This is particularly a nasty error code one gets on most linux platforms if trying to run the VirtualBox binary. The exact error code was like this:

VirtualBox: Error -610 in supR3HardenedMainInitRuntime!
VirtualBox: dlopen("/opt/virtualbox/VBoxRT.so",) failed: <NULL>

VirtualBox: Tip! It may help to reinstall VirtualBox.

Hint It did not help to reinstall VirtualBox. It took some time to find out what has been the root of the trouble. The error makes no sense at all if first reading it.

Hint I found the solution reading following bug report

The problem has been following ownership on a directory where VirtualBox has been installed:

drwxrwxr-x  15 root     wheel 4.0K Jan  7 12:37 opt/

Especially the group membership wheel here root:wheel. The quick fix has been to change the group membership to root:root.

# chown root:root /opt
# ls -lah | grep opt
drwxrwxr-x  15 root     root 4.0K Jun  7 13:37 opt/

Finally this stupid piece of pre compiled crap has been working as supposed. I just wished the error message has been more clear, since it is not possible to find out what to do, without knowing the ins and outs.