Sengle group  

Bookchapters and Reviews
  1. Troilo, H., Barrett, A.L., Wohl, A.P., Jowitt, T.A., Collins, R.F., Bayley, C.P., Zuk, A.V., Sengle, G., and Baldock, C. The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity. Biochem. Soc. Trans. 43, 795-800 (2015)
  2. Sengle, G., and Sakai, L.Y. The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation? Matrix Biol. 47, 3-12 (2015)
  3. Eckes, B., Moinzadeh, P., Sengle, G., Hunzelmann, N., and Krieg, T. Molecular and cellular basis of scleroderma. J. Mol. Med. (Berl). 92, 913-24 (2014)
  4. Sengle, G., Charbonneau, N.L., Ono, R.N., and Sakai, L.Y. Connective tissue pathways that regulate growth factors. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 7, 27-32 (2008)
  5. Sengle, G, and Sakai, L.Y. Connective Tissue Pathways That Regulate Growth Factors. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8, 42-49 (2013)
Originial publications
  1. Bultmann-Mellin I, Essers J, van Heijingen PM, von Melchner H, Sengle G, Sterner-Kock A. Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice. Dis. Model Mech. 9, 1367-1374 (2016)
  2. Wohl AP, Troilo H, Collins RF, Baldock C, Sengle G. Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1. J. Biol. Chem. 291, 12732-46 (2016)
  3. Schiavinato A, Keene DR, Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G. Targeting of EMILIN-1 and EMILIN-2 to fibrillin microfibrils facilitates their incorporation into the extracellular matrix. J Invest Dermatol. 136, 1150-60 (2016)
  4. Troilo, H., Barrett, A.L., Zuk, A.V., Lockhart-Cairns, M.P., Wohl, A.P., Bayley, C.P., Dajani, R., Tunnicliffe, R.B., Green, L., Jowitt, T.A., Sengle, G., and Baldock, C. Structural characterization of Twisted gastrulation provides insights into opposing functions on the BMP signalling pathway. Matrix Biol. Jan 29. pii: S0945-053X(16)30011-7 (2016)
  5. Pilecki, B., Holm, A.T., Schlosser, A., Moeller, J.B., Wohl, A.P., Zuk, A.V., Heumüller, S.E., Wallis, R., Moestrup, S.K., Sengle, G., Holmskov, U., and Sorensen, G.L. Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation. J. Biol. Chem. 291, 1103-14 (2016)
  6. Sengle, G., Carlberg, V., Tufa, S.F., Charbonneau, N.L., Smaldone, S., Carlson, E.J., Ramirez, F., Keene, D.R., Sakai, L.Y. Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice. PLoS Genet. 11, e1005340 (2015)
  7. Bultmann-Mellin, I., Conradi, A., Maul, A.C., Dinger, K., Wempe, F., Wohl, A.P., Imhof, T., Wunderlich, F.T., Bunck, A.C., Nakamura, T., Koli, K., Bloch, W., Ghanem, A., Heinz, A., von Melchner, H., Sengle, G., and Sterner-Kock, A. Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms. Dis. Model Mech. 8, 403-15 (2015)
  8. Troilo, H., Zuk, A.V., Tunnicliffe, R.B., Wohl, A.P., Berry, R., Collins, R.F., Jowitt, T.A., Sengle, G., and Baldock, C. Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding. Proc Natl Acad Sci U S A. 111, 13063-13068 (2014)
  9. Richardson, R.J., Gebauer, J.M., Zhang, J.L., Kobbe, B., Keene, D.R., Karlsen, K.R., Richetti, S., Wohl, A.P., Sengle, G., Neiss, W.F., Paulsson, M., Hammerschmidt, M., Wagener, R. AMACO is a component of the basement membrane-associated Fraser complex. J. Invest. Dermatol. 134:1313-22 (2014)
  10. Tamminen, J.A., Parviainen, V., Rönty, M., Wohl, A.P., Murray, L., Joenväärä, S., Varjosalo, M., Leppäranta, O., Ritvos, O., Sengle, G., Renkonen, R., Myllärniemi, M., Koli, K. Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug. Oncogenesis. 2:e66 (2013)
  11. Sengle, G., Tufa, S.F., Sakai, L.Y., Zulliger, M.A., and Keene, D.R. A Correlative Method for Imaging Identical Regions of Samples by Micro-CT, Light Microscopy and Electron Microscopy: Imaging Adipose Tissue in a Model System. J. Histochem Cytochem. 2012 Dec 20, in press
  12. Sengle, G., Tsutsui, K., Keene, D.R., Tufa, S.F., Carlson, E.J., Charbonneau, N.L., Ono, R.N., Sasaki, T., Wirtz, M.K., Samples, J.R., Fessler, L.I., Fessler, J.H., Sekiguchi, K., Hayflick, S.J., and Sakai, L.Y. Microenvironmental regulation by fibrillin-1. PLoS Genet. 8, e1002425 (2012).
  13. Sengle, G., Ono, R.N., Sasaki, T., and Sakai, L.Y. Prodomains of transforming growth factor {beta} (TGF{beta}) superfamily members specify different functions: Extracellular Matrix interactions and growth factor bioavailability. J. Biol. Chem. 286, 5087-99 (2011)
  14. Nistala, H., Lee-Arteaga, S., Smaldone, S., Siciliano, G., Carta, L., Ono, R.N., Sengle, G., Arteaga-Solis, E., Levasseur, R., Ducy, P., Sakai, L.Y., Karsenty, G., and Ramirez, F. Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation. J. Cell Biol. 190, 1107-21 (2010)
  15. Charbonneau, N.L., Carlson, E.J., Tufa, S., Sengle, G., Manalo, E.C., Carlberg, V.M., Ramirez, F., Keene, D.R., and Sakai, L.Y. In vivo studies of mutant fibrillin-1 microfibrils. J. Biol. Chem. 285, 24943-55 (2010)
  16. Tsutsui, K., Manabe, R., Yamada, T., Nakano, I., Oguri, Y., Keene, D.R., Sengle, G., Sakai, L.Y., and Sekiguchi, K. ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation. J. Biol. Chem. 285, 4870-82 (2010)
  17. Ono, R.N., Sengle, G., Charbonneau, N.L., Carlberg, V., Bächinger, H.P., Sasaki, T., Lee-Arteaga, S., Zilberberg, L., Rifkin, D.B., Ramirez, F., Chu, M.L., and Sakai, L.Y. Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites. J. Biol. Chem. 284, 16872-81 (2009)
  18. Sengle, G., Ono, R.N., Lyons, K.M., Bächinger, H.P., and Sakai, L.Y. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol. 381, 1025-39 (2008)
  19. Sengle, G., Charbonneau, N.L., Ono, R.N., Sasaki, T., Alvarez, J., Keene, D.R., Bächinger, H.P., and Sakai, L.Y. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J. Biol. Chem. 283, 13874-88 (2008)
  20. Kuo, C.L., Isogai, Z., Keene, D.R., Hazeki, N., Ono, R.N., Sengle, G., Bächinger, H.P., and Sakai, L.Y. Effects of fibrillin-1 degradation on microfibril ultrastructure. J. Biol. Chem. 282, 4007-20 (2007)

21 November 2016
Gerhard Sengle
Institute for Biochemistry II, Joseph-Stelzmann-Strasse 52, D50931 Cologne
Suggestions and wishes: Gudrun Konertz