Group Leader

Role of Mitofusins and Mitophagy in Life or Death Decisions
Mariana Joaquim, Mafalda Escobar-Henriques (2020), Front. Cell Dev. Biol. 10.3389/fcell.2020.572182

Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion
Mafalda Escobar-Henriques, Vincent Anton (2020), Int J Mol Sci. 10.3390/ijms21186841

Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation
Ramona Schuster, Vincent Anton, Tânia Simões, Selver Altin, Fabian den Brave, Thomas Hermanns, Manuela Hospenthal, David Komander, Gunner Dittmar, R. Jürgen Dohmen, Mafalda Escobar-Henriques (2020), Life Sci Alliance 10.26508/lsa.201900476

Plasticity in salt-bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition
Vincent Anton, Ira Buntenbroich, Ramona Schuster, Felix Babatz, Tânia Simões, Selver Altin, Gaetano Calabrese, Jan Riemer, Astrid Schauss, Mafalda Escobar-Henriques (2019), Life Sci Alliance 10.26508/lsa.201900491

Interplay between the Ubiquitin Proteasome System and Mitochondria for Protein Homeostasis
Mafalda Escobar-Henriques, Selver Altin, Fabian den Brave (2019), Curr Issues Mol Biol. 10.21775/cimb.035.035.

Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases
Mafalda Escobar-Henriques, Mariana Joaquim (2019), Frontiers in Physiology 10.3389/fphys.2019.00517.

Separation and Visualization of Low Abundant Ubiquitylated Forms
Ramona Schuster, Tânia Simões, Fabian den Brave, Mafalda Escobar-Henriques (2018), Bio Protocols 10.21769/BioProtoc.308

Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
Nadav Shai, Eden Yifrach, Carlo W.T. van Roermund, Laetitia Cavellini, Ramona Schuster, Lior Zada, Adam Hughes, Mafalda Escobar-Henriques, Mickael Cohen, Hans Waterham, Ronald Wanders, Maya Schuldiner and Einat Zalckvar (2018), Nature Communications 10.1038/s41467-018-03957-8.

Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion
Tânia Simões, Ramona Schuster, Fabian den Brave, Mafalda Escobar-Henriques (2018), eLife 2018;7:e30015.

Mitofusins: ubiquitylation promotes fusion
M. Escobar-Henriques (2014), Cell Res, 4 387-388.

Dynamic survey of mitochondria by ubiquitin
Mafalda Escobar-Henriques and T. Langer (2014), EMBO Rep, 15(3) 231-243.

Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathway
F. Anton, G. Dittmar, T. Langer and Mafalda Escobar-Henriques (2013), Mol Cell, 49 487-498. Highlighted in Molecular Cell, in Nature Rev. Mol. Cell Biol. and in F1000.

Mechanistic perspective of mitochondrial fusion: tubulation vs. fragmentation
Mafalda Escobar-Henriques and F. Anton, (2013), BBA –Mol. Cell. Research 1833, 162-175.

Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion
F. Anton, J.M. Fres, A. Schauss, B. Pinson, G.-J. Praefcke T. Langer and Mafalda Escobar-Henriques (2011), J. Cell. Sci. 124(7), 1126-1135.

Second PostDoc

Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1
Mafalda Escobar-Henriques, B. Westermann and T. Langer (2006), J. Cell. Biol. 173(5), 645-650.

Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast
M. Dürr, Mafalda Escobar-Henriques, S. Merz, S. Geimer, T. Langer and B. Westermann (2006), Mol. Biol. Cell 17(9), 3745-3755.

Mitochondrial shaping cuts
Mafalda Escobar-Henriques and T. Langer (2006), BBA –Mol. Cell. Research 1763(5-6), 422-429.

First PostDoc

The critical cis-acting element required for IMD2 feedback regulation by GDP is a TATA box located 202 nucleotides upstream of the transcription start site
Mafalda Escobar-Henriques, B. Daignan-Fornier and M. A. Collart (2003),Mol. Cell. Biol. 1763(17), 6267-6278.

Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region
Mafalda Escobar-Henriques, M. A. Collart and B. Daignan-Fornier (2003), Mol. Cell. Biol. 23(17):6279-90.


Proteome analysis and morphological studies reveal multiple effects of the immunosuppressive drug mycophenolic acid specifically resulting from guanylic nucleotide depletion
Mafalda Escobar-Henriques, A. Balguerie, C. Monribot, H. Boucherie and B. Daignan-Fornier (2001), J Biol Chem. 276, 46237-46242.

Transcriptional regulation of the yeast gmp synthesis pathway by its end products
Mafalda Escobar-Henriques and B. Daignan-Fornier (2001), J Biol Chem. 276, 1523-1530.