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Cellular Homeostasis

Recent publications

  1. Xing X, Mroß C, Hao L, Munck M, Herzog A, Mohr C, Unnikannan CP, Kelkar P, Noegel AA, Eichinger L and Neumann S. Nesprin-2 interacts with condensin component SMC2. Int. J. Cell Biol. Article ID 8607532 (2017)

  2. Li P, Stumpf M, Müller R, Eichinger L, Glöckner G, Noegel AA. The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation. Scientific Reports 7:9157 (2017)

  3. Mesquita A, Cardenal-Muñoz E, Dominguez E, Muñoz-Braceras S, Nuñez-Corcuera B, Philips BA, Tábara LC, Xiong Q, Coria R, Eichinger L, Golstein P, King JS, Soldati T, Vincent O, Escalante R. Autophagy in Dictyostelium: mechanisms, regulation and disease in a simple biomedical model. Autophagy 13, 24-40 (2017)

  4. Meßling S, Matthias J, Xiong Q, Fischer S, Eichinger L. The two Dictyostelium discoideum autophagy 8 proteins have distinct autophagic functions. Eur J Cell Biol. 96, 312-324 (2017)

  5. Stumpf M, Müller R, Gaßen B, Wehrstedt R, Fey P, Karow MA, Eichinger L, Glöckner G, Noegel AA. A tripeptidyl peptidase 1 is a binding partner of the Golgi pH regulator (GPHR) in Dictyostelium. Dis Model Mech. 10, 897-907 (2017)

  6. Burgute BD, Peche VS, Müller R, Matthias J, Gaßen B, Eichinger L , Glöckner G, Noegel AA. The C-terminal SynMuv/DdDUF 926 domain regulates the function of the N-terminal domain of DdNKAP. PLOS ONE 11:e0168617 (2016)

  7. Schilde C, Lawal H, Noegel AA, Eichinger L, Schaap P, Glöckner G. A set of genes conserved in sequence and expression traces back the establishment of multicellularity in social amoebae. BMC Genomics 17, 871 (2016)

  8. Rijal R, Arhzaouy K, Strucksberg K-H, Cross M, Hofmann A, Schröder R, Clemen* CS, Eichinger* L. Mutant p97 exhibits species-specific changes of its ATPase activity and compromises the UBXD9-mediated monomerisation of p97 hexamers. Eur J Cell Biol. 95, 195-207 (2016) *Co-senior authors

  9. Klionsky DJ, Abdelmohsen K, Abe A, ……… Eichinger L, ……… Zorzano A and Zughaier SM (in total 2465 authors). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12, 1-222 (2016)

  10. Matthias, J., S. Meßling, and L. Eichinger. The two Dictyostelium autophagy eight proteins, ATG8a and ATG8b, associate with the autophagosome in succession. Eur J Cell Biol. 95, 15-25 (2016)

  11. Bührdel JB, Hirth S, Keßler M, Westphal S, Forster M, Manta L, Wiche G, Schoser B, Schessl J, Schröder R, Clemen CS, Eichinger L, Fürst DO, van der Ven PFM, Rottbauer W, Just S. In vivo characterization of human myofibrillar myopathy genes in zebrafish. Biochem Bioph Res Commun. 461, 217-223 (2015)

  12. Clemen CS, Marko M, Strucksberg KH, Behrens J, Wittig I, Gärtner L, Winter L, Chevessier F, Matthias J, Türk M, Tangavelou K, Schütz J, Arhzaouy K, Klopffleisch K, Hanisch FG, Rottbauer W, Blümcke I, Just S, Eichinger L, Hofmann A, Schröder R. VCP and PSMF1: Antagonistic regulators of proteasome activity. Biochem Bioph Res Commun. 463, 1210-1217 (2015)

  13. Deckstein J, van Appeldorn J, Tsangarides M, Yiannakou K, Müller R, Stumpf M, Sukumaran SK, Eichinger L, Noegel AA, Riyahi TY. The Dictyostelium discoideum GPHR ortholog is an ER and Golgi protein with roles during development. Eukaryot Cell. 14, 41-54 (2015)

  14. Rastetter RH, Blömacher M, Drebber U, Marko M, Behrens J, Solga R, Hojeili S, Bhattacharya K, Wunderlich CM, Wunderlich FT, Odenthal M, Ziemann A, Eichinger L, Clemen CS. Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. BMC Cancer. 15, 638 (2015)

  15. Simon S, Schell U, Heuer N, Hager D, Albers MF, Matthias J, Fahrnbauer F, Trauner D, Eichinger L, Hedberg C, and Hilbi H. Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway. PloS Pathog. 11, e1005307 (2015)

  16. Swaminathan K, Stumpf M, Müller R, Horn AC, Schmidbauer J, Eichinger L, Müller-Taubenberger A, Faix J, Noegel AA. Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins. Scientific Reports 5, 14437 (2015)

  17. Xiong Q, Can U, Matthias J, Steinert M and Eichinger L. The phenotypes of ATG9, ATG16 andATG9/16 knock-out mutants imply autophagy-dependent and –independent functions Open Biol. 5, 150008 (2015)

  18. Araki T, Vu LH, Sasaki N, Kawata T, Eichinger L and Williams JG. Two Dictyostelium Tyrosine Kinase-Like kinases function in parallel, stress-induced STAT activation pathways. Mol. Biol. Cell. 25, 3222-3233 (2014)

  19. Glöckner G, Hülsmann N, Schleicher M, Noegel AA, Eichinger, L, Gallinger C, Pawlowski J, Sierra R, Euteneuer U, Pillet L, Moustafa A, Platzer M, Groth M, Szafranski K and Schliwa M. The Genome of the foraminiferan Reticulomyxa filosa. Curr Biol. 24, 11-8 (2014)

  20. Vu LH, Araki T, Na J, Clemen CS, Williams JG and Eichinger L. Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc mediated response to hyperosmolarity. PLoS ONE 25;9(2):e90025 (2014)

  21. Junemann A, Nordholz B, Winterhoff M, Rottner K, Eichinger L, Gräf R and Faix J. ForC lacks formin activity but is required for chemotaxis and multicelluar development of Dictyostelium cells. Eur. J. Cell Biol. 92, 201-212 (2013)

  22. Klionsky, DJ. and 1269 others. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8:4, 1-100 (2012)

  23. Clemen CS, Eichinger L and Schröder R. Reply: Hereditary spastic paraplegia caused by a mutation in the VCP gene - VCP: A jack of all trades in neuro- and myodegeneration? Brain 135, 1-3 (2012)

  24. Arhzaouy K, Strucksberg KH, Tung SM, Tangavelou K, Stumpf M, Faix J, Schröder R, Clemen CS, and Eichinger L. Heteromeric p97/p97R155C complexes induce dominant negative changes in wild-type and autophagy 9-deficient Dictyostelium strains. PLoS ONE 10, e46879 (2012)

  25. Chang GS, Noegel AA, Mavrich TN, Müller R, Tomsho L, Ward E, Felder M, Jiang C, Eichinger L, Glöckner G, Schuster SC, Pugh BF. Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium. Genome Res. 22, 1098-1106. (2012)

  26. Xavier CP, Rastetter RH, Blömacher M, Stumpf M, Himmel M, Morgan RO, Fernandez MP, Wang C, Osman A, Miyata Y, Gjerset RA, Eichinger L, Hofmann A, Linder S, Noegel AA, Clemen CS. Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration. Sci Rep. 2, 241 (2012)

  27. Rashmi RN, Eckes B, Glöckner G, Groth M, Neumann S, Gloy J, Sellin L, Walz G, Schneider M, Karakesisoglou I, Eichinger L, Noegel AA. The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing. Nucleus 3, 172-186 (2012)

  28. Sillo A, Matthias J, Konertz R, Bozzaro S, Eichinger L. Salmonella typhimurium is pathogenic for Dictyostelium cells and subverts the starvation response. Cell Microbiol. 13, 1793-1811 (2011)

  29. Heidel A, Lawal H, Felder M, Schilde C, Helps N, Tunggal B, Rivero F, John U, Schleicher M, Eichinger L, Platzer M, Noegel A, Schaap P, Glöckner G. Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res. 21, 1882-91 (2011)

  30. Riyahi TY, Frese F, Steinert M, Omosigho N N, Glöckner G, Eichinger L, Orabi B, Williams RSB, Noegel AA. RpkA, a highly conserved GPCR with a lipid kinase domain, has a role in phagocytosis and anti-bacterial defense. PLoS One 6, e27311 (2011)

  31. Sucgang R, Kuo A, Tian X, Salerno W, Parikh A, Feasley CL, Dalin E, Tu H , Huang E, Barry K, Lindquist E, Shapiro H, Bruce D, Schmutz J, Salamov A, Fey P, Gaudet P, Anjard C, Babu MM, Basu S, Bushmanova Y, van der Wel H, Katoh-Kurasawa M, Dinh C, Coutinho PM, Saito T, Elias M, Schaap P, Kay RR, Henrissat B, Eichinger L, Rivero F, Putnam NH, West CM, Loomis WF, Chisholm RL, Shaulsky G, Strassmann JE, Queller DC, Kuspa A, Grigoriev IV. Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum. Genome Biol. 12, R20 (2011)

  32. Shina, M.C., A. Müller-Taubenberger, C. Ünal, M. Schleicher, M. Steinert, L. Eichinger, R Müller, G. Glöckner, and A.A. Noegel. Redundant and unique roles of coronin proteins in Dictyostelium. Cell. Mol. Life Sci. 68, 303-313 (2011)

  1. Mesquita, A., E. Cardenal-Muñoz, E. Dominguez, S. Muñoz-Braceras, B. Nuñez-Corcuera, B.A. Philips, L.C. Tábara, Q. Xiong, R. Coria, L. Eichinger, P. Golstein, J.S. King, T. Soldati, O. Vincent, and R. Escalante. Autophagy in Dictyostelium: mechanisms, regulation and disease in a simple biomedical model. Autophagy 13, 24-40 (2017)

  2. Müller-Taubenberger A, Kortholt A and Eichinger L. Simple System - Substantial Share: The use of Dictyostelium in cell biology and molecular medicine. Eur. J. Cell Biol. 92, 45-53 (2013)

  3. Eichinger L. Model organisms to study host - pathogen interaction: prerequisites for the identification of novel drug targets. Curr. Drug Targets 12, 934-935 (2011)

  4. Bozzaro, S. and L. Eichinger. The professional phagocyte Dictyostelium discoideum as a model host for bacterial pathogens. Curr. Drug Targets 12, 942-954 ( 2011)

  5. Prabhu, Y. and L. Eichinger. The Dictyostelium repertoire of seven transmembrane domain receptors. Eur. J. Cell Biol., 85:937-946 (2006)

  6. Duden, R. and L. Eichinger. Meeting Report : Vesicular Trafficking - 7th Young Scientists Meeting of the German Society for Cell Biology (DGZ). Eur. J. Cell Biol., 85:133-140 (2006)

  7. Eichinger, L. and A.A. Noegel. Comparative genomics of Dictyostelium discoideum and Entamoeba histolytica. Curr. Opin. Microbiol., 8:606-611 (2005)

  8. Williams, J.G., A.A. Noegel and L. Eichinger. Manifestations of multicellularity - Dictyostelium reports in. TIGS, 21:392-398 (2005)

  9. Eichinger, L. Revamp a model - status and prospects of the Dictyostelium genome project. Curr. Genet. 44:59-72 (2003)

  10. Eichinger, L. and A.A. Noegel. Crawling into a new era - the Dictyostelium genome project. EMBO J., 22:1941-1946 (2003)


  1. Bozzaro S, Peracino B and Eichinger L.
    Dictyostelium host response to Legionella infection: strategies and assays. Methods Mol. Biol. 954, 417-438 (2013)

  2. Clemen, C.S., V. Rybakin and L. Eichinger
    The Coronin Family of Proteins
    In: The Coronin Protein Family. Eds: C.C. Clemen, L. Eichinger and V. Rybakin, Landes Bioscience, Austin, Texas and Springer Science+Business Media, New York, USA, 1-5 (2008)


  3. Xavier, C-P., L. Eichinger, M.P. Fernandez, R.O. Morgan and C.S. Clemen
    Evolutionary and functional diversity of coronin proteins
    In: The Coronin Protein Family. Eds: C.C. Clemen, L. Eichinger and V. Rybakin, Landes Bioscience, Austin, Texas and Springer Science+Business Media, New York, USA, 98-109 (2008)

  4. Christoph C. Clemen, Ludwig Eichinger and Vasily Rybakin, editors.
    The Coronin Protein Family.
    Landes Bioscience, Austin, Texas and Springer Science+Business Media, New York, USA (2008)

  5. Steinert, M., C. Wagner, M. Fajardo, O. Shevchuk, C. Ünal, F. Galka, K. Heuner, L. Eichinger and S. Bozzaro.
    The Amoeba Dictyostelium discoideum Contributes to Legionella Infection. In Legionella: State of the art 30 years after its recognition. Eds.: N.P. Cianciotto, Y. Abu Kwaik, P.H. Edelstein, B.S. Fields, D.F. Geary, T.G. Harrison, C. Joseph, R.M. Ratcliff, J.E. Stout and M.S. Swanson. ASM Press, Herndon, USA, 390-394 (2007)

  6. L. Eichinger, F. Rivero, editors.
    Dictyostelium discoideum. Methods and Protocols.
    In Methods in Molecular Biology Vol. 346. Humana Press, Totowa, New Jersey (2006)


  7. Kaul M. and L. Eichinger
    Analysis of gene expression using cDNA microarrays
    In Methods in Molecular Biology, Dictyostelium discoideum, Eds.: L. Eichinger and F. Rivero. Humana Press, Totowa: pp. 75-93 (2006)

  8. Rivero, F. and L. Eichinger
    The Microfilament System of Dictyostelium discoideum
    In Dictyostelium Genomics, Eds.: W.F. Loomis and A. Kuspa, Horizon Scientific Press, Norfolk, UK, 125-172 (2005)

Prior publication

February 27, 2018
Ludwig Eichinger
Institute for Biochemistry I, Joseph-Stelzmann-Strasse 52, D50931 Cologne
Suggestions and wishes: Gudrun Konertz