Mörsdorf group  
Publications


  1. Thier K, Möckel M, Palitzsch K, Döhner K, Sodeik B, Knebel-Mörsdorf D. 2018.
    Entry of herpes simplex virus 1 into epidermis and dermal fibroblasts is independent of the scavenger receptor MARCO.
    J. Virol. 92, e00490-18

  2. Thier K, Petermann P, Rahn E, Rothamel D, Bloch W, Knebel-Mörsdorf D. 2017.
    Mechanical barriers restrict invasion of herpes simplex virus 1 into human oral mucosa.
    J. Virol. 91, e01295-17

  3. Rahn E, Thier K, Petermann P, Röbsam M, Staeheli P, Iden S, Niessen CM, and Knebel-Mörsdorf D. 2017.
    Epithelial barriers in murine skin during herpes simplex virus 1 infection: The role of tight junction formation.
    J. Invest. Dermatol. 137, 884-893

  4. Knebel-Mörsdorf, D. 2016.
    Nectin-1 and HVEM: cellular receptors for HSV-1 in skin.
    Oncotarget, DOI: 10.18632/oncotarget.8340

  5. Petermann P, Rahn E, Thier K, Hsu MJ, Rixon FJ, Kopp SJ, and Knebel-Mörsdorf D. 2015.
    Role of nectin-1 and HVEM as cellular receptors for herpes simplex virus 1 on primary murine dermal fibroblasts.
    J. Virol. 89, 9407-9416

  6. Rahn E, Petermann P, Thier K, Bloch W, Morgner J, Wickström SA, and Knebel-Mörsdorf D. 2015.
    Invasion of herpes simplex virus type 1 into murine epidermis: an ex vivo infection study.
    J. Invest. Dermatol. 135, 3009-3016

  7. Rahn E, Thier K, Petermann P, and Knebel-Mörsdorf D. 2015.
    Ex vivo infection of murine epidermis with herpes simplex virus type 1.
    J. Vis. Exp., e53046

  8. Petermann, P., Thier, K., Rahn, E., Rixon, F.J., Bloch, W., Özcelik, S., Krummenacher, C., Barron, M.J., Dixon, M.J., Scheu, S., Pfeffer, K. and Knebel-Mörsdorf, D. 2015.
    Entry mechanisms of Herpes Simplex Virus Type 1 into murine epidermis: Involvement of nectin-1 and HVEM as cellular receptors.
    J. Virol. 89, 262-274.

  9. Mainz, D., Quadt, I., Stranzenbach, A. K., Voss, D., Guarino, L. A., and Knebel-Mörsdorf, D. 2014.
    Expression and nuclear localization of the TATA-box-binding protein during baculovirus infection.
    J. gen Virol. 95, 1396-1407

  10. Rahn, E., Petermann, P., Hsu, M.-J., Rixon, F.J., and Knebel-Mörsdorf, D. 2011.
    Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.
    PLoS ONE 6 (10):e25464. doi:10. 1371/journal. pone. 0025464

  11. Jaeger, V., Hoppe, S., Petermann, P., Liebig, T., Jansen, M. K., Renné, T., and Knebel-Mörsdorf, D. 2010.
    Herpes simplex virus type 1 entry into epithelial MDCKII cells: Role of VASP activities.
    J. gen Virol. 91, 2152-2157

  12. Petermann, P., Haase, I. and Knebel-Mörsdorf, D. 2009
    Impact of Rac1 and Cdc42 signaling during early Herpes simplex virus type 1 infection of keratinocytes.
    J. Virol. 83, 9759-9772

  13. Quadt, I., van Lent, J. W. M., and Knebel-Mörsdorf, D. 2007
    Studies of the silencing of baculovirus DNA binding protein.
    J. Virol. 81, 6122-6127

  14. Hoppe, S., Schelhaas, M., Jaeger, V., Liebig, T., Petermann, P., and Knebel-Mörsdorf, D. 2006
    Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells.
    J. gen Virol. 87, 3483-3494

  15. Knebel-Mörsdorf, D., Quadt, I., Yi, L., Montier, L., and Guarino, L. 2006
    Expression of baculovirus late and very late genes depends on lef-4, a component of the viral RNA polymerase whose guanyltransferase function is essential.
    J. Virol. 80, 4168-4173

  16. Quadt, I., Günther, A. K., Voß, D., Schelhaas, M., and Knebel-Mörsdorf, D. 2006
    TATA-binding protein and TBP-associated factors during herpes simplex virus type 1 infection: Localization at viral DNA replication sites.
    Virus Res. 115, 207-213

  17. Schelhaas, M., Jansen, M., Haase, I., and Knebel-Mörsdorf, D. 2003
    Herpes simplex virus type 1 exhibits a tropism for basal entry in polarized epithelial cells.
    J. gen Virol. 84, 2473-2484

  18. Quadt, I., Mainz, D., Mans, R. M., Kremer, A., and Knebel-Mörsdorf, D. 2002
    Baculovirus infection raises the level of TATA-binding protein that colocalizes with viral DNA replication sites.
    J. Virol.76, 11123-11127

  19. Mainz, D., Quadt, I., and Knebel-Mörsdorf, D. 2002
    Nuclear IE2 structures are related to viral DNA replication sites during baculovirus infection.
    J. Virol., 76, 5198-5207

  20. Murges, D., Quadt, I., Schröer, J., and Knebel-Mörsdorf, D. 2001
    Dynamic nuclear localization of the baculovirus proteins IE2 and PE38 during the infection cycle: The promyelocytic leukemia protein colocalizes with IE2.
    Exp. Cell Res. 264, 219-232.

  21. Dreschers, S., Roncarati, R., and Knebel-Mörsdorf, D. 2001
    The actin rearrangement inducing factor of baculoviruses is tyrosine-phosphorylated and colocalizes to F-actin at the plasma membrane.
    J. Virol., 75, 3771-3778.

  22. Mans, R. M. W., and Knebel-Mörsdorf, D. 1999
    Mitochondrial DNA acts as a potential promoter of the baculovirus-induced RNA polymerase.
    Biological Chemistry, 380, 579-583

  23. Knebel-Mörsdorf, D., Kremer, A., Roncarati, R., Murges, D., Dreschers, S., and Quadt, I. 1999
    The role of early virus genes during the AcMNPV infection cycle.
    RIKEN review, Vol. 22:22-25

  24. Mans, R. M. W., and Knebel-Mörsdorf, D.1998
    In vitro transcription of pe38/polyhedrin hybrid promoters reveals sequences essential for recognition by the baculovirus-induced RNA polymerase and for the strength of very late promoters.
    J. Virol., 72:2991-2998

  25. Kremer, A., and Knebel-Mörsdorf, D. 1998
    The early baculovirus he65 promoter: On the mechanism of transcriptional activation by IE1.
    Virology, 249:336-351

  26. Roncarati, R., and Knebel-Mörsdorf, D. 1997
    Identification of the early actin rearrangement inducing factor, arif-1, from Autographa californica multicapsid nuclear polyhedrosis virus.
    J. Virol. 71, 7933-7941

  27. Murges, D., Kremer, A., and Knebel-Mörsdorf, D. 1997
    Baculovirus transactivator IE1 is functional in mammalian cells.
    J. gen. Virol. 78, 1507-1510

  28. Knebel-Mörsdorf, D. , Flipsen, J.T.M., Roncarati, R., Jahnel, F., Kleefsman, A.W.F., and Vlak, J.M. 1996
    Baculovirus infection of Spodoptera exigua larvae: LacZ expression driven by promoters of early genes pe38 and me53 in larval tissue.
    J. gen. Virol. 77, 815-824
  29. Krappa, R., Roncarati, R., and Knebel-Mörsdorf, D. 1995
    Expression of PE38 and IE2, viral members of the C3HC4 finger family, during baculovirus infection: PE38 and IE2 localize to distinct nuclear regions.
    J.Virol. 69, 5287-5293

  30. Flipsen, J.T.M., Mans, R.M.W., Knebel-Mörsdorf, D., Kleefsman, A.W.F., and Vlak, J.M. 1995
    Deletion of the baculoviral ecdysteroid UDP-glucosyltransferase gene induces early degeneration of malpighian tubules in infected insects.
    J. Virol. 69, 4529-4532

  31. Knebel-Mörsdorf, D. , Kremer, A., and Jahnel, F. 1993
    Baculovirus gene ME53, which contains a putative zinc finger motif, is one of the major early-transcribed genes.
    J. Virol. 67, 753-758.

  32. Becker, D., and Knebel-Mörsdorf, D. 1993
    Sequence and temporal appearance of the early transcribed baculovirus gene HE65.
    J. Virol. 67, 5867- 5872.

  33. Krappa, R., and Knebel-Mörsdorf, D. 1993
    Transcriptional control of early baculovirus genes.
    In: Virus Strategies. W. Doerfler, P. BMöhm (eds.) Verlag Chemie, Weinheim, pp. 335-345.

  34. Krappa, R., Behn-Krappa, A., Jahnel, F., Doerfler, W., and Knebel-Mörsdorf, D. 1992
    Differential factor binding at the promoter of early baculovirus gene PE38 during viral infection: GATA motif is recognized by an insect protein.
    J. Virol 66, 3494-3505.

  35. Krappa R., and Knebel-Mörsdorf, D. 1991
    Identification of the very early transcribed baculovirus gene PE38.
    J. Virol. 65, 805-812.

  36. Li, J., Happ, B., Schetter, C., Oellig, C., Hauser, C., Kuroda, K., Knebel-Mörsdorf, D., Klenk, H.-D., and Doerfler, W. 1990
    The expression of the Autographa californica nuclear polyhedrosis virus genome in insect cells. Veterinary Microbiology 23, 73-78.

  37. Doerfler, W., Hoeveler, A., Weisshaar, B., Dobrzanski, P., Knebel, D., Langner, K.-D., Achten, S., and Müller, U. 1989
    Promoter inactivation by sequence-specific methylation and mechanisms of reactivation.
    Cell Biophysics 15, 21- 27.

  38. Knebel-Mörsdorf, D., Achten, S., Langner, K.-D., Rüger, R., Fleckenstein, B., and Doerfler, W. 1988
    Reactivation of the methylation-inhibited late E2A promoter of adenovirus type 2 by a strong enhancer of human cytomegalovirus.
    Virology 166, 166-174.

  39. Doerfler, W., Weisshaar, B., Hoeveler, A., Knebel, D., Dobrzanski, P., Knust, B., Achten, S., and Hermann, R. 1988
    Promoter inhibition by DNA methylation: a reversible signal.
    Gene 74, 129-133.

  40. Doerfler, W., Langner, K.-D., Knebel, D., Müller, U., Lichtenberg, U., Weisshaar, B., and Renz, D. 1988
    Eukaryotic gene inactivation by sequence-specific promoter methylation and the release of the transcription block.
    In: Architecture of Eukaryotic Genes. G. Kahl (ed.) Verlag Chemie, Weinheim, pp. 409- 417.

  41. Knebel, D., and Doerfler, W. 1987
    Activation of an insect baculovirus promoter in mammalian cells by adenovirus functions.
    Virus Res. 8, 317-326.

  42. Knebel, D., Langner, K.-D., Hoeveler, A., Lichtenberg, U., Renz, D., and Doerfler, W. 1987
    Sequence-specific DNA methylation: promoter inactivation and release of the expression block.
    In: Tumor Cell Differentiation. Biology and Pharmacology. J. Aarbakke, P.K. Chiang, H.P. Koeffler (eds.) Humana Press, Clifton, N.J., pp. 215-230.

  43. Knebel, D., and Doerfler, W. 1986
    N6-methyldeoxyadenosine residues at specific sites decrease the activity of the E1A promoter of adenovirus type 12 DNA.
    J. Mol. Biol. 189, 371-375.

  44. Doerfler, W., Langner, K.-D., Knebel, D., Lübbert, H., and Knust-Kron, B. 1986
    Inactivation of viral promoters by in vitro methylation. Studies on the adenovirus and baculovirus system.
    Developments in Molecular Virology 8, 193-222.

  45. Doerfler, W., Langner, K.-D., Knebel, D., and Weyer, U. 1986
    Regulation of gene expression by site-specific promoter methylations.
    In: Biological Methylation and Drug Design. R.T. Borchardt, C.R. Creveling, P.M. Ueland (eds.) The Humana Press, Inc., Clifton, N.J., pp. 139- 150.

  46. Knebel, D., Lübbert, H., and Doerfler, W. 1985
    The promoter of the late p10 gene in the insect nuclear polyhedrosis virus Autographa californica: activation by viral gene products and sensitivity to DNA methylation.
    EMBO J. 4, 1301-1306.

  47. Doerfler, W., Langner, K.-D., Knebel, D., Lübbert, H., Kruczek, I., and Weyer, U. 1985
    Site-specific methylations inactivate viral promoters.
    In: Hormones and Cell Regulation. Vol. 9. J.E. Dumont, B. Hamprecht, J. Nunez (eds.) Elsevier Science Publishers, Amsterdam, pp. 47-67.

  48. Doerfler, W., Langner, K.-D., Knebel, D., Weyer, U., Dobrzanski, P., and Knust-Kron, B. 1985
    Site-specific promoter methylations and gene inactivation.
    In: Biochemistry and Biology of DNA Methylation. G.L. Cantoni, A. Razin (eds.) Alan R. Liss, Inc., New York, pp. 133-155.


June 20, 2018
Dagmar Mörsdorf
Institute for Biochemistry II, Joseph-Stelzmann-Strasse 52, D50931 Cologne
Suggestions and wishes: Gudrun Konertz
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