Ausgewählte Publikationen

 

 

Chalovich JM, Lutz E, Baxley T, Schroeter MM (2011)
Acrylodan-labeled smooth muscle tropomyosin reports differences in the effects of troponin and caldesmon in the transition from the active state to the inactive state.
Biochemistry. 2011;50(27): 6093-101

Kaya Z, Leib C, Werfel S, Göser S, Öttl R, Leuchs B, Pfitzer G, Katus HA, Müller OJ (2011)
Comparison of IL-10 and MCP-1-7ND gene transfer with AAV9 vectors for protection from murine autoimmune myocarditis.
Cardiovasc Res. 2011;91(1): 116-23

Fatima A, Xu G, Shao K, Papadopoulos S, Lehmann M, Arnáiz-Cot JJ, Rosa AO, Nguemo F, Matzkies M, Dittmann S, Stone SL, Linke M, Zechner U,
Beyer V, Hennies HC, Rosenkranz S, Klauke B, Parwani AS, Haverkamp W, Pfitzer G
, Farr M, Cleemann L, Morad M, Milting H, Hescheler J, Saric T (2011)
In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells.
Cell Physiol Biochem. 2011;28(4): 579-92

Leib C, Göser S, Lüthje D, Öttl R, Tretter T, Lasitschka F, Zittrich S, Pfitzer G, Katus HA, Kaya Z (2011)
Role of the cholinergic antiinflammatory pathway in murine autoimmune myocarditis.
Circ Res. 2011;109(2): 130-40
 
Vlahou G, Eliá? M, von Kleist-Retzow JC, Wiesner RJ, Wiesner RJ, Rivero F (2011)
The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum.
Eur J Cell Biol. 2011;90(4): 342-55
 
Volz HC, Buss SJ, Li J, Göser S, Andrassy M, Ottl R, Pfitzer G, Katus HA, Kaya Z (2011)
Autoimmunity against cardiac troponin I in ischaemia reperfusion injury.
Eur J Heart Fail. 2011;13(10): 1052-9
 
Li J, Göser S, Leuschner F, Volz HC, Buss S, Andrassy M, Ottl R, Pfitzer G, Katus HA, Kaya Z (2011)
Mucosal tolerance induction in autoimmune myocarditis and myocardial infarction.
Int J Cardiol. 2011

Iorga B, Neacsu CD, Neiss WF, Wagener R, Paulsson M, Stehle R, Pfitzer G (2011)
Micromechanical function of myofibrils isolated from skeletal and cardiac muscles of the zebrafish.
J Gen Physiol. 2011;137(3): 255-70

Schubert R, Gainullina D, Lubomirov L, Kalenchuk V, Sofronova S, Pfitzer G, Tarasova O (2011)
Disappearance of an endothelial brake on vasoconstrictor-induced contractions: functional remodelling during postnatal development
J Vasc Res. 2011;48 1: 175-175
 
Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T, Tobin DJ, Paus R, Wiesner RJ
The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells.
Stem Cells. 2011;29(9): 1459-68
 
Ketterer C, Zeiger U, Budak MT, Rubinstein NA, Khurana TS (2010)
Identification of the neuromuscular junction transcriptome of extraocular muscle by laser capture microdissection.
Invest Ophthalmol Vis Sci. 2010;51(9): 4589-99

 

Baby SM, Bogdanovich S, Willmann G, Basu U, Lozynska O, Khurana TS (2010)
Differential expression of utrophin-A and -B promoters in the central nervous system (CNS) of normal and dystrophic mdx mice.
Brain Pathol. 2010;20(2): 323-42

 

Wiesner, R (Wiesner, R.); Neuhaus, J (Neuhaus, J.); Baris, O (Baris, O.) (2010)
Accumulation of mitochondrial DNA deletions during aging
SPRINGER HEIDELBERG, TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY

 

Eifinger, F (Eifinger, F.)1; Dercks, E (Dercks, E.)1; Roth, B (Roth, B.)1; Pfitzer, G (Pfitzer, G.)2  (2010)
Murine neonatal Intestinal Muscles respond less sensitive to cAMP/PKA Induced Ralaxation in Comparison to the cGMP/PKG Pathway
GEORG THIEME VERLAG KG, RUDIGERSTR 14, D-70469 STUTTGART, GERMANY 

Poeggeler B, Knuever J, Gáspár E, Bíró T, Klinger M, Bodó E, Wiesner RJ, Wenzel BE, Paus R. (2010)
Thyrotropin powers human mitochondria.
FASEB J. 2010 May;24(5):1525-31. Epub 2010 Jan 14  

Hamden SS, Schroeter MM, Chalovich JM. (2010)
Phosphorylation of caldesmon at sites between residues 627 and 642 attenuates inhibitory activity and contributes to a reduction in Ca2+-calmodulin affinity.
Biophys J. 2010 Sep 22;99(6):1861-8

 

Stehle R. and Iorga B. (2010)

Kinetics of cardiac sarcomeric processes and rate-limiting steps in contraction and relaxation.

J Mol Cell Cardiol 48: 843-850, [link]

 

Shcherbakova O., Serebryanaya D., Postnikov A., Schroeter M. M., Zittrich S., Noegel A. A., Shirinsky V., Vorotnikov A., and Pfitzer G. (2010)

Kinase related protein / telokin inhibits Ca2+-independent contraction in triton skinned guinea pig taenia coli.

Biochem J, [link]

 

Neppl Rl, Lubomirov Lt, Momotani K, Pfitzer G, Eto M, and Somlyo Av, (2009)

Thromboxane A2-induced bi-directional regulation of cerebral arterial tone.

J Biol Chem 284: 6348-6360, [link]

 

Stehle R, Solzin J, Iorga B, and Poggesi C, (2009)

Insights into the kinetics of Ca2+-regulated contraction and relaxation from myofibril studies.

Pflugers Arch 458: 337-357, [link]

 

Neulen A, Stehle R, and Pfitzer G, (2009)

The cardiac troponin C mutation Leu29Gln found in a patient with hypertrophic
cardiomyopathy does not alter contractile parameters in skinned murine myocardium.

Basic Res Cardiol 104: 751-760, [link]

 

Puetz S, Lubomirov Lt, and Pfitzer G, (2009)

Regulation of smooth muscle contraction by small GTPases.

Physiology (Bethesda) 24: 342-356, [link]
http://physiologyonline.physiology.org/

Iorga B, Blaudeck N, Solzin J, Neulen A, Stehle I, Lopez Davila A, Pfitzer G, and Stehle R, (2008)

Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils.

Cardiovasc Res 77: 676-686, [link]

 

Kaya Z, Goser S, Buss Sj, Leuschner F, Ottl R, Li J, Volkers M, Zittrich S, Pfitzer G, Rose Nr, and Katus Ha, (2008)

Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis.

Circulation 118: 2063-2072, [link]

 

Leuschner F, Li J, Goser S, Reinhardt L, Ottl R, Bride P, Zehelein J, Pfitzer G, Remppis A, Giannitsis E, Katus Ha, and Kaya Z, (2008)

Absence of auto-antibodies against cardiac troponin I predicts improvement of left ventricular function after acute myocardial infarction.

Eur Heart J 29: 1949-1955, [link]

 

Doring B, Pfitzer G, Adam B, Liebregts T, Eckardt D, Holtmann G, Hofmann F, Feil S, Feil R, and Willecke K, (2007)

Ablation of connexin43 in smooth muscle cells of the mouse intestine: functional insights into physiology and morphology.

Cell Tissue Res 327: 333-342, [link]

 

Iorga B, Adamek N, and Geeves Ma, (2007)

The slow skeletal muscle isoform of myosin shows kinetic features common to smooth and non-muscle myosins.

J Biol Chem 282: 3559-3570, [link]

 

Neulen A, Blaudeck N, Zittrich S, Metzler D, Pfitzer G, and Stehle R, (2007)

Mn2+-dependent protein phosphatase 1 enhances protein kinase A-induced Ca2+ desensitisation in skinned murine myocardium.

Cardiovasc Res 74: 124-132, [link]

 

Peche V, Shekar S, Leichter M, Korte H, Schroder R, Schleicher M, Holak Ta, Clemen Cs, Ramanath Yb, Pfitzer G, Karakesisoglou I, and Noegel Aa, (2007)

CAP2, cyclase-associated protein 2, is a dual compartment protein.

Cell Mol Life Sci 64: 2702-2715, [link]

 

Schaefer A, Matthess H, Pfitzer G, and Kohle K, (2007)

[Mental health and performance of medical students with high and low test anxiety].

Psychother Psychosom Med Psychol 57: 289-297, [link]

 

Solzin J, Iorga B, Sierakowski E, Gomez Alcazar Dp, Ruess Df, Kubacki T, Zittrich S, Blaudeck N, Pfitzer G, and Stehle R, (2007)

Kinetic mechanism of the Ca2+-dependent switch-on and switch-off of cardiac troponin in myofibrils.

Biophys J 93: 3917-3931, [link]

 

Stehle R, Iorga B, and Pfitzer G, (2007)

Calcium regulation of troponin and its role in the dynamics of contraction and relaxation.

Am J Physiol Regul Integr Comp Physiol 292: R1125-1128, [link]

 

Zobel C, Rana Or, Saygili E, Bolck B, Saygili E, Diedrichs H, Reuter H, Frank K, Muller-Ehmsen J, Pfitzer G, and Schwinger Rh, (2007)

Mechanisms of Ca2+-dependent calcineurin activation in mechanical stretch-induced hypertrophy.

Cardiology 107: 281-290, [link]

 

Goser S, Andrassy M, Buss Sj, Leuschner F, Volz Ch, Ottl R, Zittrich S, Blaudeck N, Hardt Se, Pfitzer G, Rose Nr, Katus Ha, and Kaya Z, (2006)

Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium.

Circulation 114: 1693-1702, [link]

 

Lubomirov Lt, Reimann K, Metzler D, Hasse V, Stehle R, Ito M, Hartshorne Dj, Gagov H, Pfitzer G, and Schubert R, (2006)

Urocortin-induced decrease in Ca2+ sensitivity of contraction in mouse tail arteries is attributable to cAMP-dependent dephosphorylation of MYPT1 and activation of myosin light chain phosphatase.

Circ Res 98: 1159-1167, [link]

 

Lubomirov Lt, Schubert R, Gagov Hs, Duridanova Db, and Pfitzer G, (2006)

[Urocortin decreases phosphorylation of MYPT1 and increases the myosin phosphatase activity via elevation of the intracellular level of cAMP].

Biofizika 51: 773-780, [link]

 

Pfitzer G, Lubomirov Lt, Reimann K, Gagov H, and Schubert R, (2006)

Regulation of the crossbridge cycle in vascular smooth muscle by cAMP signalling.

J Muscle Res Cell Motil 27: 445-454, [link]

 

Stehle R, Solzin J, Iorga B, Gomez D, Blaudeck N, and Pfitzer G, (2006)

Mechanical properties of sarcomeres during cardiac myofibrillar relaxation: stretch-induced cross-bridge detachment contributes to early diastolic filling.

J Muscle Res Cell Motil 27: 423-434, [link]

 

Telley Ia, Denoth J, Stussi E, Pfitzer G, and Stehle R, (2006)

Half-sarcomere dynamics in myofibrils during activation and relaxation studied by tracking fluorescent markers.

Biophys J 90: 514-530, [link]

 

Telley Ia, Stehle R, Ranatunga Kw, Pfitzer G, Stussi E, and Denoth J, (2006)

Dynamic behaviour of half-sarcomeres during and after stretch in activated rabbit psoas myofibrils: sarcomere asymmetry but no 'sarcomere popping'.

J Physiol 573: 173-185, [link]

 

Wenzel D, Schmidt A, Reimann K, Hescheler J, Pfitzer G, Bloch W, and Fleischmann Bk, (2006)

Endostatin, the proteolytic fragment of collagen XVIII, induces vasorelaxation.

Circ Res 98: 1203-1211, [link]

 

Zhang Zg, Bothe I, Hirche F, Zweers M, Gullberg D, Pfitzer G, Krieg T, Eckes B, and Aumailley M, (2006)

Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin.

J Cell Sci 119: 1886-1895, [link]

 

Kruger M, Zittrich S, Redwood C, Blaudeck N, James J, Robbins J, Pfitzer G, and Stehle R, (2005)

Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils.

J Physiol 564: 347-357, [link]

 

Poggesi C, Tesi C, and Stehle R, (2005)

Sarcomeric determinants of striated muscle relaxation kinetics.

Pflugers Arch 449: 505-517, [link]

 

Pfitzer G, Schroeter M, Hasse V, Ma J, Rosgen Kh, Rosgen S, and Smyth N, (2005)

Is myosin phosphorylation sufficient to regulate smooth muscle contraction?

Adv Exp Med Biol 565: 319-328; discussion 328, 405-315, [link]

 

Klockner U, Pereverzev A, Leroy J, Krieger A, Vajna R, Pfitzer G, Hescheler J, Malecot Co, and Schneider T, (2004)

The cytosolic II-III loop of Cav2.3 provides an essential determinant for the phorbol ester-mediated stimulation of E-type Ca2+ channel activity.

Eur J Neurosci 19: 2659-2668, [link]

 

Daub B, Schroeter M, Pfitzer G, and Ganitkevich V, (2003)

Expression of members of the S100 Ca2+-binding protein family in guinea-pig smooth muscle.

Cell Calcium 33: 1-10, [link]

 

Gunduz D, Hirche F, Hartel Fv, Rodewald Cw, Schafer M, Pfitzer G, Piper Hm, and Noll T, (2003)

ATP antagonism of thrombin-induced endothelial barrier permeability.

Cardiovasc Res 59: 470-478, [link]

 

Kruger M, Pfitzer G, and Stehle R, (2003)

Expression and purification of human cardiac troponin subunits and their functional incorporation into isolated cardiac mouse myofibrils.

J Chromatogr B Analyt Technol Biomed Life Sci 786: 287-296, [link]

 

Leroy J, Pereverzev A, Vajna R, Qin N, Pfitzer G, Hescheler J, Malecot Co, Schneider T, and Klockner U, (2003)

Ca2+-sensitive regulation of E-type Ca2+ channel activity depends on an arginine-rich region in the cytosolic II-III loop.

Eur J Neurosci 18: 841-855, [link]

 

Pfitzer G, Wirth A, Lucius C, Brkic-Koric D, Manser E, De Lanerolle P, and Arner A, (2003)

Regulation of smooth muscle contraction by calcium, monomeric GTPases of the Rho subfamily and their effector kinases.

Adv Exp Med Biol 538: 89-99; discussion 99, [link]

 

Siedner S, Kruger M, Schroeter M, Metzler D, Roell W, Fleischmann Bk, Hescheler J, Pfitzer G, and Stehle R, (2003)

Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart.

J Physiol 548: 493-505, [link]

 

Stehle R, Kruger M, and Pfitzer G, (2003)

Does cross-bridge activation determine the time course of myofibrillar relaxation?

Adv Exp Med Biol 538: 469-479; discussion 479, [link]

 

Wirth A, Schroeter M, Kock-Hauser C, Manser E, Chalovich Jm, De Lanerolle P, and Pfitzer G, (2003)

Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1.

J Physiol 549: 489-500, [link]

 

Bonnevier J, Malmqvist U, Sonntag D, Schroeter M, Nilsson H, Pfitzer G, and Arner A, (2002)

Sustained norepinephrine contraction in the rat portal vein is lost when Ca(2+) is replaced with Sr(2+).

Am J Physiol Cell Physiol 282: C845-852, [link]

 

Ganitkevich V, Hasse V, and Pfitzer G, (2002)

Ca2+-dependent and Ca2+-independent regulation of smooth muscle contraction.

J Muscle Res Cell Motil 23: 47-52, [link]

 

Pereverzev A, Leroy J, Krieger A, Malecot Co, Hescheler J, Pfitzer G, Klockner U, and Schneider T, (2002)

Alternate splicing in the cytosolic II-III loop and the carboxy terminus of human E-type voltage-gated Ca(2+) channels: electrophysiological characterization of isoforms.

Mol Cell Neurosci 21: 352-365, [link]

 

Pereverzev A, Vajna R, Pfitzer G, Hescheler J, Klockner U, and Schneider T, (2002)

Reduction of insulin secretion in the insulinoma cell line INS-1 by overexpression of a Ca(v)2.3 (alpha1E) calcium channel antisense cassette.

Eur J Endocrinol 146: 881-889, [link]

 

Roell W, Lu Zj, Bloch W, Siedner S, Tiemann K, Xia Y, Stoecker E, Fleischmann M, Bohlen H, Stehle R, Kolossov E, Brem G, Addicks K, Pfitzer G, Welz A, Hescheler J, and Fleischmann Bk, (2002)

Cellular cardiomyoplasty improves survival after myocardial injury.

Circulation 105: 2435-2441, [link]

 

Stehle R, Kruger M, and Pfitzer G, (2002)

Force kinetics and individual sarcomere dynamics in cardiac myofibrils after rapid ca(2+) changes.

Biophys J 83: 2152-2161, [link]

 

Stehle R, Kruger M, Scherer P, Brixius K, Schwinger Rh, and Pfitzer G, (2002)

Isometric force kinetics upon rapid activation and relaxation of mouse, guinea pig and human heart muscle studied on the subcellular myofibrillar level.

Basic Res Cardiol 97 Suppl 1: I127-135, [link]

 

Pfitzer G, (2001)

Invited review: regulation of myosin phosphorylation in smooth muscle.

J Appl Physiol 91: 497-503, [link]

 

Pfitzer G, Sonntag-Bensch D, and Brkic-Koric D, (2001)

Thiophosphorylation-induced Ca(2+) sensitization of guinea-pig ileum contractility is not mediated by Rho-associated kinase.

J Physiol 533: 651-664, [link]

 

Stehle R, Lionne C, Travers F, and Barman T, (2000)

Kinetics of the initial steps of rabbit psoas myofibrillar ATPases studied by tryptophan and pyrene fluorescence stopped-flow and rapid flow-quench. Evidence that cross-bridge detachment is slower than ATP binding.

Biochemistry 39: 7508-7520, [link]

 

Wieneke S, Stehle R, Li Z, and Jockusch H, (2000)

Generation of tension by skinned fibers and intact skeletal muscles from desmin-deficient mice.

Biochem Biophys Res Commun 278: 419-425, [link]

 

Arner A and Pfitzer G, (1999)

Regulation of cross-bridge cycling by Ca2+ in smooth muscle.

Rev Physiol Biochem Pharmacol 134: 63-146, [link]

 

Lucius C, Arner A, Steusloff A, Troschka M, Hofmann F, Aktories K, and Pfitzer G, (1998)

Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins.

J Physiol 506 (Pt 1): 83-93, [link]

 

Pfitzer G and Arner A, (1998)

Involvement of small GTPases in the regulation of smooth muscle contraction.

Acta Physiol Scand 164: 449-456, [link]

 

Wagner Kd, Geil D, Schimke I, Stauss Hm, Lammerich A, Theres H, Pfitzer G, Vetter R, and Gunther J, (1998)

Decreased susceptibility of contractile function to hypoxia/reoxygenation in chronic infarcted rat hearts.

J Mol Cell Cardiol 30: 2341-2353, [link]

 

Albrecht K, Schneider A, Liebetrau C, Ruegg Jc, and Pfitzer G, (1997)

Exogenous caldesmon promotes relaxation of guinea-pig skinned taenia coli smooth muscles: inhibition of cooperative reattachment of latch bridges?

Pflugers Arch 434: 534-542, [link]

 

Katoch Ss, Ruegg Jc, and Pfitzer G, (1997)

Differential effects of a K+ channel agonist and Ca2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle.

Pflugers Arch 433: 472-477, [link]

 

Wagner Kd, Theres H, Born A, Strube S, Wunderlich N, Pfitzer G, Baumann G, and Gunther J, (1997)

Contractile function of papillary muscle from rats with different infarct size after beta-adrenergic blockade and ACE-inhibition.

J Mol Cell Cardiol 29: 2941-2951, [link]

 

Otto B, Steusloff A, Just I, Aktories K, and Pfitzer G, (1996)

Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea-pig intestinal smooth muscle.

J Physiol 496 (Pt 2): 317-329, [link]

 

Lammerich A, Gunther J, Pfitzer G, Storch E, and Vetter R, (1995)

Alterations of cardiac contractile function are related to changes in membrane calcium transport in spontaneously hypertensive rats.

J Hypertens 13: 1313-1324, [link]

 

Lehmann-Klose S, Beinbrech B, Cuppoletti J, Gratzl M, Ruegg Jc, and Pfitzer G, (1995)

Ca(2+)- and GTP[gamma S]-induced translocation of the glucose transporter, GLUT-4, to the plasma membrane of permeabilized cardiomyocytes determined using a novel immunoprecipitation method.

Pflugers Arch 430: 333-339, [link]

 

Schmidt Us, Troschka M, and Pfitzer G, (1995)

The variable coupling between force and myosin light chain phosphorylation in Triton-skinned chicken gizzard fibre bundles: role of myosin light chain phosphatase.

Pflugers Arch 429: 708-715, [link]

 

Steusloff A, Paul E, Semenchuk La, Di Salvo J, and Pfitzer G, (1995)

Modulation of Ca2+ sensitivity in smooth muscle by genistein and protein tyrosine phosphorylation.

Arch Biochem Biophys 320: 236-242, [link]

 

Di Salvo J, Pfitzer G, and Semenchuk La, (1994)

Protein tyrosine phosphorylation, cellular Ca2+, and Ca2+ sensitivity for contraction of smooth muscle.

Can J Physiol Pharmacol 72: 1434-1439, [link]

 

Satoh S, Kreutz R, Wilm C, Ganten D, and Pfitzer G, (1994)

Augmented agonist-induced Ca(2+)-sensitization of coronary artery contraction in genetically hypertensive rats. Evidence for altered signal transduction in the coronary smooth muscle cells.

J Clin Invest 94: 1397-1403, [link]

 

Di Salvo J, Steusloff A, Semenchuk L, Satoh S, Kolquist K, and Pfitzer G, (1993)

Tyrosine kinase inhibitors suppress agonist-induced contraction in smooth muscle.

Biochem Biophys Res Commun 190: 968-974, [link]

 

Pfitzer G, Fischer W, and Chalovich Jm, (1993)

Phosphorylation-contraction coupling in smooth muscle: role of caldesmon.

Adv Exp Med Biol 332: 195-202; discussion 202-193, [link]

 

Pfitzer G, Zeugner C, Troschka M, and Chalovich Jm, (1993)

Caldesmon and a 20-kDa actin-binding fragment of caldesmon inhibit tension development in skinned gizzard muscle fiber bundles.

Proc Natl Acad Sci U S A 90: 5904-5908, [link]

 

Satoh S, Rensland H, and Pfitzer G, (1993)

Ras proteins increase Ca(2+)-responsiveness of smooth muscle contraction.

FEBS Lett 324: 211-215, [link]

 

Boels Pj and Pfitzer G, (1992)

Relaxant effect of phalloidin on Triton-skinned microvascular and other smooth muscle preparations.

J Muscle Res Cell Motil 13: 71-80, [link]

 

Pfitzer G, Strauss Jd, and Ruegg Jc, (1992)

Modulation of myosin phosphorylation-contraction coupling in skinned smooth muscle.

Jpn J Pharmacol 58 Suppl 2: 23P-28P, [link]

 

Boels Pj, Troschka M, Ruegg Jc, and Pfitzer G, (1991)

Higher Ca2+ sensitivity of triton-skinned guinea pig mesenteric microarteries as compared with large arteries.

Circ Res 69: 989-996, [link]

 

Pfitzer G and Boels Pj, (1991)

Differential skinning of smooth muscle: a new approach to excitation-contraction coupling.

Blood Vessels 28: 262-267, [link]

 

Ruegg Jc and Pfitzer G, (1991)

Contractile protein interactions in smooth muscle.

Blood Vessels 28: 159-163, [link]

 

Fischer W and Pfitzer G, (1989)

Rapid myosin phosphorylation transients in phasic contractions in chicken gizzard smooth muscle.

FEBS Lett 258: 59-62, [link]

 

Wagner J, Pfitzer G, and Ruegg Jc, (1987)

Calcium/calmodulin activation of gizzard skinned fibers at low levels of myosin phosphorylation.

Prog Clin Biol Res 245: 427-436, [link]

 

Pfitzer G, Merkel L, Ruegg Jc, and Hofmann F, (1986)

Cyclic GMP-dependent protein kinase relaxes skinned fibers from guinea pig taenia coli but not from chicken gizzard.

Pflugers Arch 407: 87-91, [link]

 

Pfitzer G, Ruegg Jc, Zimmer M, and Hofmann F, (1985)

Relaxation of skinned coronary arteries depends on the relative concentrations of Ca2+, calmodulin and active cAMP-dependent protein kinase.

Pflugers Arch 405: 70-76, [link]

 

Ruegg Jc and Pfitzer G, (1985)

Modulation of calcium sensitivity in guinea pig taenia coli: skinned fiber studies.

Experientia 41: 997-1001, [link]

 

Thomas G, Gross R, Pfitzer G, and Ruegg Jc, (1985)

The positive inotropic dihydropyridine Bay K 8644 does not affect calcium sensitivity or calcium release of skinned cardiac fibres.

Naunyn Schmiedebergs Arch Pharmacol 328: 378-381, [link]

 

Merkel L, Meisheri Kd, and Pfitzer G, (1984)

The variable relation between myosin light-chain phosphorylation and actin-activated ATPase activity in chicken gizzard smooth muscle. Modulation by tropomyosin.

Eur J Biochem 138: 429-434, [link]

 

Pfitzer G, Hofmann F, Disalvo J, and Ruegg Jc, (1984)

cGMP and cAMP inhibit tension development in skinned coronary arteries.

Pflugers Arch 401: 277-280, [link]

 

Pfitzer G and Ruegg Jc, (1984)

Forskolin inhibits tension development in detergent-treated cardiac muscle fibers.

Experientia 40: 65-67, [link]

 

Ruegg Jc, Kuhn Hj, Guth K, Pfitzer G, and Hofmann F, (1984)

Tension transients in skinned muscle fibres of insect flight muscle and mammalian cardiac muscle: effect of substrate concentration and treatment with myosin light chain kinase.

Adv Exp Med Biol 170: 605-615, [link]

 

Ruegg Jc, Pfitzer G, Eubler D, and Zeugner C, (1984)

Effect on contractility of skinned fibres from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methy l-3(2H)- pyridazinone.

Arzneimittelforschung 34: 1736-1738, [link]

 

Ruegg Jc, Pfitzer G, Zimmer M, and Hofmann F, (1984)

The calmodulin fraction responsible for contraction in an intestinal smooth muscle.

FEBS Lett 170: 383-386, [link]

 

Sparrow Mp, Pfitzer G, Gagelmann M, and Ruegg Jc, (1984)

Effect of calmodulin, Ca2+, and cAMP protein kinase on skinned tracheal smooth muscle.

Am J Physiol 246: C308-314, [link]

 

Ruegg Jc, Meisheri K, Pfitzer G, and Zeugner C, (1983)

Skinned coronary smooth muscle: calmodulin, calcium antagonists, and cAMP influence contractility.

Basic Res Cardiol 78: 462-471, [link]

 

Metzger H, Stern Ho, Pfitzer G, and Ruegg Jc, (1982)

Calcium antagonists affect calmodulin-dependent contractility of a skinned smooth muscle.

Arzneimittelforschung 32: 1425-1427, [link]

 

Pfitzer G, Peterson Jw, and Ruegg Jc, (1982)

Length dependence of calcium activated isometric force and immediate stiffness in living and glycerol extracted vascular smooth muscle.

Pflugers Arch 394: 174-181, [link]

 

Pfitzer G, Ruegg Jc, Flockerzi V, and Hofmann F, (1982)

cGMP-dependent protein kinase decreases calcium sensitivity of skinned cardiac fibers.

FEBS Lett 149: 171-175, [link]

 

Herzig Jw, Kohler G, Pfitzer G, Ruegg Jc, and Wolffle G, (1981)

Cyclic AMP inhibits contractility of detergent treated glycerol extracted cardiac muscle.

Pflugers Arch 391: 208-212, [link]




Buchbeiträge:

Pfitzer G., Peterson J.W., (1980) Stiffness of the arterial wall in response to potassium and pharmacological activation. In: Adaptability of the vascular wall. Reinis et al. (eds.) Springer Verlag Berlin, Heidelberg, New York, 125-127.


Pfitzer G., Rüegg J.C., (1984) Biochemical regulation of the smooth muscle contraction. In: Pharmacology of the Vascular Wall. Esplugues J. (ed.) University Press, Valencia, 47-59.

 Rüegg J.C., Sparrow M.P., Mrwa U., Schneider M., Pfitzer G., (1984) Calcium and calmodulin dependent regulatory mechanisms in chemically skinned smooth muscle. In: Smooth Muscle Contraction. Stephens N.L. (ed.) Marcel Dekker, Inc. New York, 361-372.

Rüegg J.C., Kuhn H.J., Güth K., Pfitzer G., Hofmann F., (1984) Tension transients in skinned muscle fibres of insect flight muscle and mammalian cardiac muscle: effect of substrate concentration and treatment with myosin light chain kinase. In: Contractile Mechanisms in Muscle. Advances in Experimental Medicine and Biology. Pollack G.J. and Sugi H. (eds.) Plenum Press, New York, London. Vol. 170, 605-615.

 Rüegg J.C., Pfitzer G., (1985) Excitation-contraction coupling in coronary smooth muscle. In: The Regulation of Heart Function.
Rupp H. (ed.) Thieme, New York.

 
Pfitzer, G. und Katoch, S. (1991) Relaxation of smooth muscle at high levels of myosin light chain (MLC) phosphorylation. In: Cellular regulation by protein phosphorylation. Heilmeyer L.M.G., Jr (ed.). Springer, Berlin, Heidelberg, New York, NATO/ASI Series. Series H: Cell Biology, 58, 459-464.


Boels P.J. und Pfitzer, G. (1991) Different mechanical and biochemical properties of skinned arterioles and arteries. in: Resistance arteries, structure and function. Mulvany, M.J. et al. (eds). Elsevier Science Publishers Amsterdam, 77-80.


Pfitzer, G. und Rüegg, J.C. (1992) Smooth muscle activation. In: Advances in comparative and environmental physiology Vol. 12, pp 63-86.
Sugi, H. (ed). Springer, Berlin, Heidelberg, New York


Pfitzer G. (1996) Permeabilized smooth muscle. In: The biochemistry of smooth muscle contraction.
Barany, M (ed). Academic press. pp 191-199.


Chalovich, J.M., and Pfitzer, G. (1997). Structure and function of the thin filament proteins of smooth muscle. in: Cellular aspects of smooth muscle function.  Kao, C.Y. and Carsten, M.E. (eds.). Cambridge University press. pp253-287.

 

 

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