinal pigment epithelium, and extended areas of neural retina
were detected in the rotated newts. Moreover, cell proliferation in the
inner nuclear layer of the neural retina increased as compared with
Thus, simulated low gravity appears to intensify natural cytological
molecular mechanisms of neural retina regeneration in lower vertebrates
(E. N. Grigoryan, H. J. Anton, and V. 1. Mitashov, 1998, Adv. Space
Vol. 22, 293-301).