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Publication
van Weeghel M, Te Brinke H, van Lenthe H, Kulik W, Minkler PE, Stoll MS, Sass JO, Janssen U, Stoffel W, Schwab KO, Wanders RJ, Hoppel CL, Houten SM (2012) Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids FASEB J. 26, 4316-26 Jungblut M, Tiveron MC, Barral S, Abrahamsen B, Knöbel S, Pennartz S, Schmitz J, Perraut M, Pfrieger FW, Stoffel W, Cremer H, Bosio A (2012) Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1. Glia 60, 894-907 Schraven SP, Franz C, Rüttiger L, Löwenheim H, Lysakowski A, Stoffel W, Knipper M (2012) Altered phenotype of the vestibular organ in GLAST-1 null mice. J Assoc Res Otolaryngol. 13, 323-33 María T. Dours-Zimmermann, Konrad Maurer, Uwe Rauch, Wilhelm Stoffel, Reinhard Fässler, and Dieter R. Zimmermann (2009) Versican V2 Assembles the Extracellular Matrix Surrounding the Nodes of Ranvier in the CNS The Journal of Neuroscience, 29, 7731-7742 Stoffel, W., Holz, B., Jenke, B., Binczek, E., Günter, R.H., Kiss, C., Karakesisoglou, I., Thevis, M., Weber, A.-A., Arnhold, A. and Addicks, K. (2008) D6-Desaturase (FADS2) deficiency unveils the role of w3- and w6-polyunsaturated fatty acids The EMBO Journal 27, 2281-2292 Stoffel, W., Jenke, B., Holz, B., Binczek, E., Günter, R.H., Knifka, J., Koebke, J., Niehoff, A. (2007) Neutral Sphingomyelinase (SMPD3) Deficiency Causes a Novel Form of Chondrodysplasia and Dwarfism That Is Rescued by Col2A1-Driven smpd3 Transgene Expression Am. J. Pathol. 171, 153-61. Binczek, E., Jenke, B., Holz, B., Günter R.H., Thevis, M. and Stoffel, W. (2007) Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation Biol. Chem. 388, 405-418 Stoffel, W., Jenke, B., Block, B., Zumbansen, M. & Koebke, J. (2005) Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development Proc. Natl. Acad. Sci. USA 120, 4554-4559 Wilhelm Stoffel, Rafael Körner, Dagmar Wachtmann, Stephan Tomiuk and Bernhard U. Keller (2004) Functional analysis of glutamate transporters in excitatory synaptic transmission of GLAST1 and GLAST1/EAAC1 deficient mice Molecular Brain Research, 128, 170-181 Haupt, W. and Stoffel, W. (2004) Nerve conduction velocity measurements reveal the functional deficit in ceramide galactosyltrtansferase-deficient (cgt-/-) mice J.Neurol. Sci. 217, 83-88 Spörkel , O., Uschkureit, T, Büssow, H. and Stoffel, W. (2002) Oligodendrocytes Expressing Exclusively the DM20 Isoform of the Proteolipid Protein Gene: Myelination and Development GLIA 37, 19-30 Zumbansen, M., and Stoffel, W. (2002) Neutral sphingomyelinase 1 deficiency in the mouse causes no lilpid storage disease Mol. Cell Biol. 22, 3633-3638 Spörkel , O., Uschkureit, T, Büssow, H. and Stoffel, W. (2002) Oligodendrocytes Expressing Exclusively the DM20 Isoform of the Proteolipid Protein Gene: Myelination and Development GLIA 37, 19-30 Jansen, U. and Stoffel, W. (2002) Disruption of mitochondrial ß-oxidation of unsaturated fatty acids in the 3, 2trans-enoyl-CoA isomerase deficient mouse J. Biol. Chem. 277, 19579-19584 Stoffel, W. (2002) GalCer Synthase (Ceramide Galactosyltransferase, CGT) in Handbook of Glycosyltransferases and Related Genes, pp. 51-60, ed. N.Tanigoushi, K. Honke and M. Fukuda, Springer New York Uschkureit, T., Spörkel, O., Büssow, H. and Stoffel, W. (2001) Rumpshaker-like proteolipid protein (PLP) / DM20 isoprotein ratio with compact myelin and unperturbed myelin/axon integrity in the mouse central nervous system GLIA, 35, 63-71 Hofmann, K., Tomiuk, S, Wolff, G. and Stoffel, W. (2000) Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase Proc. Natl. Acad. Sci. USA 97, 5895-5900 Uschkureit, T., Spörkel, O., Stracke, J., Büssow, H., and Stoffel, W. (2000) Early Onset of Axonal Degeneration in Double (plp-/-mag-/-) and Hypomyelinosis in Triple (plp-/-mbp-/-mag-/-) Mutant Mice J. Neuroscience 20, 5225-5233 Tomiuk, S., Zumbansen, M., and Stoffel, W. (2000) Characterization and Subcellular Localization of Murine and Human Magnesium-dependent Neutral Sphingomyelinase J. Biol. Chemistry 275, 5710-5717 Nix, M. and Stoffel, W. (2000) Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation Cell Death and Differentiation 7, 413-424 Simons, M., Kramer, E.M., Thiele, C., Stoffel, W., Trotter, J. (2000) Assembly of myelin by association of poteolipid protein with cholesterol- and galactosylceramide-rich membrane domains J. Cell Biol. 151, 143-154 Tomiuk, S., Hofmann, K., Nix, M., Zumbansen, M. and Wilhelm Stoffel (1998) Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling? Proc.Natl.Acad. Sci.USA 95, 3638-3643 Wahle, S. and Stoffel, W. (1998) Cotranslational Integration of Myelin Proteolipid Protein (PLP) into the Membrane of Endoplasmic Reticulum:Analysis of Topology by Glycosylation Scanning and Protease Domain Protection Assay GLIA 24, 226-235 Stoffel, B., Bauer, P. Nix, M., Deres, K. And Stoffel, W. (1998<)br> eramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient mice Eur. J. Immunol. 28, 874-880 Bosio, A., Büssow, H., Adam, J. Stoffel, W. (1998<)br> Galactosphingolipids and axono-glial interaction in myelin of the central nervous system Cell Tissue Res. 292, 199-210 Conradt, M. and Stoffel, W. (1997) Inhibition of High Affinity Brain Glutamate Transporter GLAST-1 via direct Phosphorylation J. Neurochem. 68, 1244-1251 Janßen, U., Davies. E.M., LeBeau, M.M. and Stoffel, W. (1997) Human Mitochondrial Enoyl.-CoA Hydratase Gene (ECHS1): Structural Organization and Assignment to Chromosome 10q26.2-q26.3 Genomics 40, 470-475 Pietro Peghini, Julia Janzen and Wilhelm Stoffel (1997) Glutamate Transporter EAAC-1-Deficient Mice Develop Dicarboxylic Aminoaciduria and Behavioral Abnormalities but no Neurodegeneration EMBO J. 16, 3822-3832 Weiss, B. and Stoffel, W. (1997) Human and Murine Serine-Palmitoyl-CoA Transferase (SPT): Cloning, Expression and Characterization of the Key Enzyme of Sphingolipid Synthesis Eur.J.Biochem.249, 239-247 Zumbansen, M. and Stoffel, W. (1997) Tumor Necrosis Factor a Activates NF-kB in Acid Sphingomyelinase-deficient Mouse Embryonic Fibroblasts J.Biol.Chem. 272, 10904-10909 Stoffel, W. and Bosio, A. (1997) Myelin glycolipids and their functions Curr.opinion in Neurobiol. 7, 654-660 Kümmel, T.A., Thiele, J., Schroeder, R. and Stoffel, W. (1997) Pathology of Visceral Organs and Bone Marrow in an Acid Sphingomyelinase Deficient Knock-Out Mouse Line, Mimicking Human Niemann-Pick Disease Type A. A Light and Electron Microscopic Study Pathology Research and Practice 193, 663-671 Stoffel, W., Boison, D. Büssow,H. (1997) Functional Analysis in Vivo of the Double Mutant Mouse Deficient in Both Proteolipid Protein (PLP) and Myelin Basic Protein (MBP) in the Central Nervous System Cell Tissue Res. 289, 195-206 Kümmel, Th.A., Schroeder, R. and Stoffel, W. (1997) Light and Electron Microscopic Analysis of the Central and Peripheral Nervous Systems of Acid Sphingomyelinase-Deficient Mice Resulting from Gene Targeting Journal of Neuropathology and Experimental Neurology 56, 171-179 Wagener, R., Kobbe, B. and Stoffel, W. (1996) Quantification of Ganglioside by Microbore High Performance Liquid Chromatography Journal of Lipid Research 37, 1823-1829 M. Hoffmann, W. Stoffel (1996) Construction and Functional Characterization of Recombinant Fusion Proteins of Human Lipoprotein Lipase and Apolipoprotein CII Eur. J. Biochem. 237, 545-552 Bosio, A., Binczek, E., Le Beau, M. M., Fernald, A., and Stoffel, W. (1996) The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26 Genomics 34: 69-75 A. Bosio, M. Binczek, W. Stoffel (1996) Molecular cloning and characerization of the mouse CGT gene encoding UDP-Glactose Ceramide-Galactosyl Transferase (Cerebroside Synthetase) Genomics, 35: 223-226 Newrzella, D. and Stoffel, W. (1996) Functional Analysis of the Glycosylation of Murine Acid Sphingomyelinase J. Biol.Chem. 271, 32089-32095 Bosio, A., Binczek, E., and Stoffel, W. (1996) Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis Proc. Natl. Acad. Sci. USA 93, 13280-13285 Stoffel, W., Sasse, J., Düker, M., Müller, R., Hofmann, K., Fink, Th., Lichter, P. (1996) Human High Affinity, Na+-Dependent L-Glutamate/L-Aspartate Transporter GLAST-1 (EAAT-1): Gene Structure and Localization to Chromosome 5p11-p12 FEBS Letters 386, 189-193 Wahle, S. and Stoffel, W. (1996) Membrane Topology of the High Affinity L-Glutamate Transporter (GLAST-1) of the Central Nervous System J.Cell Biol. 135, 1867-1877 W. Stoffel, R. Blau (1995) Rat and Human Glutamate Transporter GLAST1. Stable Heterologous Expression, Biochemical and Functional Characterization Biol. Chem. Hoppe-Seyler 376, 511-514 M. Conradt, T. Storck, W. Stoffel (1995) Localization of N-glycosylation sites and functional role of carbohydrate units of GLAST-1, a cloned rat brain L?glutamate/L-aspartate transporter Eur. J. Biochem. 229, 682-687 D. Boison, H. Büssow, D. D'Urso, H.-W. Müller and W. Stoffel (1995) Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheaths J. Neurosc., 15(8), 5502-5513 M. Conradt, W. Stoffel (1995) Functional analysis of the high-affinity, Na+-dependent glutamate transporter GLAST-1 by site-directed mutagenesis J. Biol. Chemistry, 270, No. 42, 25207-25212 R. Gutierrez, D. Boison, U. Heinemann, W. Stoffel (1995) Decompaction of CNS myelin leads to a reduction of the conduction velocity of action potentials in optic nerve Neurosc. Letters 195, 93-96 B. Otterbach, W. Stoffel (1995) Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease) Cell 81, 1053-1061 T. Weimbs, W. Stoffel (1994) Topology of CNS myelin proteolipid protein. Evidence for the non-enzymatic glycosylation of extracytoplasmic domains in normal and diabetic animals Biochem., 33, 10408-10415 W. Stoffel(1994) Molekulargenetische Wege zur Neuropathologie Deutsches Ärzteblatt, 25/26, 1340-1347 U. Janssen, T. Fink, P. Lichter, W. Stoffel (1994) Human mitochondrial 3,2-trans-enoyl-CoA isomerase (DCI): gene structure and localization to chromosome 16q13.3 Genomics 23, 223-228 D. Boison, W. Stoffel (1994) Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice Proc. Natl. Acad. Sci. USA 91, 11709-11713 G. Müller-Newen, U. Janssen, W. Stoffel (1994) Enoyl-CoA hydratase and isomerase form a superfamily with a common active site glutamate residue Eur. J. Biochem. 228, 68-73 U. Klöckner, T. Storck, M. Conradt, W. Stoffel (1994) Functional properties and substrate specificity of the cloned L-glutamate/L-aspartate transporter GLAST-1 from rat brain expressed in Xenopus oocytes J. Neurosc. 14, 5759-5765 K. Hofmann, M. Düker, Th. Fink, P. Lichter, W. Stoffel (1994) Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15 Genomics 24, 20-26 B. Otterbach, W. Stoffel (1993) A novel mutation in the proteolipid protein gene leading to Pelizaeus-Merzbacher disease Biol. Chem. Hoppe-Seyler, 374, 75-83 W. Stoffel, M. Düker, K. Hofmann (1993) Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase FEBS, 333, 119-122 G. Müller-Newen, W. Stoffel (1993) Site-directed mutagenesis of putative active site amino acid residues of 3,2-trans-enoyl-CoA isomerase, conserved within the low homology isomerase/hydratase enzyme family Biochem., 32, 11405-11412 U. Klöckner, T. Storck, M. Conradt, W. Stoffel Electrogenic L-glutamate uptake in Xenopus laevis oocytes expressing a cloned rat brain L-glutamate/L-aspartate transporter (GLAST-1) J. Biol. Chem., 268, 14594-14596 (1993) R. Janz, W. Stoffel (1993) Characterization of a brain-specific SP1-like activity interacting with an unusual binding site within the myelin proteolipid protein promoter Biol. Chem. Hoppe-Seyler, 374, 507-517 S. Schulte, W. Stoffel (1993) Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression Proc.Natl. Acad. Sci. USA, 90, 10265-10269 W. Stoffel, R. Müller, E. Binczek, K. Hofmann (1992) Mouse-apolipoprotein AI. cDNA-derived primary structure, gene organization, and complete nucleotide-sequence Biol. Chem. Hoppe-Seyler, 373, 187-193 K. Hofmann, W. Stoffel (1992) Profilegraph: an interactive graphical tool for protein sequence analysis. Comput. Applic. Biosci., 8, 331-337 T. Weimbs, W. Stoffel (1992) Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide bonded, and fatty acid thioester-linked cysteine residues. Implications for the membrane topology of PLP Biochem., 31, 12289-12296 B. Tunggal, K. Hofmann, W. Stoffel, K. Oette, H. Diekmann, M. Walger, H. von Wedel. (1992) In vivo nuclear magnetic resonance at 4.7 tesla Naturwissenschaften, 79, 512-516 D. Newrzella, W. Stoffel (1992) Molecular cloning of the acid sphingomyelinase of the mouse and the organization and complete nucleotide sequence of the gene. Biol. Chem. Hoppe-Seyler, 373, 1233-1238 H. Bruhns, W. Stoffel (1991) An approach to the functional analysis of lecithin-cholesterol acyltransferase. Activation by recombinant normal and mutagenized apolipoprotein AI Biol. Chem. Hoppe-Seyler, 372, 225-234 J. Kurth, W. Stoffel (1991) Human placental sphingomyelinase. Purification to homogeneity, antigenic properties, and partial amino-acid sequences of the enzyme Biol. Chem. Hoppe-Seyler, 372, 215-223 W. Stoffel, E. Binczek (1991) Transient expression of wild type and mutant human apolipoprotein AI in COS cells Biol. Chem. Hoppe-Seyler, 372, 481-488 G. Müller-Newen, W. Stoffel (1991) Mitochondrial 3-2trans-enoyl-CoA isomerase. Purification, cloning, expression, and mitochondrial import of key enzyme of unsaturated fatty acid b-oxidation Biol. Chem. Hoppe-Seyler, 372, 613-624 F. Schließ, W. Stoffel (1991) Evolution of the myelin integral membrane proteins of the central nervous system Biol. Chem. Hoppe-Seyler, 372, 865-874 prior publication November 15, 2012 Zentrum für Biochemie, Joseph-Stelzmann-Straße 52, D50931 Köln Kritik und Anregungen: Budi Tunggal Telefon: +49 221 4786930, Telefax: +49 221 4786979  |