18. - H. J. Anton, E. Voit (November 1998)     (Back)
Simulation of frequency distributions of slices of different spherical nuclei.
High difficulties exist to determine a tissue in respect of the real distribution of the cell composition by the nuclear size. Problems also exist within those group s of scientists in respect of the frequency distribution of the size of nuclear sections. An other problem was and is it, to determine mathematically the section frequency distribution of a number of sphere, different in size. From literature, it is well known as the so called 'tomatoes salad problem'*.
A relative simple computer program is able to produce a frequency distribution of any sphere mixtures: It has to cut statistically the spheres into slices of defined thickness (e.g. 1) and to collect and distribute the slices in a histogram: e.g. G1-nuclei (vol. = 1000, t = 48 hr.) 2400, G2-nuclei (vol. =2000, t = 3 hr.) 150, S-nuclei (vol. linearly increasing from 1000 to 2000, t = 6 hr.) 300. Measuring the nuclear sections of a certain tissue (diameter or area) delivers data which, processed in a histogram can be interpreted by comparison with a corresponding simulation.
* Lit: G. Bach 1959, 1964, 1965; Elias 1954; Glaser 1968; for reference see: Anton, H.J. und Voit E. Microscopica Acta 84 1981, 17-23 (publ. list. 79)
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