Gruppe Wagener  
Publikationen

  1. Gioia R, Tonelli F, Ceppi I, Biggiogera M, Leikin S, Fisher S, Tenedini E, Yorgan TA, Schinke T, Tian K, Schwartz JM, Forte F, Wagener R, Villani S, Rossi A, Forlino A. The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta. Hum Mol Genet. May 5. [Epub ahead of print] (2017)

  2. Sabatelli P, Sardone F, Traina F, Merlini L, Santi S, Wagener R and Faldini C. TGF-β1 differentially modulates the collagen VI a5 and a6 chains in human tendon cultures. J. Biol. Regul. Homeost. Agents. 30, 107-113 (2016)

  3. Uckelmann H, Blaszkiewicz S, Nicolae C, Haas S, Schnell A, Wurzer S, Wagener R, Aszodi A, Essers MA. Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4. J Exp Med. 213, 1961-71 (2016)

  4. Sardone F, Santi S, Tagliavini F, Traina F, Merlini L, Squarzoni S, Cescon M, Wagener R, Maraldi NM, Bonaldo P, Faldini C, Sabatelli P. Collagen VI-NG2 axis in human tendon fibroblasts under conditions mimicking injury response. Matrix Biol. 55, 90-105 (2016)

  5. Schiavinato A, Keene DR, Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G. Targeting of EMILIN-1 and EMILIN-2 to fibrillin microfibrils facilitates their incorporation into the extracellular matrix. J Invest Dermatol. 136, 1150-60 (2016)3. Schiavinato A, Keene DR, Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G. Targeting of EMILIN-1 and EMILIN-2 to fibrillin microfibrils facilitates their incorporation into the extracellular matrix. J Invest Dermatol. 136, 1150-60 (2016)

  6. Maaß T, Bayley CP, Mörgelin M, Lettmann S, Bonaldo P, Paulsson M, Baldock C, Wagener R. Heterogeneity of Collagen VI Microfibrils: Structural Analysis of Non-collagenous Regions. J Biol Chem. Jan 7 [Epub ahead of print], (2016)

  7. Gebauer JM, Kobbe B, Paulsson M, Wagener R. Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Matrix Biol. 49, 106-19 (2016), Epub 2015

  8. Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA. Interleukin-4 Receptor a Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair. Immunity, 43, 803-16 (2015)

  9. Becker AK, Mikolajek H, Werner JM, Paulsson M, Wagener R. Characterization of recombinantly expressed matrilin VWA domains. Protein Expr Purif 107C, 20-28 (2015)

  10. Jonas A, Thiem S, Kuhlmann T, Wagener R, Aszodi A, Nowell C, Hagemeier K, Laverick L, Perreau V, Jokubaitis V, Emery B, Kilpatrick T, Butzkueven H, Gresle M. 2014 Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation J. Clin. Invest. 124, 5042-5056 (2014)

  11. Lettmann S, Bloch W, Maaß T, Niehoff A, Schulz JN, Eckes B, Eming SA, Bonaldo P, Paulsson M, Wagener R. Col6a1 Null Mice as a Model to Study Skin Phenotypes in Patients with Collagen VI Related Myopathies: Expression of Classical and Novel Collagen VI Variants during Wound Healing. PLoS One 9, e105686 (2014)

  12. Tagliavini F, Pellegrini C, Sardone F, Squarzoni S, Paulsson M, Wagener R, Gualandi F, Trabanelli C, Ferlini A, Merlini L, Santi S, Maraldi NM, Faldini C, Sabatelli P. Defective collagen VI a6 chain expression in the skeletal muscle of patients with collagen VI-related myopathies. Biochim Biophys Acta 1842, 1604-12 (2014)

  13. Pan TC, Zhang RZ, Arita M, Bogdanovich S, Adams SM, Gara SK, Wagener R, Khurana TS, Birk DE, Chu ML. A Mouse Model for Dominant Collagen VI Disorders: Heterozygous Deletion of Col6a3 Exon 16. J Biol Chem 289 10293-307 (2014)

  14. Neacsu CD, Ko YP, Tagariello A, Røkenes Karlsen K, Neiss WF, Paulsson M, Wagener R. Matrilin-1 is Essential for Zebrafish Development by Facilitating Collagen II Secretion. J Biol Chem 289, 1505-18 (2014)

  15. Becker AK, Mikolajek H, Paulsson M, Wagener R, Werner JM. A novel structure of a collagen VI VWA-domain displays N- and C-termini at opposite sides of the protein. Structure 22 199-208 (2014)

  16. Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Røkenes Karlsen K, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R. AMACO is a Component of the Basement Membrane Associated Fraser Complex. J Invest Dermatol 134 1313-22 (2014)

  17. Bell PA, Wagener R, Zaucke F, Koch M, Selley J, Warwood S, Knight D, Boot-Handford RP, Thornton DJ, Briggs MD. Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures. Biol Open 2, 802-11 (2013)

  18. Klatt AR, Paul-Klausch B, Klinger G, Hillebrand U, Kühn G, Kobbe B, Renno JH, Johannis W, Paulsson M, Wagener R. The matrilin-3 VWA1 domain modulates interleukin-6 release from primary human chondrocytes. Osteoarthritis Cartilage 21, 869-73 (2013)

  19. Sabatelli, P., Gualandi, F., Gara, S.K., Grumati, P., Zamparelli, A., Martoni, E., Pellegrini, C., Merlini, L., Ferlini, A., Bonaldo, P., Maraldi, N.M., Paulsson, M., Squarzoni, S., and Wagener, R. Expression of collagen VI α5 and α6 chains in human muscle and in Duchenne muscular dystrophy–related muscle fibrosis. Matrix Biol. 31, 187-196 (2012)

  20. Schiavinato, A., Becker, A.K., Zanetti, M., Corallo, D., Milanetto, M., Bizzotto, D., Bressan, G., Guljelmovic, M., Paulsson, M., Wagener, R., Braghetta, P., and Bonaldo, P. EMILIN-3, peculiar member of elastin microfibril interface-located protein (EMILIN) family, has distinct expression pattern, forms oligomeric assemblies, and serves as transforming growth factor β (TGF-β) antagonist. J. Biol. Chem. 287, 11498-11515 (2012)

  21. Gara, S.K., Grumati, P., Squarzoni, S., Sabatelli, P., Bonaldo, P., Paulsson, M., and Wagener, R. Differential and restricted expression of novel collagen VI chains in mouse. Matrix Biol. 30, 248-257 (2011)

  22. Groma, G., Grskovic, I., Schael, S., Ehlen, H.W., Wagener, R., Fosang, A., Aszodi, A., Paulsson, M., Brachvogel, B., and Zaucke, F. Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth chondrocytes of defined differentiation state. Matrix Biol. 30, 275-280 (2011)

  23. Iorga, B., Neacsu, C.D. Neiss, W.F., Wagener, R., Paulsson, M., Stehle, R., and Pfitzer, G. Micromechanical function of myofibrils isolated from skeletal and cardiac muscle of the zebrafish. J. Gen. Physiol. 137, 255-270 (2011)

  24. Klatt, A.R., Becker, A.K., Neacsu, C.D., Paulsson, M., and Wagener, R. The matrilins: modulators of extracellular matrix assembly. Int. J. Biochem. Cell Biol. 43, 320-330 (2011)

  25. Neacsu, C.D., Grosch, M., Tejada, M., Winterpacht, A., Paulsson, M., Wagener, R., and Tagariello, A. Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate γ-carboxylation. Matrix Biol. 30, 369-378 (2011)

  26. Sabatelli, P., Gara, S.K., Grumati, P., Urciuolo, A., Gualando, F., Curci, R., Squarzoni, S., Zamparelli, A., Martoni, E, Merlini, L., Paulsson, M., Bonaldo, P., and Wagener, R. Expression of the collagen VI a5 and a6 chains in normal human skin and in patients with collagen VI-related myopathies. J. Invest. Dermatol. 131, 99-107 (2011)

  27. Carney, T.J., Feitosa, N.M., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J.M., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, H., Ingham, P.W., and Hammerschmidt, M. Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. PLoS Genet. 6, e1000907 (2010)

  28. Gebauer, J.M., Rokenes-Karlsen, K., Neiss, W.F., Paulsson, M., and Wagener, R. Expression of the AMACO (VWA2 protein) ortholog in zebrafish. Gene Expr. Patterns 10, 53-59 (2010)

  29. Grimal, S., Puech, S., Wagener, R., Ventéo, S., Carroll, P., and Fichard-Carroll A. Collagen XXVIII is a distinctive component of the peripheral nervous system nodes of ranvier and surrounds nonmyelinating glial cells. Glia 58, 1977-1987 (2010)

  30. Otten, C., Hansen, U., Talke, A., Wagener, R., Paulsson, M., and Zaucke, F. A matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen fibrils. Human Mutation 31, 254-263 (2010)

  31. Ehlen, H.W.A., Sengle, G., Klatt, A.R., Talke, A., Müller, S., Paulsson, M., and Wagener, R. Proteolytic processing causes extensive heterogeneity of tissue matrilin forms. J. Biol. Chem. 284, 21545-21556 (2009)

  32. Gebauer, J.M., Keene, D.R., Olsen, B.R., Sorokin, L.M., Paulsson, M., and Wagener, R. Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment. Matrix Biol. 28, 456-462 (2009)

  33. Klatt, A.R., Klinger, G., Paul-Klausch, B., Kühn, G., Renno, J.H., Wagener, R., Paulsson, M., Schmidt, J., Malchau, G., and Wielckens, K. Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes. FEBS Lett. 583, 3611-3617 (2009)

  34. Malin, D., Sonnenberg-Riethmacher, E., Guseva, D., Wagener, R., Aszodi, A., Irintchev, A., and Rietmacher, D. The extracellular matrix protein matrilin 2 participates in periph-eral nerve regeneration. J. Cell Sci. 122, 995-1004 (2009)

  35. Wagener, R., Gara S.K., Kobbe, B., Paulsson, M., and Zaucke, F. The knee os-teoarthritis locus DVWA on chromosome 3p24.3 is the 5' part of the split COL6A4 gene. Ma-trix Biol. 28, 307-310 (2009)

  36. Gebauer, J.M., Müller, S., Hanisch, F.-G., Paulsson, M., and Wagener, R. O-glucosylation and O-fucosylation occur together in close proximity on the first EGF repeat of AMACO (VWA2 protein). J Biol Chem. 283, 17846-17854 (2008)

  37. Gara S.K., Grumati P., Urciuolo A., Bonaldo P., Kobbe B., Koch M., Paulsson M., Wagener R. Three novel collagen VI chains with high homology to the alpha 3 chain. J Biol Chem. 283, 10658-10670 (2008)

  38. Leighton M.P., Nundlall S., Starborg T., Meadows R.S., Suleman F., Knowles L., Wagener R., Thornton D.J., Kadler K.E., Boot-Handford R.P., Briggs M.D. Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation, Hum Mol Genet. 16, 1728-41 (2007)

  39. Nicolae C., Ko Y.P., Miosge N., Niehoff A., Studer D., Enggist L., Hunziker E.B., Paulsson M., Wagener R., Aszodi A. Abnormal collagen fibrils in cartilage of matrilin-1/matrilin-3-deficient mice, J Biol Chem. 282, 22163-75 (2007)

  40. Mann H.H., Sengle G., Gebauer J.M., Eble J.A., Paulsson M., Wagener R. Matrilins mediate weak cell attachment without promoting focal adhesion formation, Matrix Biol. 26, 167-74 (2007)

  41. Serrano S.M., Kim J., Wang D., Dragulev B., Shannon J.D., Mann H.H., Veit G., Wagener R., Koch M., Fox J.W. The cysteine-rich domain of snake venom metalloproteinases is a ligand for von Willebrand factor A domains: role in substrate targeting, J Biol Chem. 281, 39746-56 (2006)

  42. Veit, G., Kobbe, B., Keene, D.R., Paulsson, M., Koch, M., and Wagener, R. Collagen XXVIII, a novel VWA-domain-containing protein with many imperfections in the collagenous domain. J Biol Chem., 281, 3494-3504 (2006)

  43. Cotterill, S.L., Jackson, G.C., Leighton, M.P., Wagener R., Mäkitie O., Cole W.G., and Briggs M.D. Multiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3. Hum. Mut., 26, 557-565 (2005)

  44. Budde, B., Blumbach, K., Ylöstalo, J., Zaucke, F., Ehlen, H.W.A., Wagener, R., Ala-Kokko, L., Paulsson, M., Bruckner, P., and Grässel, S. Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX. Mol. Cell. Biol., 25, 10465-10478 (2005)

  45. Ko, Y.-P., Kobbe, B., Paulsson, M., and Wagener, R. Zebrafish (Danio rerio) matrilins: Shared and divergent characteristics with their mammalian counterparts. Biochem. J. 386, 267-279 (2005)

  46. Otten, C., Wagener, R., Paulsson, M., and Zaucke, F. Matrilin-3 mutations that cause chondrodysplasias interfere with protein trafficking while a mutation linked to hand osteoarthritis does not. J. Med. Genet.42, 774-779 (2005)

  47. Wagener, R., Ehlen, H.W.A., Ko, Y.P., Kobbe, B., Mann, H.H., Sengle, G. and Paulsson, M. The matrilins - adaptor proteins in the extracellular matrix. FEBS Lett. 579, 3323-3329 (2005)

  48. Ko, Y., Kobbe, B., Nicolae, C., Miosge, N., Paulsson, M., Wagener, R., and Aszodi, A. Matrilin 3 is dispensable for mouse skeletal growth and development. Mol. Cell. Biol. 24, 1691-1699 (2004)

  49. Mann H.H., Özbek, S., Engel, J., Paulsson, M., and Wagener, R. Interactions between COMP and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias. J. Biol. Chem. 279, 25294-25298 (2004)

  50. Sengle, G., Kobbe, B., Mörgelin, M., Paulsson, M., and Wagener, R. Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in kidney. J. Biol. Chem. 278, 50240-50249 (2003)

  51. Wiberg, C., Klatt, A.R., Wagener, R., Paulsson, M., Bateman, J.F., Heinegard, D., and Mörgelin, M. Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. J. Biol. Chem. 278, 37698-37704 (2003)

  52. Klatt, A.R., Paulsson, M., and Wagener, R. Expression of matrilins during maturation of mouse skeletal tissues. Matrix Biol. 21, 289-296 (2002)

  53. Paulsson, M., Klatt, A.R., Kobbe, B., Nitsche, D.P. and Wagener, R. The matrilins: A novel family of extracellular adaptor proteins. In: Hascall, V.C., and Kuettner, K. eds. The many faces of osteoarthritis. Birkhäuser, Basel. pp. 151-158 (2002)

  54. Pullig, O., Weseloh, G., Klatt, A.R., Wagener, R. and Swoboda, B. Matrilin-3 in human articular cartilage: increased expression in osteoarthritis. Osteoarthritis Cartilage. 10, 253-263 (2002)

  55. Klatt, A.R., Paulsson, M. and Wagener, R. Expression of matrilins during maturation of mouse skeletal tissues. Matrix Biol. 21, 289-296 (2002)

  56. Wagener, R., Kobbe, B., Aszódi, A., Aeschlimann, D.and Paulsson, M. Characterization of the mouse matrilin-4 gene: a 5' antiparallel overlap with the gene encoding the transcription factor RBP-l. Genomics. 76, 89-98 (2001)

  57. Klatt, A.R., Nitsche, D.P., Kobbe, B., Macht, M., Paulsson, M. and Wagener, R. Molecular structure, processing, and tissue distribution of matrilin-4. J. Biol. Chem. 276: 17267-17275 (2001)

  58. Wagener, R., Kobbe, B., Aszódi, A., Liu, Z., Beier, D.R., and Paulsson, M. Structure and mapping of the mouse matrilin-3 gene (Matn3), a member of a gene family containing a U12-type AT-AC intron. Mamm. Genome. 11, 85-90 (2000)

  59. Segat, D., Frie, C., Nitsche, P.D., Klatt, A.R., Piecha, D., Korpos, E., Deák, F., Wagener, R., Paulsson, M and Smyth, N. Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart. Matrix Biol. 19, 649-655 (2000)

  60. Klatt, A.R., Nitsche, P.D., Kobbe, B., Mörgelin, M., Paulsson, M., and Wagener, R. Molecular structure and tissue distribution of matrilin-3, a filament-forming extracellular matrix protein expressed during skeletal development. J. Biol. Chem. 275, 3999-4006 (2000)

  61. Deák, F., Wagener, R., Kiss, I., and Paulsson, M. The matrilins: a novel family of oligomeric extracellular matrix proteins. Matrix Biol. 18, 55-66 (1999)

  62. Paulsson, M., Piecha, D., Segat, D., Smyth, N. and Wagener, R. The matrilins: a growing family of A-domain-containing proteins. Biochem Soc Trans. 27, 824-826 (1999)

  63. Wagener, R., Kobbe, B., and Paulsson, M. Genomic organisation, alternative splicing and primary structure of human matrilin-4. FEBS Lett. 438, 165-170 (1998)

  64. Wagener, R., Kobbe, B., and Paulsson, M. Matrilin-4, a new member of the matrilin family of extracellular matrix proteins. FEBS Lett. 436, 123-127 (1998)

  65. Wagener, R., Kobbe, B., and Paulsson, M. Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor. FEBS Lett. 413, 129-134 (1997)

  66. Wagener, R, Kobbe, B und Stoffel, W. Quantification of gangliosides by microbore high performance liquid chromatography. J Lipid Res 37, 1823-1829 (1996)

  67. Wagener, R, Pfitzner, R, und Stoffel, W. Studies on the organization of the human apolipoprotein B 100 gene. Biol Chem Hoppe Seyler 368, 419-425 (1987)

  68. Pfitzner, R, Wagener, R, und Stoffel, W. Isolation, expression and characterization of a human apolipoprotein B 100-specific cDNA clone. Biol Chem Hoppe Seyler 367, 1077-1083 (1986)



08 August 2017
Raimund Wagener
Institut für Biochemie II, Joseph-Stelzmann-Strasse 52, D50931 Köln
Anregungen und Wünsche: Gudrun Konertz
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