UoC

Masters module (MN-B-Gen1)

Molecular Genetics

WS 2017/18

Learning outcomes / Skills

Students who have successfully completed this module will have acquired detailed knowledge of molecular genetics and the cellular repertoire to respond to stress and environmental signals operating at different levels in the cell from gene expression to protein function and signaling.

Students will train to read and comprehend contemporary scientific literature and develop oral presentation skills. Data processing, structuring and presentation will be discussed. Furthermore, they will learn to address and solve biological problems.

Main topics:

Lectures

genetic screens, mutant selection and gene targeting in model organisms

spatial control of protein localization

cellular stress responses such as responses to starvation, temperature, and damaging agents

transcriptional and post-transcriptional regulation, as well as of post-translational regulation by protein modification

selective ubiquitin-mediated protein degradation and degradation of abnormal proteins in yeast and mammals

interactions between the virus and the host cell

Tutorial

formats of scientific literature

searching literature databases for further reading

processing and presenting experimental results in written and oral form

preparing and structuring presentations

addressing and solving scientific problems

Seminar

reading and presenting biological publications

Lectures

at 9 a.m., Seminar room 0.46 (ground floor, Institute for Genetics)

Date	Professor	Lecture	Seminar / Tutorial
04 Dec 2017	Gehring	Introduction and assigning topics for the seminar
05 - 08 Dec 2017	Lammers	ITC Proteins (I) Proteins (II) RhoGNBPs	Methods and their application
11 - 14 Dec 2017	Praefcke	Introduction to buffer design Regulation of Haemostasis Nuclear Organisation and Transport	Data mining
15 - 21 Dec 2017	Gehring/ Schnetz	Eukaryotic mRNA processing Principles of gene expression regulation in eukaryotes Viral strategies Degradation of mRNAs in eukaryotes	Data presentation
08 Jan - 11 Jan 2018	Mörsdorf	Principles of virus infection (I) Principles of virus infection (II) Virus families (I) Virus families (II)	Scientific presentations
12 - 17 Jan 2018	Dohmen	Control and regulation of protein function 1 Control and regulation of protein function 2 Control and regulation of protein function 3 Control and regulation of protein function 4	Solving scientific problems
18 - 23 Jan 2018	Schnetz/ Gehring	Co- and posttranscriptional control in bacteria I Co- and posttranscriptional control in bacteria II Co- and posttranscriptional control in bacteria II	Understanding the Publication Process
(optional 24), 25, 26 Jan 2018	---	Presentations
02 Feb 2018	---	Written examination

Please note: no responsibility is taken for the correctness of the information included in the Seminar / Tutorial files, which were generated by the students of the module

Type of examinations

Exam prerequisites: Regular and active participation

Exams

Written examination (02nd February 2018) of topics presented and discussed during the lectures (70 % of the total module mark).

Oral presentation ([optional 24th], 25th and 26th January 2018) of a current research topic (15 min + discussion, accounts for 30 % of the total module mark).

Faculty / Contact

Jürgen Dohmen

Niels Gehring

Michael Lammers

Dagmar Mörsdorf

Gerrit Praefcke

Karin Schnetz