Gruppe Zaucke  
Publikation
  1. Groma G, Xin W, Grskovic I, Niehoff A, Paulsson M, Brachvogel B, Zaucke F.
    Abnormal bone quality in COMP and matrilin-3 double deficient mice caused by increased TIMP-3 deposition and delayed aggrecan degradation.
    Arthritis Rheum. 64, 2644-2654 (2012)

  2. Kim DS, Li KW, Boroujerdi A, Yu YP, Deng P, Zhou CY, Park J, Zhang X, Lee J, Coupe M, Sharp K, Steward O, Eroglu C, Barres B, Zaucke F, Xu ZC, Luo ZD.
    Thrombospondin-4 contributes to spinal sensitization and neuropathic pain.
    J. Neurosci. 32, 8977-8987 (2012)

  3. Bechtel M, Keller MV, Bloch W, Sasaki T, Boukamp P, Zaucke F, Paulsson M, Nischt R.
    Different domains in nidogen-1 and nidogen-2 basement membrane formation in skin organotypic cocultures.
    FASEB J. 26, 3637-3648 (2012)

  4. Agarwal P, Zwolanek D, Keene DR, Schulz JN, Blumbach K, Heinegard D, Zaucke F, Koch M, Krieg T, Paulsson M, Eckes B.
    Cartilage Oligomeric Matrix Protein (COMP) – Evidence for a role in regulating skin extracellular matrix suprastructure.
    J. Biol. Chem. 287: 22549–22559 (2012)

  5. Widmer C, Gebauer J, Brunstein E, Rosenbaum S, Zaucke F, Drögemüller C, Loeb T, Baumann U.
    A molecular basis for the action of the collagen-specific chaperone Hsp47/SerpinH1 and its structure-specific client recognition.
    Proc. Natl. Acad. Sci. USA 109, 13243-13247 (2012)

  6. Niehoff A, Müller M, Brüggemann L, Savage T, Zaucke F, Eckstein F, Müller-Lung U, Brüggemann GP.
    Deformational behaviour of knee cartilage and changes in serum cartilage oligomeric matrix protein (COMP) after running and drop landing.
    Osteoarthritis Cartilage. 19, 1003-1010 (2011)

  7. Groma G, Grskovic I, Schael S, Ehlen HW, Wagener R, Fosang A, Aszodi A, Paulsson M, Brachvogel B, Zaucke F.
    Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.
    Matrix Biol. 30, 275-280 (2011)

  8. Hansen U, Platz N, Becker A, Bruckner P, Paulsson M, Zaucke F.
    A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis.,
    Arthritis Rheum. 63, 159-67 (2011)

  9. Belluoccio D, Etich J, Rosenbaum S, Frie C, Grskovic I, Stermann J, Ehlen H, Vogel S, Zaucke F, von der Mark K, Bateman JF, Brachvogel B.
    Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status.
    J. Bone Miner. Res. 25, 1267-81 (2010)

  10. Zaucke F, Boehnlein JM, Steffens S, Polishchuk RS, Rampoldi L, Fischer A, Pasch A, Boehm CW, Baasner A, Attanasio M, Hoppe B, Hopfer H, Beck BB, Sayer JA, Hildebrandt F, Wolf MT.
    Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression.
    Hum. Mol. Genet. 19, 1985-97 (2010)

  11. Otten C, Hansen U, Talke A, Wagener R, Paulsson M, Zaucke F.
    A matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen fibrils.
    Hum Mutat. 31, 254-263 (2010).

  12. Blumbach K, Bastiaansen-Jenniskens YM, DeGroot J, Paulsson M, Van Osch GVJM, Zaucke F.
    Combined role of collagen IX and COMP in cartilage matrix assembly - COMP counteracts collagen IX limitation of cartilage collagen fibril growth.
    Arthritis Rheum. 60, 3676-3685 (2009).

  13. Zaucke F and Grässel S.
    Genetic mouse models for the functional analysis of the perifibrillar proteins collagen IX, COMP and matrilin-3: Implications for growth cartilage differentiation and endochondral ossification.
    Histol. Histopathol. 24, 1067-1079 (2009).

  14. Spohn G, Kleinridders A, Wunderlich FT, Watzka M, Zaucke F, Blumbach K, Geisen C, Seifried E, Müller C, Paulsson M, Brüning JC and Oldenburg J.
    VKORC1 Deficiency in Mice Causes Early Postnatal Lethality Due to Severe Bleeding.
    Thromb Haemost. 101, 1044-1050 (2009)

  15. Wagener R, Gara SK, Kobbe B, Paulsson M and Zaucke F.
    The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the N-terminal part of the split COL6A4 gene.
    Matrix Biol. 28, 307-310 (2009).

  16. Blumbach K., Niehoff A., Paulsson. M and Zaucke F.
    Ablation of collagen IX and COMP disrupts epiphyseal cartilage architecture.
    Matrix Biol. 27, 306-318 (2008).

  17. Schmitz M., Niehoff A., Miosge N., Smyth N., Paulsson M. and Zaucke F.
    Transgenic mice expressing D469 mutated cartilage oligomeric matrix protein (COMP) show mild skeletal abnormalities and sternal malformations.
    Matrix Biol. 27, 67-85 (2008).

  18. Södersten F., Ekman S., Niehoff A., Zaucke F., Heinegard D. and Hultenby K.
    Ultrastructural immunolocalization of cartilage oligomeric matrix protein (COMP), thrombospondin-4 (TSP-4) and collagen fibril size in the rodent Achilles tendon, in relation to exercise.
    Connect. Tissue. Res. 48, 254-262 (2007).

  19. Aigner T., Rau T., Niederhagen M., Zaucke F., Schmitz M., Pöhls U., Stöss H., Rauch A. and Thiel C.T.
    Achondrogenesis IA (Houston-Harris): a still unresolved molecular phenotype.
    Pediatr. Devel. Pathol., 10, 328-334 (2007).

  20. Tolhurst Dunkle E., Zaucke F. and Clegg D.O.
    Thrombospondin-4 and matrix three-dimensionality in axon outgrowth and adhesion in the developing retina.
    Exp. Eye Res., 84, 707-717 (2007).

  21. Wolf M.T.F., Beck B.B., Zaucke F., Kunze A., Misselwitz J., Ruley J., Ronda T., Fischer A., Licht C., Otto E., Hoppe B. and Hildebrandt F.
    The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect.
    Kidney Int., 71, 574-581 (2007).

  22. Schmitz M., Becker A., Schmitz A., Weirich C., Paulsson M., Zaucke F. and Dinser R.
    Disruption of extracellular matrix structure may cause pseudoachondroplasia phenotypes in the absence of impaired COMP secretion.
    J. Biol. Chem. 281, 32587-95 (2006)

  23. Södersten F., Ekman S., Schmitz M., Paulsson M. and Zaucke F.
    Thrombospondin-4 and cartilage oligomeric matrix protein form heterooligomers in equine tendon.
    Connect. Tissue. Res. 47, 85-91 (2006)

  24. Budde B., Blumbach K., Ylöstalo J., Zaucke F., Ehlen H.W.A., Wagener R., Ala-Kokko L., Paulsson M., Bruckner P. and Grässel S.
    Altered integration of matrilin-3 into cartilage extracellular matrix in the absence of collagen IX.
    Mol. Cell. Biol. 25, 10465-10478 (2005)

  25. Otten C., Wagener R., Paulsson M. and Zaucke F.
    Matrilin-3 mutations that cause chondrodysplasias interfere with protein trafficking while a mutation associated with hand osteoarthritis does not.
    J. Med Genet. 42, 774-779 (2005)

  26. Neidhart M., Zaucke F., von Knoch R., Jüngel A., Michel B.A., Gay R.E. and Gay S.
    Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.
    Ann. Rheum. Dis. 64, 419-424 (2005)

  27. Niehoff A., Kersting U.G., Zaucke F., Morlock M. and Brüggemann G.P.
    The effect of dose dependent physical loading on mechanical, morphological, and biochemical properties of the growth plate in the rat model.
    Bone 35, 899-908 (2004)

  28. ihlajamaa T., Lankinen H., Ylöstalo J., Valmu L., Jäälinoja J., Zaucke F., Spitznagel L., Gösling S., Puustinen A., Mörgelin M., Peränen J., Maurer P., Ala-Kokko L. and Kilpeläinen I.
    Characterization of recombinant amino-terminal NC4 domain of human collagen IX Interaction with glycosaminoglycans and cartilage oligomeric matrix protein (COMP).
    J. Biol. Chem. 279, 24265-24273 (2004)

  29. Kaufmann B., Müller S., Hanisch F.G., Hartmann U., Paulsson M., Maurer P. and Zaucke F.
    Structural variability of BM-40/SPARC/osteonectin glycosylation: implications for collagen affinity.
    Glycobiology 14, 609-619 (2004)

  30. Spitznagel L., Nitsche D.P., Paulsson M., Maurer, P. and Zaucke F.
    Characterization of a pseudoachondroplasia-associated mutation (H587R) in the carboxy-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP).
    Biochem. J. 377, 479-487 (2004)

  31. Dinser R., Zaucke F., Kreppel F., Hultenby K., Kochanek S., Paulsson M. and Maurer P.
    Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways.
    J. Clin. Invest. 110, 505-513 (2002)

  32. Zaucke F., Dinser R., Maurer P. and Paulsson M.
    Cartilage oligomeric matrix protein (COMP) and collagen IX are sensitive markers for the differentiation state of primary particular chondrocytes.
    Biochem. J. 358, 17-24 (2001)

  33. Dinser R., Kreppel F., Zaucke F., Blank C., Paulsson M., Kochanek S. and Maurer P.
    Long-term transgene expression in primary articular chondrocytes following nonviral and adenoviral gene transfer.
    Histochem. Cell. Biol. 116: 69-77 (2001)



18 Oktober 2012
Frank Zaucke
Institut für Biochemie II, Joseph-Stelzmann-Strasse 52, D50931 Köln
Anregungen und Wünsche: Budi Tunggal
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