Institute of Neurophysiology


Medical Faculty
University of Cologne

Prof. Dr. Toni Schneider

Email:

Phone: +49-221-478-6946
Fax:      +49-221-478-6965

Students UK-online

Doctoral thesis

 

Research interests

• Channelopathies (Ionenkanal-Krankheiten) are caused by defects either in an ion conducting or an
  associated auxiliary subunit of the channel, or by interacting partners. We are focused on structure and
  function of a voltage-dependent Ca2+-channel containing the Cav2.3 E-type subunit, the formerly
  called “pharmacoresistant” (R-type) calcium channel. In 1994 the human Ca_v2.3 was cloned
  independently in two different groups (Williams M.E. et al., Harpold M.M. & Ellis S.B., 1994 and
  Schneider T. et al., Stefani E. & Birnbaumer L. 1994). Its gene inactivation in mice has given us access
  to its physiological function which is related to the cardiac, the endocrine and the neuronal system.
• Protein interaction partners of the voltage-gated Ca²⁺-channel proteins have been detected. They
  connect ion channel activity with cellular functions helping us to explore molecular mechanisms of
  channelopathies related to arrhythmia, hormone release dysfunction, and neuronal disorders like
  epilepsy.

Current research projects:

• Cardiac arrhythmia   (Coworkers: Renate Clemens; Dr. Thomas Galetin ; Etienne E. Tevoufouet, MSc;
  Felix Neumaier, BSc)
• Rhythm generation, synchronization and disease    (Coworkers, Renate Clemens, Ärztin Nora Matar ,
  Arztin Elena Schlapakow, cand. med. Henrik Struck; Heiko Wrubel, cand. med. Wei Jin,
  cand. med. Angela Münch)
• Secretion & neurotransmitter release / endocytosis           (Dr. Kayalvizhi Radhakrishnan,
  Arzt Andreas Krieger, Arzt Dr. Marcel Kamp)
• Interaction partners of R-type / E-type        (Coworkers, Dr. Kayalvizhi Radhakrishnan,
  Arzt Andreas Krieger, Arzt Dr. Marcel Kamp, Etienne E. Tevoufouet, MSc; cand. med. Dimitar Evdokimov;
  Maxine Dibué, MSc; Serdar Alpdogan); Isha Akhtar;Tierärztin Sabrina Scharf
• Retina                                                (Project in the "W. Sickel Laboratory of the Superfused
  Retina" in Cooperation with PD Dr. C. Lüke. Coworkers: Arzt Dr. Siarhei Siapich,
  cand. med. dent. Mehran Maghsoodian, Arzt Dr. Mohammed Banat,
  Arzt Dr. Walid Albanna; cand. med. Ramzi Abumuaileq; cand.med. Mohammad Hijazi; Zahnarzt Mohammad
  Rassaei

Publications (1997 - present)  

Publications (1987 - 1995)