Publications

2013

Ziemann A, Hess S, Bhuwania R, Linder S, Kloppenburg P, Noegel AA, Clemen CS.
CRN2 enhances the invasiveness of glioblastoma cells.
Neuro Oncol. 15, 548-61 (2013)

Dadheech PK, Glöckner G, Casper P, Kotut K, Mazzoni CJ, Mbedi S, Krienitz L.
Cyanobacterial diversity in the hot spring, pelagic and benthic habitats of a tropical soda lake.
FEMS microbiology ecology (2013)

Felder M, Romualdi A, Petzold A, Platzer M, Sühnel J, Glöckner G.
GenColors-based comparative genome databases for small eukaryotic genomes.
Nucleic Acids Research 41, D692-D699 (2013)

Schmith A, Groth M, Ratka J, Gatz S, Spaller T, Siol O, Glöckner G, Winckler T.
Conserved gene regulatory function of the carboxy-terminal domain of dictyostelid C-module-binding factor.
Eukaryot Cell 12, 460-468 (2013)

Peche VS, Holak TA, Burgute BD, Kosmas K, Kale SPF, Wunderlich T, Elhamine F, Stehle R, Pfitzer G, Nohroudi K, Addicks K, Stöckigt F, Schrickel JW, Gallinger J, Schleicher M, Noegel AA. (2012).
Ablation of Cyclase Associated Protein 2 (CAP2) leads to cardiomyopathy.
Cell Mol. Life Sci. 70, 527-43 (2013)

Glöckner, G. and Noegel AA.
Comparative genomics in the Amoebozoa clade.
Biological Reviews 88, 215-225 (2013)

Müller-Taubenberger A, Kortholt A and Eichinger L.
Simple System - Substantial Share: The use of Dictyostelium in cell biology and molecular medicine.
Eur. J. Cell Biol. 92, 45-53 (2013)

Bozzaro S, Peracino B and Eichinger L.
Dictyostelium host response to Legionella infection: strategies and assays.
Methods Mol. Biol. 954, 417-438 (2013)

2012

Mahmood Baig S, Sabih D, Rahim MK, Azhar A, Tariq M, Sajid Hussain M, Saqlan Naqvi SM, Raja GK, Khan TN, Jameel M, Iram Z, Noor S, Baig UR, Qureshi JA, Baig SA, Bakhtiar SM.
β-Thalassemia in Pakistan: a pilot program on prenatal diagnosis in Multan.
J Pediatr Hematol Oncol. 34, 90-2 (2012)

Sprinkart AM, Block W, Träber F, Meyer R, Paulin D, Clemen CS, Schröder R, Gieseke J, Schild H, Thomas D.
Characterization of the failing murine heart in a desmin knock-out model using a clinical 3 T MRI scanner.
Int J Cardiovasc Imaging 28:1699-1705 (2012)

Lu W, Schneider M, Neumann S, Jaeger V-M, Taranum S, Munck M, Cartwright S, Richardson C, Carthew J, Noh K, Goldberg M, Noegel AA, Karakesisoglou I.
Nesprin interchain associations control nuclear size.
Cell Mol Life Sci. 69, 3493-509 (2012)

Clemen CS, Eichinger L and Schröder R.
Reply: Hereditary spastic paraplegia caused by a mutation in the VCP gene - VCP: A jack of all trades in neuro- and myodegeneration?
Brain 135, 1-3 (2012)

Arhzaouy K, Strucksberg KH, Tung SM, Tangavelou K, Stumpf M, Faix J, Schröder R, Clemen CS, and Eichinger L.
Heteromeric p97/p97R155C complexes induce dominant negative changes in wild-type and autophagy 9-deficient Dictyostelium strains.
PLoS ONE 7, e46879 (2012)

Hussain MS , Muhammad F, Bakhtiar SM, Inayat IA, Janzen E, Toliat MR, Eiberg H, Kjaer KW, Tommerup N, Noegel AA, Nürnberg P, Baig SM, Hansen L.
Genetic heterogeneity in Pakistani microcephaly families.
Clinical Genetics 9999 (999A) (2012)

Klionsky, DJ. and 1269 others.
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 8:4, 1-100 (2012)

Hussain MS, Baig SM, Neumann S, Nürnberg G, Farooq M, Ahmad I, Wajid M, Alef T, Hennies H-C, Technau M, Altmüller J, Frommolt P, Thiele H, Noegel AA, Nürnberg P.
A Truncating Mutation of CEP135 is associated with primary microcephaly and disturbed centrosomal function.
Am. J. Hum. Genet. 90, 871-8 (2012)

Chang GS, Noegel AA, Mavrich TN, Müller R, Tomsho L, Ward E, Felder M, Jiang C, Eichinger L, Glöckner G, Schuster S, Pugh BF.
Combinatorial use of poly-A/T tracts in organizing genes, nucleosomes and the transcription machinery in Dictyostelium.
Genome Research 22, 1098-106 (2012)

Taranum S, Vaylann E, Meinke P, Abraham S, Yang L, Neumann S, Karakesisoglou I, Wehnert M, Noegel AA.
LINC complex alterations in DMD and EDMD/CMT fibroblasts.
European Journal of Cell Biology 91, 614-28 (2012)

Sultana H, Neelakanta G, Rivero F, Blau-Wasser R, Schleicher M, Noegel AA.
Ectopic expression of Cyclase associated protein CAP restores the streaming and aggregation defects of Adenylyl Cyclase a deficient Dictyostelium discoideum cells.
BMC Dev. Biol. 12:3 (2012)

Rashmi RN, Eckes B, Glöckner G, Groth M, Neumann S A, Gloy J, Sellin L, Walz G, Schneider M, Karakesisoglou I, Ludwig E, Noegel AA.
The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing.
Nucleus 3, 172-86 (2012)

Taranum S, Sur, I, Müller R, Lu W, Rashmi RN, Munck M, Neumann S, Karakesisoglou I, Noegel AA.
Cytoskeletal interactions at the nuclear envelope mediated by Nesprins.
Int. J. Cell Biol. 736524 (2012)

Xavier CP, Rastetter RH, Blömacher M, Stumpf M, Himmel M, Morgan RO, Fernandez MP, Wang C, Osman A, Miyata Y, Gjerset RA, Eichinger L, Hofmann A, Linder S, Noegel AA, Clemen CS.
Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration.
Sci Rep. 2:241 (2012)

2011

Kalbe E, Onur OA, Minnerop M, Reimann J, Althaus A, Ahmadzadehfar H, Dodel R, Strach K, Clemen CS, Herholz K, Haense C, Fink GR, Schröder R. Early signs of VCP-related frontotemporal dementia: a neuropsychological, FDG-PET and fMRI study.
J. Neurol. 258, 515-518 (2011)

Miller SE, Sahlender DA, Graham SC, Höning S, Robinson MS, Peden AA, Owen DJ.
The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.
Cell. 147, 1118-31 (2011)

Eichinger L.
Model organisms to study host - pathogen interaction: prerequisites for the identification of novel drug targets.
Curr. Drug Targets 12, 934-935 (2011)

Bozzaro, S. and L. Eichinger.
The professional phagocyte Dictyostelium discoideum as a model host for bacterial pathogens.
Curr. Drug Targets 12, 942-954 (2011)

Sucgang R, Kuo A, Tian X, Salerno W, Parikh A, Feasley CL, Dalin E, Tu H , Huang E, Barry K, Lindquist E, Shapiro H, Bruce D, Schmutz J, Salamov A, Fey P, Gaudet P, Anjard C, Babu MM, Basu S, Bushmanova Y, van der Wel H, Katoh-Kurasawa M, Dinh C, Coutinho PM, Saito T, Elias M, Schaap P, Kay RR, Henrissat B, Eichinger L, Rivero F, Putnam NH, West CM, Loomis WF, Chisholm RL, Shaulsky G, Strassmann JE, Queller DC, Kuspa A, Grigoriev IV.
Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum.
Genome Biol. 12, R20 (2011)

Sillo A., Matthias J, Konertz R, Bozzaro S, Eichinger L.
Salmonella thyphimurium is pathogenic for Dictyostelium cells and subverts the starvation response.
Cell. Microbiol.13, 1793–1811 (2011)

Riyahi TY, Frese F, Steinert M, Omosigho N N, Glöckner G, Eichinger L, Orabi B, Williams RSB, Noegel AA.
RpkA, a highly conserved GPCR with a lipid kinase domain, has a role in phagocytosis and anti-bacterial defense.
PLoS One 6, e27311. (2011)

Noegel AA, Neumann S.
The role of nesprins as multifunctional organizers in the nucleus and the cytoskeleton.
Biochem Soc Trans. 39, 1725-8 (2011)

Sitar T, Gallinger J, Ducka A, Ikonen T, Wohlhoefler M, Schmoller K, Bausch A, Joel P, Trybus K, Noegel A, Schleicher M, Huber R, Holak T.
Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly
Proc. Natl. Acad. Sci. 108, 19575-80 (2011)

Heidel A, Lawal H, Felder M, Schilde C, Helps N, Tunggal B, Rivero F, John U, Schleicher M, Eichinger L, Platzer M, Noegel A, Schaap P, Glöckner G.
Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication
Genome Res. 21, 1882-91 (2011)

Schneider M, Lu W, Neumann S, Brachner A, Gotzmann J, Noegel AA, Karakesisoglou I.
Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope
Cell Mol Life Sci. 68, 593-610 (2011)

Shina MC, Müller-Taubenberger A, Unal C, Schleicher M, Steinert M, Eichinger L, Müller R, Blau-Wasser R, Glöckner G, Noegel AA.
Redundant and unique roles of coronin proteins in Dictyostelium
Cell Mol. Life Sci. 68, 303-13 (2011)

2010

Clemen CS, Tangavelou K, Strucksberg K-H, Just S, Gaertner L, Regus-Leidig H, Stumpf M, Reimann J, Coras R, Morgan RO, Fernandez M-PO, Hofmann A, Müller S, Schoser B, Hanisch F-G, Rottbauer R, Blümcke I, von Hörsten S, Eichinger L, and Schröder R.
Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases
Brain 133, 2920-2941 (2010)

Schrickel JW, Stöckigt F, Krzyzak W, Paulin D, Li Z, Lübkemeier I, Fleischmann B, Sasse P, Linhart M, Lewalter T, Nickenig G, Lickfett L, Schröder R, Clemen CS.
Cardiac conduction disturbances and differential effects on atrial and ventricular electrophysiological properties in desmin deficient mice
J Interv Card Electrophysiol. 28, 71-80 (2010)

Strucksberg K-H, Tangavelou K, Schröder R, Clemen CS.
Proteasomal activity in skeletal muscle: a matter of assay design, muscle type, and age
Anal Biochem. 399, 225-9 (2010)

Mondal S, Burgute B, Rieger D, Müller R, Rivero F, Faix J, Schleicher M, Noegel AA.
Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with filamin and cortexillin I
PLoS One. 5, e15440 (2010)

Neumann S, Schneider M, Daugherty RL, Gottardi CJ, Eming SA, Beijer A, Noegel AA, Karakesisoglou I.
Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope
J Biol Chem. 285, 34932-8 (2010)

Lang E, Lang PA, Shumilina E, Qadri SM, Kucherenko Y, Kempe DS, Föller M, Capasso A, Wieder T, Gulbins E, Clemen CS, Herr C, Noegel AA, Huber SM, Lang F.
Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7
Pflugers Arch. 460, 667-76 (2010)

Shcherbakova O, Serebryanaya D, Postnikov A, Schroeter MM, Zittrich S, Noegel AA, Shirinsky V, Vorotnikov A, Pfitzer G.
Kinase related protein / telokin inhibits Ca²⁺-independent contraction in triton skinned guinea pig taenia coli.
Biochem J. 429, 291-302 (2010)

Ducka AM, Joel P, Popowicz GM, Trybus KM, Schleicher M, Noegel AA, Huber R, Holak TA, Sitar T.
Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation
Proc Natl Acad Sci. 107, 11757-62 (2010)

Shina MC, Müller R, Blau-Wasser R, Glöckner G, Schleicher M, Eichinger L, Noegel AA, Kolanus W.
A cytohesin homolog in Dictyostelium amoebae.
PLoS One 23, e9378 (2010)

Tung SM, Unal C, Ley A, Peña C, Tunggal B, Noegel AA, Krut O, Steinert M, Eichinger L.
Loss of Dictyostelium ATG9 results in a pleiotropic phenotype affecting growth, development, phagocytosis and clearance and replication of Legionella pneumophila
Cell Microbiol. 12, 765-80 (2010)

Shina MC, Uenal C, Eichinger L, Mueller-Taubenberger A, Schleicher M, Steinert M, Noegel AA.
A coronin7 homolog with functions in actin-driven processes.
J Biol Chem. 19, 9249-61 (2010)

2009

Palka-Santini, M., B.E.E. Cleven, L. Eichinger, M. Krönke and O. Krut.
Large Scale Multiplex (LSplex) PCR Improves Pathogen Detection by DNA Microarrays
BMC Microbiology 9, 1-14 (2009)

Lang PA, Kasinathan RS, Brand VB, Duranton C, Lang C, Koka S, Shumilina E, Kempe DS, Tanneur V, Akel A, Lang KS, Foller M, Kun JF, Kremsner PG, Wesselborg S, Laufer S, Clemen CS, Herr C, Noegel AA, Wieder T, Gulbins E, Lang F, Huber SM.
Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency.
Cell Physiol Biochem. 24, 415-28 (2009)

Blau-Wasser R, Euteneuer U, Xiong H, Gassen B, Schleicher M, Noegel AA.
CP250, a novel acidic coiled-coil protein of the Dictyostelium centrosome, affects growth, chemotaxis, and the nuclear envelope.
Mol Biol Cell. 20, 4348-61 (2009)

Xavier CP, Rastetter RH, Stumpf M, Rosentreter A, Müller R, Reimann J, Cornfine S, Linder S, van Vliet V, Hofmann A, Morgan RO, Fernandez MP, Schröder R, Noegel AA, Clemen CS
Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle
J Mol Biol. 393, 287-99 (2009)

Dawe HR, Adams M, Wheway G, Szymanska K, Logan CV, Noegel AA, Gull K, Johnson CA.
Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.
J Cell Sci. 122, 2716-2726 (2009)

Olins AL, Hoang TV, Zwerger M, Herrmann H, Zentgraf H, Noegel AA, Karakesisoglou I, Hodzic D, Olins DE.
The LINC-less granulocyte nucleus.
Eur J Cell Biol. 88, 203-14 (2009)

Sultana H, Neelakanta G, Eichinger L, Rivero F, Noegel AA.
Microarray phenotyping places cyclase associated protein CAP at the crossroad of signaling pathways reorganizing the actin cytoskeleton in Dictyostelium.
Exp Cell Res. 315, 127-40 (2009)

Clemen CS, Fischer D, Reimann J, Eichinger L, Müller CR, Müller HD, Goebel HH, and Schröder R
How much mutant protein is needed to cause a protein aggregate myopathy in vivo? - Lessons from an exceptional desminopathy
Human Mutation 30, E490-E499 (2009)

2008

Roadcap DW, Clemen CS, Bear JE.
The role of mammalian coronins in development and disease.
Subcell Biochem. 48, 124-35 (2008)

Xavier CP, Eichinger L, Fernandez MP, Morgan RO, Clemen CS.
Evolutionary and functional diversity of coronin proteins.
Subcell Biochem. 48, 98-109 (2008)

Schneider M, Noegel AA, Karakesisoglou I.
KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope.
Biochem Soc Trans. 36, 1368-72 (2008)

Clemen CS, Rybakin V, Eichinger L.
The coronin family of proteins.
Subcell Biochem. 48, 1-5 (2008)

Eichinger, L., L. Moll and M. Armbrecht
Use of CyTM labeled cDNA in microarray analyses after determination of the incorporation rate with the Eppendorf BioPhotometer plus and UVettesâ.
Eppendorf Applications Note 188, 1-5 (2008)

Shina MC, Noegel AA.
Invertebrate coronins.
Subcell. Biochem. 248, 88-97 (2008)

Lu W, Gotzmann J, Sironi L, Jaeger VM, Schneider M, Lüke Y, Uhlén M, Szigyarto CA, Brachner A, Ellenberg J, Foisner R, Noegel AA, Karakesisoglou I.
Sun1 forms immobile macromolecular assemblies at the nuclear envelope.
Biochim Biophys Acta 1783, 2415-26 (2008)

Joseph JM, Fey P, Ramalingam N, Liu XI, Rohlfs M, Noegel AA, Müller-Taubenberger A, Glöckner G, Schleicher M.
The actinome of Dictyostelium discoideum in comparison to actins and actin-related proteins from other organisms.
PLoS ONE. 3, e2654 (2008)

Rybakin V, Rastetter RH, Stumpf M, Uetrecht AC, Bear JE, Noegel AA, Clemen CS.
Molecular mechanism underlying the association of Coronin-7 with Golgi membranes.
Cell Mol Life Sci. 65, 2419-30 (2008)

Mondal S, Bakthavatsalam D, Steimle P, Gassen B, Rivero F, Noegel AA.
Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.
J Cell Biol. 181, 747-60 (2008)

Lüke Y, Zaim H, Karakesisoglou I, Jaeger VM, Sellin L, Lu W, Schneider M, Neumann S, Beijer A, Munck M, Padmakumar VC, Gloy J, Walz G, Noegel AA.
Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin.
J Cell Sci. 121, 1887-98 (2008)

Xiong H, Rivero F, Euteneuer U, Mondal S, Mana-Capelli S, Larochelle D, Vogel A, Gassen B, Noegel AA.
Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability.
Traffic 9, 708-24 (2008)

Thal D, Xavier CP, Rosentreter A, Linder S, Friedrichs B, Waha A, Pietsch T, Stumpf M, Noegel A, Clemen C.
Expression of coronin-3 (coronin-1C) in diffuse gliomas is related to malignancy.
J. Pathol. 214, 415-24. (2008)

2007

Odenthal, M., S. Koenig, P. Farbrother, U. Drebber, H.P. Dienes, Y. Bury and L. Eichinger
Detection of opportunistic infections by low-density microarrays: A diagnostic approach for granular lymphadenitis
Diagn. Mol. Pathol. 16, 18-26 (2007)

Na, J., B. Tunggal and L. Eichinger.
STATc is a major regulator of the transcriptional response to hyperosmotic shock.
BMC Genomics 8, 123 (2007)

Voolstra, C., D. Tautz, P. Farbrother, L. Eichinger and B. Harr.
Contrasting evolution of expression differences in the testis between species and subspecies of the house mouse.
Genome Res. 17, 42-49 (2007)

Kandert S, Lüke Y, Kleinhenz T, Neumann S, Lu W, Jaeger VM, Munck M, Wehnert M, Müller CR, Zhou Z, Noegel AA, Dabauvalle MC, Karakesisoglou I.
Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells.
Hum. Mol. Genet. 16, 2944-59 (2007)

Prabhu Y, Mondal S, Eichinger L, Noegel AA.
A GPCR involved in post aggregation events in Dictyostelium discoideum.
Dev. Biol. 312, 29-43 (2007)

Peche V, Shekar S, Leichter M, Korte H, Schröder R, Schleicher M, Holak TA, Clemen CS, Ramanath-Y B, Pfitzer G, Karakesisoglou I, Noegel AA.
CAP2, cyclase-associated protein 2, is a dual compartment protein.
Cell Mol. Life Sci. 64, 2702-15 (2007)

Schrickel JW, Brixius K, Herr C, Clemen CS, Sasse P, Reetz K, Grohé C, Meyer R, Tiemann K, Schröder R, Bloch W, Nickenig G, Fleischmann BK, Noegel AA, Schwinger RH, Lewalter T.
Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice.
Cardiovasc. Res. 76, 257-68 (2007)

Mondal S, Neelamegan D, Rivero F, Noegel AA.
GxcDD, a putative RacGEF, is involved in Dictyostelium development.
BMC Cell Biol. 8, 23 (2007)

Yogikala Prabhu , Rolf Müller , Christophe Anjard and Angelika A Noegel
GrlJ, a Dictyostelium GABA_B-like receptor with roles in post-aggregation development
BMC Developmental Biology 7, 44 (2007)

Bakthavatsalam, D., Brazill, D., Gomer, R. H., Eichinger, L., Rivero, F., Noegel, A. A.
A G Protein-Coupled Receptor with a Lipid Kinase Domain Is Involved in Cell-Density Sensing
Curr. Biol. 17, 892-897 (2007)

Arasada R, Gloss A, Tunggal B, Joseph JM, Rieger D, Mondal S, Faix J, Schleicher M, Noegel AA.
Profilin isoforms in Dictyostelium discoideum.
Biochim. Biophys. Acta 1773, 631-41 (2007)

Rosentreter A, Hofmann A, Xavier CP, Stumpf M, Noegel AA, Clemen CS.
Coronin 3 involvement in F-actin-dependent processes at the cell cortex.
Exp. Cell Res. 313, 878-95 (2007)

Khaire N, Müller R, Blau-Wasser R, Eichinger L, Schleicher M, Rief M, Holak TA, Noegel AA.
Filamin-regulated F-actin assembly is essential for morphogenesis and controls phototaxis in dictyostelium.
J Biol Chem. 282, 1948-55 (2007)

Hubbers CU, Clemen CS, Kesper K, Boddrich A, Hofmann A, Kamarainen O, Tolksdorf K, Stumpf M, Reichelt J, Roth U, Krause S, Watts G, Kimonis V, Wattjes MP, Reimann J, Thal DR, Biermann K, Evert BO, Lochmuller H, Wanker EE, Schoser BG, Noegel AA, Schroder R.
Pathological consequences of VCP mutations on human striated muscle.
Brain 130, 381-93 (2007).