Gruppe Hanisch  
Publikation


  1. Rollenhagen M, Buettner FF, Reismann M, Jirmo AC, Grove M, Behrens GM, Gerardy-Schahn R, Hanisch FG, Mühlenhoff M. (2013)
    Polysialic acid on neuropilin-2 Is exclusively synthesized by the polysialyltransferase ST8SiaIV and attached to mucin-type O-glycans located between b2 and c domain.
    J Biol Chem. 2013 Jun 25. [Epub ahead of print]

  2. Razawi H, Kinlough CL, Staubach S, Poland PA, Rbaibi Y, Weisz OA, Hughey RP, Hanisch FG. (2013)
    Evidence for core 2 to core 1 O-glycan remodeling during the recycling of MUC1.
    Glycobiology. 23:935-45

  3. Bellwied P, Staubach S, Hanisch FG. (2013)
    Chemical in-gel deglycosylation of O-glycoproteins improves their staining and mass spectrometric identification. (2013)
    Electrophoresis. 2013 Apr 12. doi: 10.1002/elps.201200647. [Epub ahead of print]

  4. Feldkirchner S, Walter MC, Müller S, Kubny C, Krause S, Kress W, Hanisch FG, Schoser B, Schessl J. (2013)
    Proteomic characterization of aggregate components in an intrafamilial variable FHL1-associated myopathy
    Neuromuscul Disord. 23, 418-26

  5. Pacharra S, Hanisch FG, Mühlenhoff M, Faissner A, Rauch U, Breloy I (2013)
    The lecticans of mammalian brain perineural net are O-mannosylated
    J. Proteome Res. in print.

  6. Schroten, M., Hanisch, F.G., Quednau, N., Stump, C., Riebe, R., Lenk, M., Wolburg, H., Tenebaum, T., and Schwerk, C. (2012)
    O novel porcine in vitro model of the blood-cerebrospinal fluid barrier with strong barrier function
    PLoS ONE 7, e39835.

  7. Pacharra, S., Hanisch, F.G. and Breloy, I. (2012)
    Neurofacsin 186 is O-mannosylated within and outside of the mucin domain
    J. Proteome Res. 11, 3955-3964.

  8. Feldkirchner, S., Schessl, J., Müller, S., Schoser, B., and Hanisch, F.G. (2012)
    Patient-specific protein aggregates in myofibrillar myopathies: laser microdissection and differential proteomics for identification of plaque.
    components.Proteomics 12, 3598-3609.

  9. Breloy, I., Pacharra, S., Aust, C., and Hanisch, F.G. (2012)
    A sensitive gel-based global O-glycomics approach reveals high levels of mannosyl glycans in the high mass region of the mouse brain proteome.
    Biol. Chem. 393, 709-717.

  10. Breloy, I., Pacharra, S., Ottis, P., Bonar, D., Grahn, A., and Hanisch, F.G. (2012)
    O-linked N,N´-diacetyllactosamine (LacdiNAc)-modified glycans in extracellular matrix glycoproteins are specifically phosphorylated at subterminal N-acetlyglucoseamine.
    J. Biol. Chem. 287, 18275-18286.

  11. Lehr, S., Hartwig, S., Lamers, D., Famulla, S., Müller, S., Hanisch, F.-G., Cuvelier, C., Ruige, J., Eckardt, K., Ouwens, D.M., Sell, H., Eckel, J. (2012)
    Identification and validation of novel adipokines released from primary human adipocytes.
    Mol. Cell. Proteomics. 11, M111.010504

  12. Hanisch, F.-G. (2012)
    O-Glycoproteomics: site-specific O-glycoprotein analysis by CID/ETD electrospray ionization tandem mass spectrometry and top-down glycoprotein sequencing by in-source decay MALDI mass spectrometry.
    Meth. Mol. Biol. 842, 179-189

  13. Hanisch, F.-G., Kinlough, C.L., Staubach, S., Hughey, R.P. (2012)
    MUC1 membrane trafficking: protocols for assessing biosynthetic delivery, endocytosis, recycling, and release trough exosomes.
    Meth. Mol. Biol. 842, 123-140

  14. Staubach, S., Schadewaldt, P., Wendel, U., Nohroudi, K., Hanisch, F.-G. (2012)
    Differential glycomics of epithelial membrane glycoproteins from urinary exovesicles reveals shifts toward complex-type N-glycosylation in classical galactosemia.
    J. Proteome Res. 11, 906-916

  15. Rech, C, Rosencrantz, RR; Krenek, K, Pelantova, H, Bojarova, P, Romer, CE; Hanisch, FG; Kren, V; Elling, L. (2011)
    Combinatorial One-Pot Synthesis of Poly-N-acetyllactosamine Oligosaccharides with Leloir-Glycosyltransferases.
    Adv. Synth. Catal. 353, 2492-2500.

  16. Hanisch, F.-G. (2011)
    Chemical de-O-glycosylation of glycoproteins for applications in LC-based proteomics.
    Meth. Mol. Biol. 753, 323-333

  17. Lamers, D., Famulla, S., Wronkowitz, N., Hartwig, S., Lehr, S., Ouwens, D.M., Eckardt, K., Kaufmann, J.M., Ryden, M., Müller, S., Hanisch, F.-G., Ruige, J., Arner, P., Sell, H., Eckel, J. (2011)
    Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome.
    Diabetes 60, 1917-1925

  18. Hanisch, F.-G. (2011)
    Top-down sequencing of O-glycoproteins by in-source decay matrix-assisted laser desorption ionization mass spectrometry for glycosylation site analysis.
    Anal. Chem. 83, 4829-4837

  19. Clemen, C.S., Tangavelou, K., Strucksberg, K.H., Just, S., Gaertner, L., Regus-Leidig, H., Stumpf, M., Reimann, J., Coras, R., Morgan, R.O., Fernandez, M.P., Hofmann, A., Müller, S., Schoser, B., Hanisch, F.-G., Rottbauer, W., Blümcke, I., von Hörsten, S., Eichinger, L., Schröder, R. (2010)
    Strumpellin is a novel valosin-conraining protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.
    Brain 133, 2920-2941

  20. Albert, T.K., Laubinger, W., Müller, S., Hanisch, F.-G., Kalinski, T., Meyer, F., Hoffmann, W. (2010)
    Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfide.
    J. Proteome Res. 9, 3108-3117

  21. Roth, U., Razawi, H., Hommer, J., Engelmann, K., Schwientek, T., Müller, S., Baldus, S.E., Patsos, G., Corfield, A.P., Paraskeva, C., Hanisch, F.-G. (2009)
    Differential expression proteomics of colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma.
    Proteomics 10, 194-202

  22. Hanisch, F.-G. (2009)
    Highlight: Perspectives in Glycobiology.
    Biol. Chem. 390, 519-520

  23. Staubach, S., Razawi, H., Hanisch, F.-G. (2009)
    Proteomics of MUC1 containing lipd rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7.
    Proteomics 9, 2820-2835

  24. Hanisch, F.-G., Breloy, I. (2009)
    Protein-specific glycosylation: signal patches and cis-controlling peptidic elements.
    Biol. Chem. 390, 619-626

  25. Hanisch, F.-G., Müller, S. (2009)
    Analysis of methylated O-glycan alditols by reversed-phase Nano-LC coupled CAD-ESI mass spectrometry.
    Methods Mol. Biol. 534, 107-115

  26. Hanisch, F.-G., Teitz, S., Schwientek, T., Müller, S. (2009)
    Chemical de-O-glycosylation of glycoproteins for application in LC-based proteomics.
    Proteomics 9, 710-719

  27. Chung, B.D., Kayserili, H., Ai, M., Freudenberg, J., Üzümcü, A., Uyguner, O., Bartels, C.F., Höning, S., Ramirez, A., Hanisch, F.G., Nürnberg, G., Nürnberg, P., Warman, M.L., Wollnik, B., Kubisch, C., Netzer, C. (2008)
    A mutation in the signal sequence of LRP5 in a family with an OPPG-like phenotype indicates a novel disease mechanism for trinucleotide repeats.
    Hum Mutation 30, 641-648

  28. Ninkovic, T., Kinarsky, L., Engelmann, K., Pisarev, V., Sherman, S., Finn, O.J., Hanisch, F.-G. (2008)
    Identification of O-glycosylated decapeptides within the MUC1 repeat domain as potential MHC class I (A2) binding epitopes.
    Mol. Immunol. doi:10.1016/j.molimm.2008.09.032 [Epub ahead of print]

  29. Breloy, I., Schwientek, T., Gries, B., Macht, M., Albers, C., Hanisch, F.-G. (2008)
    Initiation of mammalian O-mannosylation in vivo is independent of a consensus sequence, and controlled by peptide regions within and upstream of the a-dystroglycan mucin domain.
    J. Biol. Chem. 283, 18832-18840

  30. Gebauer, J., Müller, S., Hanisch, F.-G., Paulsson, M., Wagener, R. (2008)
    O-Glucosylation and O-fucosylation occur together in close proximity on the first EGF repeat of AMACO (VWA2).
    J. Biol. Chem. 283, 17846-17854

  31. Breloy, I., Schwientek, T., Lehr, S., Hanisch, F.-G. (2008)
    Glucuronic acid can extend O-linked core 1 glycans, but it contributes only weakly to the negative surface charge of Drosophila melanogaster Schneider-2 cells.
    FEBS-Lett. 582, 1593-1598

  32. Stork, R., Zettlitz, K.A., Müller, D., Rether, M., Hanisch, F.-G., Kontermann, R.E. (2008)
    N-Glycosylation as novel strategy to improve pharmacokinetic properties of bispecific single-chain diabodies.
    J. Biol. Chem. 283, 7804-7812

  33. Schwientek, T., Mandel, U., Roth, U., Müller, S., Hanisch, F.G. (2007)
    A serial lectin approach to the mucin-type O-glycoproteome of Drosophila melanogaster S2 cells.
    Proteomics 7, 3264-3277

  34. Ninkovic, T., Hanisch, F.G. (2007)
    O-glycosylated human MUC1 repeats are processed in vitro by immunoproteasomes.
    J Immunol. 179, 2380-2388

  35. Kobayashi, N., Kostka, G., Garbe, J.H., Keene, D.R., Bachinger, H.P., Hanisch, F.G., Markova, D., Tsuda, T., Timpl, R., Chu, M.L., Sasaki, T. (2007)
    A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization.
    J Biol. Chem 282, 11805-11816

  36. Baldus, S.E., Monig, S.P., Zirbes, T.K., Thakran, J., Kothe, D., Koppel, M., Hanisch, F.-G., Thiele, J., Schneider, P.M., Holscher, A.H., Dienes, H.P. (2006)
    Lewis(y) antigen (CD174) and apoptosis in gastric and colorectal carcinomas: correlations with clinical and prognostic parameters.
    Histol. Histopathol. 21, 503-510

  37. Stalz, H., Roth, U., Schleuder, D., Macht, M., Haebel, S., Strupat, K., Peter-Katalinic, J., Hanisch, F.-G. (2006)
    The Geodia cydonium galectin exhibits prototype and chimera-type characteristics and a unique sequence polymorphism within its carbohydrate recognition domain.
    Glycobiology 16, 402-414

  38. Baldus, S.E., Wienand, J.R., Werner, J.P., Landsberg, S., Drebber, U., Hanisch, F.-G., Dienes, H.P. (2005)
    Expression of MUC1, MUC2 and oligosaccharide epitopes in breast cancer: prognostic significance of a sialylated MUC1 epitope.
    Int. J. Oncol. 27, 1289-1297

  39. Julien, S., Adriaenssens, E., Ottenberg, K., Fulan, A., Courtand, G., Edouart, A.S., Hanisch, F.-G., Delannoy, P., Bourhis, X.L. (2005)
    ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity.
    Glycobiology 16, 54-64

  40. Hanisch, F.-G. (2005)
    Design of a MUC1-bsed cancer vaccine.
    Biochem. Soc. Trans. 33, 705-708

  41. Carlos, C., Dong, H.F., Howard, O.M.Z., Oppenheim, J.J., Hanisch, F.-G., Finn, O.J. (2005)
    Human tumor antigen MUC1 is chemotactic for immataure dendritic cells and elicits maturation but does not promoteTh1 type immunity.
    J. Immunol. 175, 1628-1635

  42. Engelmann, K., Kinlough, C.L., Müller, S., Razawi, H., Baldus, S.E., Hughey, R.P., Hanisch, F-G. (2005)
    Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles.
    Glycobiology 15, 1111-1124

  43. Von Mensdorff-Pouilly, S., Kinarsky, L., Engelmann, K., Baldus, S.E., Verheijen, R.H., Hollingsworth, M.A., Pisarev, V., Sherman, S., Hanisch, F.-G. (2005)
    Sequence-variant repeats of MUC1 show higher conformational flexibility, are less densely O-glycosylated and induce differential B lymphcyte responses.
    Glycobiology 15, 735-746

  44. Lehr, S., Kotzka, J., Avci, H., Knebel, B., Müller, S., Hanisch, F-G., Jacob, S., Haak, C., Susanto, F., Muller-Wieland, D. (2005)
    Effect of sterol regulatory element binding protein-1a on the mitochondrial protein pattern in human liver cells detected by 2D-DIGE.
    Biochemistry 44 (13), 5117-5128

  45. Pisarev, V.M., Kinarsky, L., Caffrey, T., Hanisch, F-G., Sanderson, S., Hollingsworth, M.A., Sherman, S. (2005)
    T cells recognize PD(N/T)R motif common in a variable number of tandem repeat and degenerate repeat sequences of MUC1.
    Int. Immunopharmacol. 5 (2) 315-330

  46. Kaufmann, B., Müller, S., Hanisch, F-G., Hartmann, U., Paulsson, M., Maurer, P., Zaucke, F. (2004)
    Structural variability of BM-40/SPARC/osteonectin glycosylation: implications for collagen affinity.
    Glycobiology 14, 609-619

  47. Baldus, S.E., Mönig, S.P., Huxel, S., Landsberg, S., Hanisch, F-G., Engelmann, K., Schneider, P.M., Thiele, J., Hölscher, A.H., Dienes, H.P. (2004)
    MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis.
    Clin. Cancer Res. 10 (8), 2790-2796

  48. Hambrock HO, Kaufmann B, Muller S, Hanisch FG, Nose K, Paulsson M, Maurer P, Hartmann U. (2004)
    Structural characterization of TSC-36/Flik: analysis of two charge isoforms.
    J Biol Chem. 279, 11727-11735

  49. Kaufmann B, Müller S, Hanisch FG, Hartmann U, Paulsson M, Maurer P, Zaucke F. (2004)
    Structural variability of BM-40/SPARC/osteonectin glycosylation: implications for collagen affinity.
    Glycobiology 14, 609-619

  50. Baldus SE, Monig SP, Huxel S, Landsberg S, Hanisch FG, Engelmann K, Schneider PM, Thiele J, Holscher AH, Dienes HP. (2004)
    MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis.
    Clin. Cancer Res. 10, 2790-2796

  51. Hanisch, F.-G., Schwientek, T., Von Bergwelt-Baildon, M., Schultze, J.L., Finn, O.J. (2003)
    O-Linked glycans control glycoprotein processing by antigen-presenting cells: a biochemical approach to the molecular aspects of MUC1 processing by dendritic cells.
    Eur. J. Immunol. 33, 3242-3254

  52. Heuser, C., Ganser, M., Hombach, A., Brand, H., Denton, G., Hanisch, F.-G., Abken, H. (2003)
    An anti-MUC1-antibody-interleukin-2 fusion protein that activates resting NK cells to lysis of MUC1-positive tumor cells.
    Br. J. Cancer 89, 1130-1139

  53. Kinarsky, L., Suryanarayanan, G., Prakash, O., Paulsen, H., Clausen, H., Hanisch, F.-G., Hollingsworth, M.A., Sherman, S. (2003)
    Conformational studies on the MUC1 tandem repeat glycopeptides: implication for the enzymatic O-glycosylation of the mucin protein core.
    Glycobiology 13, 929-939

  54. Grohmann, G.P., Schirmacher, P., Manzke, O., Hanisch, F.-G., Dienes, H.P., Baldus, S.E. (2003)
    Modulation of MUC1 and blood group antigen expression in gastric adenocarcinoma cells by cytokines.
    Cytokine 23, 86-93

  55. Bornemann, C., Burggraef, T., Heimbüchel, G., Hanisch, F.-G., Winkels, S. (2003)
    Fluorescence-labelled antigen-binding fragments (Fab) from monoclonal antibody 5F12 detect human erythropoietin in immunoaffinity capillary electrophoresis.
    Anal. Bioanal. Chem. 376, 1074-1080

  56. Solzbacher, D., Hanisch, F.-G., van Alphen, L., Gilsdorf, J.R., Schroten, H. (2002)
    Mucin in middle ear effusions inhibits attachment of Haemophilus influenzae to mucosal epithelial cells.
    Eur. Arch. Otorhinolaryngol. 260, 141-147

  57. Vlad, A.M., Müller, S., Cudic, M., Paulsen, H., Otvos, L., Hanisch, F.-G., Finn, O.J. (2002)
    Complex carbohydrates are not removed during processing of glycoproteins by dendritic cells: Processing of tumor antigen MUC1 glycopeptides for presentation to MHC class II-restricted T cells.
    J. Exp. Med. 196, 1-13

  58. Baldus, S.E., Hanisch, F.-G., Putz, C., Flucke, U., Monig, S.P., Schneider, P.M., Thiele, J., Holscher, A.H., Dienes, H.P. (2002)
    Immunoreactivity of Lewis blood group and mucin peptide core antigens: correlations with grade of dysplasia and malignant transformation in the colorectal adenoma-carcinoma sequence.
    Histol. Histopathol. 17, 191-198

  59. Baldus, S.E., Monig, S.P., Hanisch, F.-G., Zirbes, T.K., Flucke, U., Oelert, S., Zilkens, G., Madejczik, B., Thiele, J., Schneider, P.M., Holscher, A.H., Dienes, H.P. (2002)
    Comparative evaluation of the prognostic value of MUC1, MUC2, sialyl-Lewis(a) and sialyl-Lewis(x) antigens in colorectal adenocarcinoma.
    Histopathology 40, 440-449

  60. Takeuchi, H., Kato, K., Denda-Nagai, K., Hanisch, F.-G., Clausen, H., Irimura, T. (2002)
    The epitope recognized by the unique anti-MUC1 monoclonal antibody MY.1E12 involves sialyl alpha 2-3 galactosyl beta 1-3 N-acetylgalactosaminide linked to a distinct threonine residue in the MUC1 tandem repeat.
    J. Immunol. Methods 270, 199-209

  61. Baldus, S.E., Monig, S.P., Arkenau, V., Hanisch, F.-G., Schneider, P.M., Thiele, J., Holscher, A.H., Dienes, H.P. (2002)
    Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma.
    Ann. Surg. Oncol. 9, 887-893

  62. Müller, S., Hanisch, F.-G. (2002)
    Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin: high-density and prevalent core2-based O-glycosylation.
    J. Biol. Chem. 277, 26103-26112

  63. Wuttke, M., Müller, S., Nitsche, D.P., Paulsson, M., Hanisch, F.-G., Maurer, P. (2001)
    Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding.
    J. Biol. Chem. 276, 36839-36848

  64. Engelmann, K., Baldus, S.E., Hanisch, F.-G. (2001)
    Identification and topology of variant sequences within individual repeat domains of the human epithelial tumor mucin MUC1.
    J. Biol. Chem. 276, 27764-27769
  65. Soares, M., Hanisch, F.-G., Finn, O.J., Ciborowski, P. (2001)
    Recombinant human tumor antigen MUC1 expressed in insect cells: structure and immunogenicity.
    Protein Expression and Purification 22, 92-100

  66. Hanisch, F.-G., Reis, C.A., Clausen, H., Paulsen, H. (2001)
    Evidence for glycosylation-dependent activity of polypeptide N-acetylgalactosaminyl-transferases rGalNAc-T2 and -T4 on mucin glycopeptides.
    Glycobiology 11, 731-740

  67. Stalz, H., Haebel, S., Macht, M., König, S., Peter-Katalinic, J. (2001)
    Primary structure of allelic protein variants of an ancestral galectin with type2-CRD from the sponge Geodia cydonium.
    Glycobiology, eingereicht

  68. Hanisch, F.-G. (2001)
    O-Glycosylation of the mucin-type.
    Biol. Chem 382, 143-149

  69. Beatty, P., Hanisch, F.-G., Beer Stolz, D., Finn, O.J., Ciborowski, P. (2001)
    Biochemical characterization of the soluble form of tumor antigen MUC1 isolated from sera and ascites fluid of breast and pancreatic cancer patients.
    Clinical Cancer Research 7 (3 Suppl), 781-787

  70. Hanisch, F.-G., Jovanovic, M., Peter-Katalinic, J. (2001)
    Glycoprotein identification and localization of O-glycosylation sites by mass spectrometric analysis of deglycosylated / alkylaminylated peptide fragments.
    Anal. Biochem. 290, 47-59

  71. Baldus, S.E., Zirbes, T.K., Hanisch, F.-G., Kunze, D., Shafizadeh,S.T.,Nolden, S., Monig, S.P., Schneider, P.M., Karsten, U., Thiele, J., Holscher, A.H., Dienes, H.P. (2000)
    Thomsen-Friedenreich antigen presents as a prognostic factor in colorectal carcinoma: A clinicopathological study of 264 patients.
    Cancer 88, 1536-1543

  72. Baldus, S.E., Zirbes, T.K., Weingarten, M., Fromm, S., Glossmann, J., Hanisch, F.-G., Monig, S.P., Schröder, W., Flucke, U., Thiele, J., Holscher, A.H., Dienes, H.P. (2000)
    Increased galectin-3 expression in gastric cancer: correlations with histopathological subtypes, galactosylated antigens and tumor cell proliferation.
    Tumor Biol. 21, 258-266

  73. Baldus, S.E., and Hanisch, F.-G. (2000)
    Biochemistry and pathological importance of mucin-associated antigens in gastrointestinal neoplasia.
    Adv. Cancer Res 79, 201-248

  74. Hanisch, F.-G. and Müller, S. (2000)
    MUC1: The polymorphic appearence of a human mucin.
    Glycobiology 10, 439-449

  75. Müthing, J., Duvar, S., Heitmann, D., Hanisch, F.-G., Neumann, U., Lochnit, G., Geyer, R., Peter-Katalinic, J. (1999)
    Isolation and structural characterization of glycosphingolipids of in vitro propagated human umbilical vein endothelial cells.
    Glycobiology 9, 459-468

  76. Müller, S., Alving, K., Peter-Katalinic, J., Zachara, N., Gooley, A.A., Hanisch, F.-G. (1999)
    High density O-glycosylation on tandem repeat peptide from secretory MUC1 of T47D breast cancer cells.
    J. Biol. Chem 274, 18165-18172

  77. Schroten, H., Bosch, M., Nobis-Bosch, R., Köhler, H., Hanisch, F.-G., Plogmann, R. (1999)
    Secretory immunoglobulin A is a component of the human milk fat globule membrane.
    Ped. Res. 45, 82-86

  78. Hanisch, F.-G., Müller, S., Hassan, H., Clausen, H., Zachara, N., Gooley, A.A., Paulsen, H., Alving, K., Peter-Katalinic, J. (1998)
    Dynamic epigenetic regulation of initial O-glycosylation by UDP-GalNAc: peptide N-acetylgalactosaminyltransferases: site-specific glycosylation of MUC1 repeat peptide influences the substrate qualities at adjacent or distant Ser/Thr positions.
    J. Biol. Chem. 274, 9946-9954

  79. Schroten, H., Stapper, C., Plogmann, R., Koehler, H., Hacker, J., Hanisch, F.-G. (1998)
    Fab-independent anti-adhesion effects of s-IgA on S-fimbriated E.coli are mediated by sialylologosaccharides.
    Infect. Immun 66, 3971-3973

  80. Baldus, S.E., Zirbes, T.K., Engel, S., Hanisch, F.-G., Mönig, S.P., Lorenzen, J., Glossmann, J., Fromm, S., Thiele, J., Pichlmaier, H., Dienes, H.P. (1998)
    Correlation of the immunohistochemical reactivity of mucin peptide cores MUC1 and MUC2 with the histopathological subtype and prognosis of gastric carcinomas.
    Int. J. Cancer 79, 133-138

  81. Hanisch, F.-G., Green, B.N., Bateman, R., Peter-Katalinic, J. (1998)
    Localization of O-glycosylation sites of MUC1 tandem repeats by QTOF ESI mass spectrometry.
    J. Mass Spectrom. 33, 358-362

  82. Karsten, U., Diotel, C., Klich, G., Paulsen, H., Goletz, S., Müller, S., Hanisch, F.-G. (1998)
    Enhanced binding of antibodies to the DTR motif of MUC1 tandem repeat peptide is mediated by site-specific glycosylation.
    Cancer Res. 58, 2541-2549

  83. Hanisch, F.-G. (1998)
    Specificity clusters of MUC1-reactive mouse monoclonal antibodies.
    Tumor Biol. 19, 111-117

  84. Baldus, S.E., Hanisch, F.-G., Kotlarek, G.M., Zirbes, T.L., Thiele, J., Isenberg, J., Karsten, U.R., Devine, P.L., Dienes, H.P. (1998)
    Co-expression of MUC1 peptide core and Thomsen-Friedenreich (TF) antigens in colorectal neoplasms.
    Cancer 82, 1019-1027

  85. Duvar, S., Peter-Katalinic, J., Hanisch, F.-G., Müthing, J. (1997)
    Isolation and structural characterization of glycosphingolipids of in vitro propagated bovine aortic endothelial cells.
    Glycobiology 7, 1099-1109

  86. Müller, S., Goletz, S., Packer, N., Gooley, A.A., Lawson, A.M., Hanisch, F.-G. (1997)
    Localisation of O-glycosylation sites on glycopeptide fragments from lactation-associated MUC1: All putative sites within the tandem repeat are glycosylation targets in vivo
    J. Biol. Chem. 272, 24780-24793

  87. Goletz, S., Hanisch, F.-G., Karsten, U. (1997)
    A novel posttranslational modification of intermediate filaments: GalNAc containing glycans on cytokeratins, a putative cytoplasmic ligand for galectins.
    J. Cell Sci 110, 1585-1596

  88. Goletz, S., Thiede, B., Hanisch, F.-G., Müller, S., Peter-Katalinic, J., Schultz, M., Seitz, O., Karsten, U. (1997)
    A sequencing strategy for the localization of O-glycosylation sites of MUC1 tandem repeats by PSD-MALDI mass spectrometry.
    Glycobiology 7, 881-896

  89. Hanisch, F.-G., Baldus, S.E. (1996)
    The Thomsen-Friedenreich antigen. A critical review.
    Histol. Histopathol. 12, 263-281

  90. Baldus, S.E., Thiele, J., Park, Y.O., Hanisch, F.-G., Bara, J., Fischer, R.(1996)
    Characterization of the binding specificity of Anguilla Anguilla Agglutinin (AAA) in comparison to other fucose-specific lectins.
    Glycoconjugate J. 13, 585-590

  91. Müthing, J., Spanbroek, R., Peter-Katalinic, J., Hanisch, F.-G., Hanski, C., Hasegawa, A., Unland, F., Lehmann, J., Tschesche, H., Egge, H. (1996)
    Isolation and structural characterization of fucosylated gangliosides with linear poly-N-acetyllactosaminyl chains from human granulocytes.
    Glycobiology 6, 147-156

  92. Spencer, D.I.R., Price, M.R., Tendler, S.J.B., Dematteis, C.J., Stadie, T., Hanisch, F.-G., (1996)
    Effect of glycosylation of a synthetic MUC1 mucin core-related peptide on recognition by anti-mucin antibodies.
    Cancer Lett. 100, 11-15

  93. Hanisch, F.-G., Baldus, S.E., Kümmel, T. (1996)
    Forssman disaccharide is the specific ligand of a galectin from the sponge Geodia cydonium, but does not mediate its binding to nuclear protein np56.
    Glycobiology 6, 321-336

  94. Baldus, S.E., Vierbuchen, M., Hanisch, F.-G., Schwonzen, M., Fischer, R. (1995)
    Expression of (3/4-monofucosylated polylactosaminoglycan epitope, as defined by monoclonal antibody FW6, is a marker of the colorectal adenoma-carcinoma sequence.
    Cancer 76, 954-960

  95. Baldus, S.E., Thiele, J., Park, Y.O., Charles, A., Mross, C., Hanisch, F.-G., Zirbes, T.K., Wickenhauser, C., Fischer, R. (1995)
    Carbohydrate and peptide antigens in macrophage populations derived from human bone marrow and milk. An immunomorphological and immunochemical analysis.
    Histochem.J. 27, 630-638

  96. Hanisch, F.-G., Stadie, T., Deutzmann, F., Peter-Katalinic, J. (1995)
    MUC1 glycoforms in breast cancer: cell line T47D as a model for cancer-associated alterations of O-glycosylation.
    Eur. J., Biochem. 236, 318-327

  97. Hanisch, F.-G., Stadie, T., Boßlet, K. (1995)
    Monoclonal antibody BW835 defines a site-specific Thomsen-Friedenreich disaccharide linked to threonine within the VTSA motif of MUC1 tandem repeats.
    Cancer Res., 55, 4036-4040

  98. Stadie, T., Chai, W., Lawson, A.M., Byfield, P., Hanisch, F.-G. (1995)
    Studies on the order and site specificity of GalNAc-transfer to MUC1 tandem repeats by UDP-GalNAc: polypeptide N-acetylgalactosaminyl transferase from milk or mammary carcinoma cells.
    Eur. J. Biochem. 229, 140-147

  99. Karsten U., Butschak, G., Cao, Y., Goletz, S., Hanisch, F.-G. (1995)
    A new monoclonal antibody (A78-G/A7) to the Thomsen-Friedenreich pan-tumor antigen.
    Hybridoma 14, 37-44

  100. Baldus, S.E., Thiele, J., Charles, A., Hanisch, F.-G., Fischer, R. (1994)
    Carbohydrate antigens of human megakaryocytes and platelet glycoproteins: a comparative study.
    Histochemistry 102, 205-211

  101. Peter-Katalinic, Ashcroft, A., Green, B., Hanisch, F.-G., Nakahara, Y., Iliima, H., Ogawa, T. (1994)
    Potential of electrospray mass spectrometry for structural studies of O-glycoamino acids and -peptides with multiple (2,6-sialosyl-Tn glycosylation.
    Org. Mass Spectrom. 29, 747-752

  102. Schroten, H., Plogmann, R., Nobis-Bosch, R., Hanisch, F.-G., Hacker, J., Wahn, V. (1994)
    Hemmung der bakteriellen Adhärenz durch Muttermilchmucine.
    Pädiatr. Grenzgeb. 32, 471-477

  103. Müthing, J., Peter-Katalinic, J., Hanisch, F.-G., Unland, F., Lehmann, J. (1994)
    The ganglioside GD1(, IV3NeuAc, III6NeuAc-GgOse4Cer, is a major disialogangliodies in the highly metastatic murine lymphoreticular tumor cell line MDAY-D2.
    Glycoconjugate J. 11, 153-162

  104. Peter-Katalinic, J., Williger, K., Egge, H., Green, B., Hanisch, F.-G., Schindler, D. (1994)
    The application of electrospray mass spectrometry for structural studies on a tetrasaccharide monopeptide from the urine of a patient with alpha-N-acetylhexosaminidase deficiency.
    J. Carbohydr. Chem. 13, 447-456

  105. Hanisch, F.-G. (1994)
    Methylation analysis of complex carbohydrates: Overview and critical comments.
    Biol. Mass Spectrom., 23, 309-312

  106. Hanski, C., Drechsler, K., Hanisch, F.-G., Sheehan, J., Manske, M., Ogorek, D., Klussmann, E., Hanski, M.-L., Blank, M., Xing, P.-X., McKenzie, I.F.C., Devine, P.L., Riecken, E.O. (1993)
    Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewisx expression.
    Cancer Res. 53, 4082-4088

  107. Hanisch, F.-G., Auerbach B., Bosslet, K., Kolbe, K., Kasten, U., Nakahara, Y., Ogawa, T., Uhlenbruck, G. (1993)
    Monoclonal antibody BW494 defines a blood group Lewisa/type 1 chain-related antigen on carcinoma-associated mucins.
    Biol. Chem. Hoppe-Seyler 343, 1083-1091

  108. Hanisch F.-G., Koldovsky U., Borchard F. (1993)
    Monoclonal antibody 2B5 defines a truncated O-glycan, GlcNAcß1-3Galß1-4GlcNAcß1-6(GalNAc), on mucins from deep gastric and duodenal glands as well as metaplasia and neoplasia of gastric differentiation.
    Cancer Res. 53, 4791-4796

  109. Hanisch F.-G., Chai W., Rosankiewicz J.R., Lawson A.M., Stoll M.S., Feizi T. (1993)
    Core-typing of O-linked glycans from human gastric mucins: Lack of evidence for the occurrence of the core sequence Gal1-6GalNAc.
    Eur. J. Biochem. 217, 645-655

  110. Hanisch F.-G., Heimbüchel G., Baldus, S.E., Uhlenbruck, G., Schmits, R., Pfreundschuh, M., Schwonzen, M., Vierbuchen, M., Bara, J., Peter-Katalinic, J. (1993)
    Monoclonal Antibody FW6 defines an epitope on (3/4-monofucosylated polylactosamino-glycans expressed by fetal and colon carcinoma-associated mucins.
    Cancer Research 53, 4367-4375

  111. Hanisch, F.-G., Hacker, J., Schroten H. (1993)
    Specificity of S-fimbriae on recombinant Escherichia coli: Preferential binding to gangliosides expressing NeuGc((2-3)Gal and NeuAc((2-8)NeuAc.
    Infection and Immunity 61, 2108-2115

  112. Müthing J., Unland, F., Heitmann, D., Orlich, M., Hanisch, F.-G., Peter-Katalinic, J., Knäuper V., Tschesche, H., Kelm S., Schauer, R., and Lehmann J. (1993)
    Different binding capacities of influenza A and Sendai virus to gangliosides from human granulocytes.
    Glycoconjugate Journal 10, 120-126

  113. Schroten, H., Plogmann, R., Hanisch, F.-G., Hacker, J., Nobis-Bosch, R., and Wahn, V. (1993)
    Inhibition of adhesion of S-fimbriated E. coli to buccal epithelial cells by human skim milk is predominantly mediated by mucins and depends on the period of lactation.
    Acta Paediatr. 82, 6-11

  114. Vierbuchen, M., Larena, A., Schröder, S., Hanisch, F.-G., Ortmann, M., Uhlenbruck, G., Fischer, R. (1992)
    Blood group antigen expression in medullary carcinoma of the thyroid. An immunohistochemical study on the occurrence of type1 chain-derived antigens.
    Virchows Arch. B Cell Pathol Incl. Mol. Pathol. 62, 79-88

  115. Pfeifer, K., Schröder, H.C., Rinkevich, B., Uhlenbruck, G., Hanisch, F.-G., Kurelec, B., Scholz, P., Müller, W.E.G. (1992)
    Immunological and biological identification of tumor necrosis-like factor in sponges: endotoxin that mediates necrosis formation in xenografts.
    Cytokine 4, 161 -169

  116. Dreßen, F., Hanisch, F.-G., Uhlenbruck, G. (1992)
    A quantitative microassay of carbohydrate-mediated cell adhesion to glycoconjugates immobilized on polystyrene plates.
    Analytical Biochemistry 206, 369-375

  117. Muralikrishna G., Reuter, G., Peter-Katalinic, J., Egge, H., Hanisch, F.-G. Siebert, H.-C., and Schauer R. (1992)
    Identification of a new ganglioside from the starfish Asterias rubens.
    Carbohydrate Research 236, 321-326

  118. Hanski, C., Hanisch, F.-G., Riecken, E.O. (1992)
    Alteration of mucin-bound carbohydrate moieties in malignant transformation of colonic mucosa.
    The Cancer Journal 5, 332-342 (Übersichtsartikel)

  119. Baldus, S.E., Hanisch, F.-G., Schwonzen, M., Nakahara, Y., Iijima, H., Ogawa, T., Peter-Katalinic, J., and Uhlenbruck, G. (1992)
    Monoclonal antibody SP-21 defines a sialosyl-Tn antigen expressed on carcinomas and K562 erythroleukemia cells.
    Anticancer Research 12, 1935-1940

  120. Schroten, H., Lethen, A., Hanisch, F.-G., Plogmann, R., Hacker, J., Nobis-Bosch, R., and Wahn, V. (1992)
    Inhibition of adhesion of S-fibriated Escherichia coli to epithelial cells by meconium and feces of breast-fed and formula-fed newborns: Mucins are the major inhibitory component. J. Pediatric Gastroenterology and Nutrition 15, 150-158
  121. Schroten, H., Steinig, M., Plogmann, R., Hanisch, F.-G., Hacker, J., Herzig, P., Wahn, V. (1992)
    S-fimbriae mediated adhesion of Escherichia coli to human buccal epithelial cells is age independent.
    Infection 20, 273-275

  122. Hanisch, F.-G., Hanski, C., Hasegawa, A. (1992)
    Sialyl Lewis x antigen as defined by monoclonal antibody AM-3 is a marker of dysplasia in the colonic adenoma-carcinoma sequence.
    Cancer Res. 52, 3138-3144

  123. Schroten, H., Hanisch, F.-G., Plogmann, R., Hacker, J., Uhlenbruck, G., Nobis-Bosch R., Wahn, V. (1992)
    Inhibition of adhesion of S-fimbriated E. coli to buccal epithelial cells by human milk fat globule membrane components: A novel aspect of protective function of mucins in the non-immunoglobulin fraction.
    Infect. Immun., 60, 2893-2899

  124. Schwonzen, M., Schmits, R., Baldus, S.E., Vierbuchen, M., Hanisch, F.-G., Pfreundschuh, M., Diehl, V., Bara, J., Uhlenbruck, G. (1992)
    Monoclonal antibody FW6 generated against a mucin-carbohydrate of human amniotic fluid recognises a colonic tumour-associated epitope.
    Br. J. Cancer 62, 559-565

  125. Hanisch, F.-G., Peter-Katalinic, J. (1992)
    Structural studies on fetal mucins from human amniotic fluid. Core typing of short-chain O-linked glycans.
    Eur. J. Biochem. 205, 527-535

  126. Uhlenbruck, G., Hanisch, F.-G., Kljajic, Z., Poznanovic, S., Schröder, H.C., Müller, W.E.G. (1992)
    The lectin from the algae Udotea petiolata: Isolation, characterization and sugar binding properties.
    Behring Inst. Mitt. 91, 67-77

  127. Vierbuchen, M., Uhlenbruck, G., Hanisch, F.-G., Müller, W.E.G., Ortmann, M., Fischer, R. (1991)
    Histochemical Reactivity of the Geodia cydonium agglutinin (GCA) in human tissues.
    J. Histochem. Cytochem. 39, 491-505

  128. Schroten, H., Wolske, A., Plogmann, R., Hanisch, F.-G., Hacker, J., Uhlenbruck, G. Wahn, V. (1991)
    Binding of cloned S-fimbriated E. coli to human buccal epithelial cells - Different inhibition of binding by neonatal saliva and adult saliva.
    Zbl. Bakt. 274, 514-518

  129. Müthing, J., Peter-Katalinic, J., Hanisch, F.-G., Neumann, U. (1991)
    Structural studies of gangliosides from the YAC-1 mouse lymphoma cell line by immunological detection and fast atom bombardment mass spectrometry.
    Glycoconjugate J. 8, 414-423

  130. Hanisch, F.-G., Sölter, J., Jansen, V., Lochner, A., Peter-Katalinic, J., Uhlenbruck, G. (1990)
    Glycosphingolipid expression on murine L1-fibrosarcoma cells: analysis of clonal in vivo and in vitro selected sublines with different lung colonisation potetial.
    Br. J. Cancer 61, 813-820

  131. Hanisch, F.-G., Peter-Katalinic, J., Egge, H., Dabrowski, U., Uhlenbruck, G. (1990)
    Structures of acidic O-linked polylactosamino glycans on human skim milk mucins.
    Glycoconjugate J. 7, 525-543

  132. Lochner, A., Hanisch, F.-G., Uhlenbruck, G. (1990)
    Carbohydrate-mediated cell adhesion to glycoproteins immobilized on nitrocellulose.
    Anal. Biochem. 190, 108-115

  133. Hanisch, F.-G., Uhlenbruck, G., Peter-Katalinic, J., Egge, H., Dabrowski, J., Dabrowski, U.(1989)
    Structures of neutral O-linked polylactosaminoglycans on human skim milk mucins: A novel type of linearly extended poly-N-acetyllactosamine backbones with Galß(1-4) GlcNAcß(1-6) repeating units.
    J. Biol. Chem. 264, 872-883

  134. Hanisch, F.-G., Uhlenbruck, G., Egge, H., Peter-Katalinic, J. (1989)
    A B72.3 second-generation-monoclonal antibody (CC49) defines the mucin-carried carbohydrate epitope Galß(1-3)[NeuAcÂ(2-6)]GalNAc.
    Biol. Chem., Hoppe-Seyler 370, 21-26

  135. Mitsakos, A., Hanisch, F.-G. (1989)
    A one step purification on fetuin-agarose of Â3-fucosyltransferase from human amniotic fluid.v Biol. Chem. Hoppe-Seyler 370, 239-243

  136. Karsten, U., Pilgrim, G., Hanisch, F.-G., Uhlenbruck, G., Kasper, M., Stosiek, P., Papsdorf, G. Pasternak, G. (1988)
    A new monoclonal antibody (A46-B/B10) highly specific for the blood group H type 2 epitope: Generation, epitope analysis, serological and histological evaluation.
    Br. J. Cancer 58, 176-181

  137. Mitsakos, A., Hanisch, F.-G., Uhlenbruck, G. (1988)
    Biosynthesis of the cancer-associated sialyl Lex-determinant in human amniotic fluid.
    Biol. Chem. Hoppe-Seyler 369, 661-665

  138. Hanisch, F.-G., Uhlenbruck, G., Peter-Katalinic, J. Egge, H., (1988)
    Structural studies on oncofetal carbohydrate antigens (Ca19-9, Ca50 and Ca125) carried by O-linked sialyl-oligosaccharides on human amniotic mucins.
    Carbohydr. Res. 178, 29-47

  139. Hanisch, F.-G., Mitsakos, A., Schroten, H., Uhlenbruck, G. (1988)
    Biosynthesis of cancer-associated sialyl-Lex antigen by an (-3-L-fucosyltransferase of human amniotic fluid.
    Carbohydr. Res. 178, 23-28

  140. Schroten, H., Uhlenbruck, G. Hanisch, F.-G., van Mil, A. (1987)
    Unterschiedliche Phagozytoserate menschlicher Blutmonozyten und Muttermilchmakrophagen: Einfluß von Intralipid und Milchfettkügelchen.
    Monatschr. Kinderheilk. 135, 36-40

  141. Hanisch, F.-G., Egge, H., Peter-Katalinic, J., Uhlenbruck, G. (1986)
    Primary structure of a major sialyl-saccharide alditol from human amniotic mucins expressing the tumor-associated sialyl-Lex antigenic determinant.
    FEBS-Lett. 200, 42-46

  142. Hanisch, F.-G., Egge, H., Peter-Katalinic, J., Uhlenbruck, G. (1986)
    Structure of neutral oligosaccharides derived from mucus glycoproteins of human seminal plasma.
    Eur. J. Biochem. 155, 239-247

  143. Hanisch, F.-G., Egge, H., Peter-Katalinic, J., Uhlenbruck, G., Dienst, C., Fangmann, R. (1985)
    Primary structures and Lewis blood-group-dependent expression of major sialylated saccharides from mucus glycoproteins of human seminal plasma.
    Eur. J. Biochem. 152, 343-351

  144. Hanisch, F.-G., Uhlenbruck, G., Dienst, C., Stottrop, M., Hippauf, E. (1985)
    Ca 125 and Ca 19-9: two cancer-associated sialylsaccharide antigens on a mucus glycoprotein from human milk.
    Eur. J. Biochem. 149, 323-330

  145. Uhlenbruck, G., van Meensel-Maene, U., Hanisch, F.-G., Dienst, C. (1984)
    Unexpected occurrence of the Ca19-9 marker in normal human seminal plasma.
    Hoppe-Seyler's Z. Physiol. Chem. 365, 613-617

  146. Hanisch, F.-G., Uhlenbruck, G., Dienst, C. (1984)
    Structure of tumor-associated carbohydrate antigen Ca19-9 on human seminal plasma glycoproteins from healthy donors.
    Eur. J. Biochem. 144, 467-474

  147. Fischer, J., Klein, P.J., Farrar, G.H., Hanisch, F.-G., Uhlenbruck, G. (1984)
    Isolation and chemical and immunochemical characterization of the peanut-lectin-binding glycoprotein from human milk-fat globule membranes.
    Biochem. J. 224, 518-589

  148. Hanisch, F.-G., Saur, A., Müller W.E.G., Conrad, J., Uhlenbruck, G. (1984)
    Further characterization of a lectin and its in vitro receptor from Geodia cydonium.
    Biochim. Biophys. Acta 801, 388-395

  149. Hanisch, F.-G., Uhlenbruck, G. (1984)
    Structural studies on O- and N- glycosidically linked carbohydrate chains on Collocalia mucin.
    Hoppe-Seyler's Z. Physiol. Chem 365, 119-128

  150. Hanisch, F.-G., Farrar, G.H., Schmalisch, R., Uhlenbruck, G. (1983)
    Immunochemistry of O-glycosidically-linked Galß(1-3)GalNAc on fragments of human glycophorin A.
    Immunobiol. 165, 147-160


25 Juli 2013
Franz-Georg Hanisch
Institut für Biochemie II, Joseph-Stelzmann-Strasse 52, D50931 Köln
Anregungen und Wünsche: Budi Tunggal
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