Institute of Neurophysiology


Medical Faculty
University of Cologne

Prof. Dr. A. Sachinidis
Email: 
Phone: +49-221-478-7373
Fax:      +49-221-478-6965

FunGenES

List of Current Research Interests:

• Establishing of transgene embryonic stem cell lineages that can be used for generation of pure population of somatic cells (cardiomyocytes, smooth muscle cells, endothelial cells) and mesodermal cells (BMP2+ and T-Bra+ cells). Identification of genes and gene signatures specific for somatic and mesodermal cells applying large-scale gene expression methodologies. Functional analysis of not annotated “unknown genes” genes applying “gain of function” and “loss of function” molecular biology methodologies in embryonic stem cells. Functional analysis of candidate genes using the zebra fish model (in cooperation with the Department of Genetics, University of Cologne).
   
• Selective differentiation of embryonic stem cells to different tissue specific cell types. Identification of small signal molecules and signal transduction pathways promoting cardiomyogenesis
   
• Biochemistry and molecular biology of the intracellular signaling transduction pathway of mitogenic signals in cells participating in the development of proliferative diseases. Identification and functional analysis of differentially expressed genes in proliferating cells to characterize genes responsible for mitogenicity and malignant transformation. Testing of various pharmacological substances with the purpose of interrupting growth processes of either non-malignant proliferative (cardiovascular) or malignant proliferative (tumour) processes.

Publication List: