3. Molekulare Medizin:
Analyse von Erbkrankheiten am Beispiel der cystischen Fibrose

Gruppe 01
RJ Riordan et al.
Science 1989, 245 (4922):1066-73
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
   1  Length: 1479  September 2, 2005 09:24  Type: P  Check: 8949  ..

       1  MQRSPLEKAS VVSKLFFSWT RPILRKGYRQ RLELSDIYQI PSVDSADNLS 
      51  EKLEREWDRE LASKKNPKLI NALRRCFFWR FMFYGIFLYL GEVTKAVQPL 
     101  LLGRIIASYD PDNKEERSIA IYLGIGLCLL FIVRTLLLHP AIFGLHHIGM 
     151  QMRIAMFSLI YKKTLKLSSR VLDKISIGQL VSLLSNNLNK FDEGLALAHF 
     201  VWIAPLQVAL LMGLIWELLQ ASAFCGLGFL IVLALFQAGL GRMMMKYRDQ 
     251  RAGKISERLV ITSEMIENIQ SVKAYCWEEA MEKMIENLRQ TELKLTRKAA 
     301  YVRYFNSSAF FFSGFFVVFL SVLPYALIKG IILRKIFTTI SFCIVLRMAV 
     351  TRQFPWAVQT WYDSLGAINK IQDFLQKQEY KTLEYNLTTT EVVMENVTAF 
     401  WEEGFGELFE KAKQNNNNRK TSNGDDSLFF SNFSLLGTPV LKDINFKIER 
     451  GQLLAVAGST GAGKTSLLMM IMGELEPSEG KIKHSGRISF CSQFSWIMPG 
     501  TIKENIIGVS YDEYRYRSVI KACQLEEDIS KFAEKDNIVL GEGGITLSGG 
     551  QRARISLARA VYKDADLYLL DSPFGYLDVL TEKEIFESCV CKLMANKTRI 
     601  LVTSKMEHLK KADKILILNE GSSYFYGTFS ELQNLQPDFS SKLMGCDSFD 
     651  QFSAERRNSI LTETLHRFSL EGDAPVSWTE TKKQSFKQTG EFGEKRKNSI 
     701  LNPINSIRKF SIVQKTPLQM NGIEEDSDEP LERRLSLVPD SEQGEAILPR 
     751  ISVISTGPTL QARRRQSVLN LMTHSVNQGQ NIHRKTTAST RKVSLAPQAN 
     801  LTELDIYSRR LSQETGLEIS EEINEEDLKE CLFDDMESIP AVTTWNTYLR 
     851  YITVHKSLIF VLIWCLVIFL AEVAASLVVL WLLGNTPLQD KGNSTHSRNN 
     901  SYAVIITSTS SYYVFYIYVG VADTLLAMGF FRGLPLVHTL ITVSKILHHK 
     951  MLHSVLQAPM STLNTLKAGG ILNRFSKDIA ILDDLLPLTI FDFIQLLLIV 
    1001  IGAIAVVAVL QPYIFVATVP VIVAFIMLRA YFLQTSQQLK QLESEGRSPI 
    1051  FTHLVTSLKG LWTLRAFGRQ PYFETLFHKA LNLHTANWFL YLSTLRWFQM 
    1101  RIEMIFVIFF IAVTFISILT TGEGEGRVGI ILTLAMNIMS TLQWAVNSSI 
    1151  DVDSLMRSVS RVFKFIDMPT EGKPTKSTKP YKNGQLSKVM IIENSHVKKD 
    1201  DIWPSGGQMT VKDLTAKYTE GGNAILENIS FSISPGQRVG LLGRTGSGKS 
    1251  TLLSAFLRLL NTEGEIQIDG VSWDSITLQQ WRKAFGVIPQ KVFIFSGTFR 
    1301  KNLDPYEQWS DQEIWKVADE VGLRSVIEQF PGKLDFVLVD GGCVLSHGHK 
    1351  QLMCLARSVL SKAKILLLDE PSAHLDPVTY QIIRRTLKQA FADCTVILCE 
    1401  HRIEAMLECQ QFLVIEENKV RQYDSIQKLL NERSLFRQAI SPSDRVKLFP 
    1451  HRNSSKCKSK PQIAALKEET EEEVQDTRL


22 Oktober 2008