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Teaching at the
University of Cologne

Lecture

Advanced
Organic
Chemistry

SoSe & WiSe 
Wed, 11^:00 - 12^:30
Org.Chem.
HS-III

Exams
where&when



Wellcome-
Information
SoSe20

Advanced Organic Chemistry
Reaction Mechanisms & Pericyclic Reactions - Basic Principles & Synthetic Applications

Please recapitulate basic organic reaction mechanisms from previous classes, OC-I, OC-II, eg. SN2, SN1,SR, AdEl, AdR, SElAr, SNuAr, E1, E2, E1cb etc. 

-> Thermodynamics

Gibbs-Energy, Enthalpy, Entropy

Chemical Equilibrium

Benson-Increments

Ring-Strain, Aromaticity
 

-> Kinetics

reaction rate, order, molecularity

Arrhenius-Eq., Ea

Transition-State-Theory, Eyring plots

kinetic vs. thermodynamic control of reactions

Curtin-Hammett principle

Hammond-postulate
 

-> free energy correlations

Bell-Evans-Polanyi

Marcus-theory

LFER, Bronsted, Hammett

Hammett-Eq. sigma, roh, definitions and examples
 

-> kinetic isotop effects & labeling
 

-> tunneling effects

-> acid-base-catalysis 

-> potential energy surfaces

minimum energy path

non-statistical dynamics, molecular dynamics

valley-ridge-inflection-points

computational chemistry

-> transition metal catalysis
 

-> organo-catalysis