RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol Cell. 2018 Dec 28. pii: S1097-2765(18)30980-8.
IkB Kinase a Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma. Cancer Res. 2018 Jun 1;78(11):2939-2951. Epub 2018 Mar 27.
The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts.Nat Commun. 2018 Feb 12;9(1):618.
A
brain microvasculature endothelial cell-specific viral vector with the
potential to treat neurovascular and neurological diseases.EMBO Mol Med. 2016 Apr 22. pii: e201506078.
B cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B cell lymphoma in mice. Blood. 2016 Apr 5. pii: blood-2015-11-684183.
NEMO
Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic
Intestinal Inflammation by NF-kB-Dependent and -Independent Functions. Immunity. 2016 Mar 15;44(3):553-67.
Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency. Clin Immunol. 2016 Mar;164:52-6.
A
novel liposomal Clodronate depletes tumor-associated macrophages in
primary and metastatic melanoma: Anti-angiogenic and anti-tumor effects. J Control Release. 2016 Feb 10;223:165-77.
NF-kB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma. J Biol Chem. 2016 Jan;64(1):94-102.
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015 Nov 9;28(5):582-98.
NF-kB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma. J Hepatol. 2015 Sep 5. pii: S0168-8278(15)00613-3.
TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice. Gut. 2015 Mar 11. pii: gutjnl-2014-308323.
Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell. 2014 Dec 8;26(6):880-95.
Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14436-41.
Germinal center B cell maintenance and differentiation are controlled by distinct NF-kB transcription factor subunits. J Exp Med. 2014 Sep 1.[Epub ahead of print]
Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo. J Immunol. 2014 Aug 15;193(4):1539-43. Epub 2014 Jul 11.
Death
receptor-independent FADD signalling triggers hepatitis and
hepatocellular carcinoma in mice with liver parenchymal cell-specific
NEMO knockout.Cell Death Differ. 2014 Jun 27. [Epub ahead of print]
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.J Exp Med. 2014 May 5;211(5):769-79. Epub 2014 Apr 21.
Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis.J Immunol. 2013 Nov 1;191(9):4720-30.
Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria.Am J Physiol Renal Physiol.2012 Nov 15;303(10):F1473-85.
Conditional
Targeting of TRAF6 Reveals Opposing Functions of TLR Signaling in
Endothelial and Myeloid Cells in a Mouse Model of Atherosclerosis.Circulation. 2012 Oct 2;126(14):1739-51.
Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway. Cancer Cell.2012 Jul 10;22(1):91-105.
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol. 2012 May;13(5):481-90.
Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not
chemoattractants and macrophage chemotaxis to C5a is PI3K- and p38
MAPK-independent.J Biol Chem. 2011 Dec 30;286(52):44776-87.
Endothelial and Macrophage-Specific Deficiency of P38α MAPK Does Not Affect the Pathogenesis of Atherosclerosis in ApoE Mice. PLoS One. 2011;6(6):e21055.
Keratinocyte-specific
ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role
in the control of epidermal homeostasis.Cell Death Differ. 2011 May 13.
I{kappa}B
kinase 2 determines oligodendrocyte loss by non-cell-autonomous
activation of NF-{kappa}B in the central nervous system. Brain. 2011 Apr;134(Pt 4):1184-98.
Noncooperative
interactions between transcription factors and clustered DNA binding
sites enable graded transcriptional responses to environmental inputs. Mol Cell. 2010 Feb 12;37(3):418-28.
Development
of immunoglobulin lambda-chain-positive B cells, but not editing of
immunoglobulin kappa-chain, depends on NF-kappaB signals. Nat Immunol. 2009 Jun;10(6):647-54.
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells. Proc Natl Acad Sci U S A.. 2008 Aug 26;105(34):12435-8.
Defective
osteoclastogenesis by IKKbeta -null precursors is a result of
RANKL-induced JNK-dependent apoptosis and impaired differentiation. J Biol Chem. 2008 Jun 19.
Hepatic
NF-kappa B essential modulator deficiency prevents obesity-induced
insulin resistance but synergizes with high-fat feeding in
tumorigenesis.Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1297-302.
Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat Immunol. 2006 Sep;7(9):954-61.
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. J Clin Invest. 2006 Aug;116(8):2094-104.
Elevated
serum levels of calcium-binding S100 proteins A8 and A9 reflect disease
activity and abnormal differentiation of keratinocytes in psoriasis. Br J Dermatol. 2006 Jul;155(1):62-6.
M17,
a gene specific for germinal center (GC) B cells and a prognostic
marker for GC B-cell lymphomas, is dispensable for the GC reaction in
mice. Blood. 2006 Jun 15;107(12):4849-56.
Skin
lesion development in a mouse model of incontinentia pigmenti is
triggered by NEMO deficiency in epidermal keratinocytes and requires
TNF signaling. Hum Mol Genet. 2006 Feb 15;15(4):531-42.
Deletion
of IKK2 in hepatocytes does not sensitize these cells to TNF-induced
apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005 Apr;115(4):849-59.
I
kappa B kinase 2 deficiency in T cells leads to defects in priming, B
cell help, germinal center reactions, and homeostatic expansion. J Immunol. 2004 Aug 1;173(3):1612-9.
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4566-71.
Tumor
necrosis factor and the p55TNF receptor are required for optimal
development of the marginal sinus and for migration of follicular
dendritic cell precursors into splenic follicles. Cell Immunol. 2000 Apr 10;201(1):33-41.
TNF
accelerates the onset but does not alter the incidence and severity of
myelin basic protein-induced experimental autoimmune encephalomyelitis. Eur J Immunol. 1999 Mar;29(3):774-80.
Methotrexate
specifically modulates cytokine production by T cells and macrophages
in murine collagen-induced arthritis (CIA): a mechanism for
methotrexate-mediated immunosuppression. Clin Exp Immunol. 1999 Jan;115(1):42-55.
Oligodendrocyte
apoptosis and primary demyelination induced by local TNF/p55TNF
receptor signaling in the central nervous system of transgenic mice:
models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol. 1998 Sep;153(3):801-13.
In
vivo evidence for a functional role of both tumor necrosis factor (TNF)
receptors and transmembrane TNF in experimental hepatitis. Eur J Immunol. 1997 Nov;27(11):2870-5.
Peyer's
patch organogenesis is intact yet formation of B lymphocyte follicles
is defective in peripheral lymphoid organs of mice deficient for tumor
necrosis factor and its 55-kDa receptor. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6319-23. Erratum in: Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9510.
Immune
and inflammatory responses in TNF alpha-deficient mice: a critical
requirement for TNF alpha in the formation of primary B cell follicles,
follicular dendritic cell networks and germinal centers, and in the
maturation of the humoral immune response. J Exp Med. 1996 Oct 1;184(4):1397-411.
Spontaneous
inflammatory demyelinating disease in transgenic mice showing central
nervous system-specific expression of tumor necrosis factor alpha. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11294-8.
The interplay of IKK, NF-kB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation. Immunol Rev. 2017 May;277(1):113-127. Review.
Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice. J Leukoc Biol. 1996 Apr;59(4):518-25. Review.